4-hydroxybenzoic acid (CID 135) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(27)
 
 
Inactive(33)
 
 
Inconclusive(2)
 
 
Unspecified(84)
 
 
Top Targets:
alpha CA I II..(10)
 
 
 
alpha CA XII..(4)
 
 
GT1 Gtf like(4)
 
 
alpha CA(4)
 
 
 
PTKc EGFR(3)
 
 
 
BioAssay Types:
Literature(91)
 
 
 
 
 
Confirmatory(21)
 
 
Screening(3)
 
 
BioActivity Types:
Ki(29)
 
 
 
IC50(22)
 
 
 
Potency(21)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 146    Data Row: 146   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176360]
IC50 0.2Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhagic lesion formation compound incubated with venom for 10 mins and administered subcutaneously measured after 24 hrs [AID631927, Type: Literature]
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2
[SID103176360]
Ki 0.87Inhibition of human CA2 by stopped-flow CO2 hydration assay [AID462271, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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3
[SID103176360]
Ki 0.92Inhibition of human CA1 by stopped-flow CO2 hydration assay [AID462270, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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4
[SID103176360]
Ki 3.67Inhibition of human CA5A by stopped-flow CO2 hydration assay [AID462274, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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5
[SID103176360]
Ki 3.73Inhibition of human CA9 by stopped-flow CO2 hydration assay [AID462278, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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6
[SID103176360]
Ki 4.08Inhibition of human CA7 by stopped-flow CO2 hydration assay [AID462277, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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7
[SID103176360]
Ki 4.8Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay [AID342484, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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8
[SID103176360]
Ki 5.7Inhibition of human CA6 by stopped-flow CO2 hydration assay [AID462276, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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9
[SID103176360]
Ki 6.16Inhibition of human CA14 by stopped-flow CO2 hydration assay [AID462281, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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10
[SID103176360]
Ki 6.27Inhibition of human CA12 by stopped-flow CO2 hydration assay [AID462279, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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11
[SID103176360]
Ki 6.61Inhibition of human CA3 by stopped-flow CO2 hydration assay [AID462272, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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12
[SID103176360]
Ki 7.13Inhibition of human CA5B by stopped-flow CO2 hydration assay [AID462275, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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13
[SID103176360]
Ki 7.78Inhibition of human CA4 by stopped-flow CO2 hydration assay [AID462273, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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14
[SID103176360]
Ki 7.79Inhibition of mouse CA13 by stopped-flow CO2 hydration assay [AID462280, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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15
[SID103176360]
Ki 8.46Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay [AID607497, Type: Literature]Carbonic anhydrase [gi:123910379]
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16
[SID103176360]
Ki 9.2Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay [AID342479, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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17
[SID103176360]
Ki 9.32Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay [AID331293, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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18
[SID103176360]
Ki 9.8Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay [AID331291, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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19
[SID103176360]
Ki 9.8Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay [AID342475, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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20
[SID103176360]
Ki 10.5Inhibition of human carbonic anhydrase 5B by stopped-flow CO2 hydration assay [AID342480, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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21
[SID103176360]
Ki 10.6Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay [AID342476, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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22
[SID103176360]
Ki 10.6Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay [AID331292, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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23
[SID103176360]
Ki 11.4Inhibition of human carbonic anhydrase 6 by stopped-flow CO2 hydration assay [AID342481, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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24
[SID103176360]
IC50 33.3Cytotoxicity against mouse Colon 26-L5 cells after 72 hrs by MTT assay [AID470665, Type: Literature]
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25
[SID103176360]
Ki 34.3Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay [AID342485, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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26
[SID103176360]
IC50 36.2Cytotoxicity against human HeLa cells after 72 hrs by MTT assay [AID470664, Type: Literature]
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27
[SID103176360]
 Competitive inhibition of mushroom tyrosinase assessed as L-3,4-dihydroxyphenylalanine oxidation [AID398376, Type: other]Polyphenol oxidase 2 [gi:6686057]
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28
[SID103176360]
IC50 63.3Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay [AID470666, Type: Literature]
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29
[SID103176360]
IC50 71Cytotoxicity against human OE21 cells after 72 hrs by MTT assay [AID607594, Type: Literature]
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30
[SID103176360]
Ki 86Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay [AID342486, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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31
[SID103176360]
IC50 94Cytotoxicity against human LoVo cells after 72 hrs by MTT assay [AID607598, Type: Literature]
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32
[SID103176360]
IC50 100Cytotoxicity against human U373 cells after 72 hrs by MTT assay [AID607593, Type: Literature]
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33
[SID103176360]
IC50 100Cytotoxicity against human A549 cells after 72 hrs by MTT assay [AID607595, Type: Literature]
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34
[SID103176360]
IC50 100Cytotoxicity against human PC3 cells after 72 hrs by MTT assay [AID607596, Type: Literature]
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35
[SID103176360]
IC50 100Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay [AID607597, Type: Literature]
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36
[SID103176360]
IC50 100Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay [AID470662, Type: Literature]
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37
[SID103176360]
IC50 100Cytotoxicity against human A549 cells after 72 hrs by MTT assay [AID470663, Type: Literature]
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38
[SID103176360]
Ki 118Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay [AID342483, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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39
[SID103176360]
IC50 200Antitumor activity against KB cells by MTT assay [AID290547, Type: Literature]
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40
[SID103176360]
IC50 200Antitumor activity against KBv200 cells by MTT assay [AID290548, Type: Literature]
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41
[SID103176360]
MIC 362Antitubercular activity against Mycobacterium tuberculosis 90-221387 [AID278000, Type: Literature]
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42
[SID103176360]
Ki 696Inhibition of human carbonic anhydrase 3 by stopped-flow CO2 hydration assay [AID342477, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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43
[SID103176360]
Ki 716Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay [AID342482, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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44
[SID103176360]
Ki 809Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay [AID342478, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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45
[SID103176360]
IC50 1000Inhibitory activity against SSADH [AID260087, Type: Literature]Succinate-semialdehyde dehydrogenase, mitochondrial [gi:7531278]
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46
[SID103176360]
IC50 1000Inhibitory activity against GABAT [AID260086, Type: Literature]4-aminobutyrate aminotransferase, mitochondrial [gi:48429239]
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47
[SID103176360]
IC50 1737.8pI50 was determined [AID29132, Type: Literature]
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48
[SID103176360]
IC50 1737.8Inhibition of purified human kidney thiopurine methyltransferase (TPMT) [AID213093, Type: Literature]
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49
[SID103176360]
ID50 1900Inhibition of mushroom tyrosinase assessed as L-3,4-dihydroxyphenylalanine oxidation [AID398374, Type: other]Polyphenol oxidase 2 [gi:6686057]
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50
[SID103176360]
IC50 16250Inhibition of pieris rapae Phenoloxidase [AID293934, Type: Literature]
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