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febuxostat (CID 134018) - Compound BioActivity Data
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BioActivity Outcomes:
Active(17)
 
 
Inactive(65)
 
 
Inconclusive(30)
 
 
Unspecified(6)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
Ald Xan dh C2(7)
 
 
 
NR LBD ER(7)
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD GR(4)
 
 
 
BioAssay Types:
Confirmatory(76)
 
 
 
 
Summary(24)
 
 
 
 
Literature(14)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(94)
 
 
 
 
IC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 118    Data Row: 118   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103765728]
IC50 0.00126Inhibition of C-terminally FLAG-tagged human xanthine oxidase (amino acid 1 to 1333) expressed in baculovirus system after 15 mins by spectrophotometry [AID1075893, Type: Literature]Xanthine dehydrogenase/oxidase [gi:2506326]
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2
[SID103765728]
IC50 0.003Inhibition of bovine xanthine oxidase by spectrophotometry [AID486916, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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3
[SID103765728]
IC50 0.00398Inhibition of rat xanthine oxidase [AID1075895, Type: Literature]Xanthine dehydrogenase/oxidase [gi:1351440]
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4
[SID103765728]
IC50 0.02Inhibition of bovine xanthine oxidase-mediated uric acid production after 30 mins by spectrophotometric analysis [AID728035, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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5
[SID103765728]
IC50 0.025Inhibition of bovine milk xanthine oxidase using xanthine as substrate assessed as decrease in uric acid formation preincubated for 5 mins [AID1064493, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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6
[SID144206555]
AhR Potency (uM) 0.0266032qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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7
[SID144206555]
Potency-Replicate_1 0.0298qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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8
[SID103765728]
IC50 0.03Inhibition of xanthine oxidase using xanthine as substrate at 30 mins by spectrophotometric analysis [AID717724, Type: Literature]
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9
[SID124893781]
Potency 0.0361Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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10
[SID144206555]
Potency-Replicate_1 0.1496qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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11
[SID144206555]
ATAD5 Potency (uM) 0.167855qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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12
[SID144206555]
Potency-Replicate_1 1.1883qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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13
[SID144206555]
Potency 7.9433qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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14
[SID144206555]
Potency-Replicate_1 13.3332qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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15
[SID144206555]
TR Potency (uM) 16.7855qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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16
[SID103765728]
Plasma concentration in potassium oxonate-induced hyperuricemic Sprague-Dawley rat model at 10 mg/kg, po measured after 2 hrs [AID1075875, Type: Literature]
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17
[SID103765728]
Xanthine dehydrogenase inhibitor [AID742846, Type: other]Xanthine dehydrogenase/oxidase [gi:2506326]
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18
[SID103765728]
Ratio of IC50 for rat xanthine oxidase to IC50 for C-terminally FLAG-tagged human xanthine oxidase (amino acid 1 to 1333) expressed in baculovirus system [AID1075873, Type: Literature]
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19
[SID103765728]
Antihyperuricemic activity in potassium oxonate-induced hyperuricemic Sprague-Dawley rat model assessed as decrease of uric acid level in serum at 10 mg/kg, po measured after 1 hr relative to vehicle-treated control [AID1075877, Type: Literature]
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20
[SID103765728]
Antihyperuricemic activity in potassium oxonate-induced hyperuricemic Sprague-Dawley rat model assessed as decrease of uric acid level in serum at 10 mg/kg, po measured after 2 hrs relative to vehicle-treated control [AID1075878, Type: Literature]
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