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N-[1-benzyl-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]acetamide (CID 1348667) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(692)
 
 
Inconclusive(22)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
p450(8)
 
 
 
BioAssay Types:
Screening(495)
 
 
 
 
 
Confirmatory(210)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(151)
 
 
 
 
 
IC50(45)
 
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 662    Data Row: 728   Total Pages: 15   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17415854]
Potency 15.8489qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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2
[SID17415854]
Potency 50.1187Confirmation of Inhibitors and Activators of Purified Human alpha-Galactosidase [AID2109, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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3
[SID17415854]
Potency 50.1187Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase [AID2115, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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4
[SID17415854]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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5
[SID17415854]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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6
[SID17415854]
IC50 uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. [AID1434, Type: confirmatory]runt-related transcription factor 1 isoform AML1c [Homo sapiens] [gi:19923198]
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7
[SID17415854]
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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8
[SID17415854]
Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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9
[SID17415854]
IC50 uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. [AID1434, Type: confirmatory]core-binding factor subunit beta isoform 1 [Homo sapiens] [gi:13124881]
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10
[SID17415854]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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11
[SID17415854]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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12
[SID17415854]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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13
[SID17415854]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID17415854]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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15
[SID17415854]
Potency 10qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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16
[SID17415854]
Potency 15.8489qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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17
[SID17415854]
Potency 16.5113Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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18
[SID17415854]
Potency 25.1189qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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19
[SID17415854]
Potency qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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20
[SID17415854]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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21
[SID17415854]
HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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22
[SID17415854]
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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23
[SID17415854]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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24
[SID17415854]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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25
[SID17415854]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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26
[SID17415854]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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27
[SID17415854]
uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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28
[SID17415854]
uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463195, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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29
[SID17415854]
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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30
[SID17415854]
Potency qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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31
[SID17415854]
Potency qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1722, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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32
[SID17415854]
Potency qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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33
[SID17415854]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID492953, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
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34
[SID17415854]
IC50 Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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35
[SID17415854]
LYP Inhibitors-an Autoimmunity Target - Primary screen [AID640, Type: screening]tyrosine-protein phosphatase non-receptor type 22 isoform 2 [Homo sapiens] [gi:301171662]
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36
[SID17415854]
LYP Activators-an Autoimmunity Target - Primary screen [AID697, Type: screening]tyrosine-protein phosphatase non-receptor type 22 isoform 2 [Homo sapiens] [gi:301171662]
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37
[SID17415854]
uHTS for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID782, Type: screening]eukaryotic translation initiation factor 4 gamma 1 isoform 4 [Homo sapiens] [gi:302699239]
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38
[SID17415854]
C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_Activity [AID504423, Type: screening]LANA [Human herpesvirus 8] [gi:312275222]
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39
[SID17415854]
Potency qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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40
[SID17415854]
Factor XIIa 1536 HTS [AID800, Type: screening]Coagulation factor XII [gi:317373446]
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41
[SID17415854]
Potency qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720707, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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42
[SID17415854]
Potency qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720709, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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43
[SID17415854]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4). [AID720543, Type: screening]abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] [gi:326937491]
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44
[SID17415854]
Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]anoctamin-1 isoform 1 [Mus musculus] [gi:334278898]
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45
[SID17415854]
Primary cell-based high-throughput screening for identification of compounds that activate/potentiate calcium-activated chloride channels (TMEM16A) [AID623877, Type: screening]anoctamin-1 isoform 1 [Mus musculus] [gi:334278898]
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46
[SID17415854]
Potency qHTS for Inhibitors of KCHN2 3.1: Wildtype qHTS [AID720551, Type: confirmatory]potassium voltage-gated channel subfamily H member 2 isoform a [Homo sapiens] [gi:342840031]
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47
[SID17415854]
Potency qHTS for Inhibitors of KCHN2 3.1: Mutant qHTS [AID720553, Type: confirmatory]potassium voltage-gated channel subfamily H member 2 isoform a [Homo sapiens] [gi:342840031]
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48
[SID17415854]
Potency qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction [AID624246, Type: confirmatory]transcriptional regulator ERG isoform 3 [Homo sapiens] [gi:343478176]
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49
[SID17415854]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624377, Type: screening]arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2 [Homo sapiens] [gi:351542238]
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50
[SID17415854]
Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-01_Inhibitor_SinglePoint_HTS_Activity [AID602481, Type: screening]bioA [Mycobacterium tuberculosis UT205] [gi:378544807]
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