CHEMBL142 (CID 13307260) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(201)
 
 
Inactive(4)
 
 
Inconclusive(1)
 
 
Unspecified(193)
 
 
Top Targets:
7TM GPCR Srx(48)
 
 
 
 
GT1 Gtf like(7)
 
 
7tm 2(2)
 
 
7TM GPCR Srv(1)
 
 
NOS oxygenase..(1)
 
 
BioAssay Types:
Literature(381)
 
 
 
 
 
BioActivity Types:
Ki(109)
 
 
 
IC50(30)
 
 
EC50(4)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 399    Data Row: 399   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103197153]
Ki 2e-05Ratio of mu/delta-opioid receptors Binding affinity [AID228132, Type: Literature]Mu-type opioid receptor [gi:2851402]
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2
[SID103197153]
Ki 2e-05Ratio of mu/delta-opioid receptors Binding affinity [AID228132, Type: Literature]Mu-type opioid receptor [gi:2851402]
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3
[SID103197153]
Ki 2e-05Ratio of mu/delta-opioid receptors Binding affinity [AID228132, Type: Literature]Mu-type opioid receptor [gi:2851402]
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4
[SID103197153]
Ki 2e-05Ratio of mu/delta-opioid receptors Binding affinity [AID228132, Type: Literature]Mu-type opioid receptor [gi:2851402]
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5
[SID103197153]
Ki 4e-05Ratio of kappa/delta-opioid receptors Binding affinity [AID228131, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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6
[SID103197153]
Ki 4e-05Ratio of kappa/delta-opioid receptors Binding affinity [AID228131, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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7
[SID103197153]
Ki 4e-05Ratio of kappa/delta-opioid receptors Binding affinity [AID228131, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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8
[SID103197153]
Ki 4e-05Ratio of kappa/delta-opioid receptors Binding affinity [AID228131, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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9
[SID103197153]
Ki 7e-05Displacement of [125I]-IBOxyA from MOR-1 expressed in CHO cells [AID603171, Type: Literature]
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10
[SID103197153]
Ki 0.00017Binding affinity towards Opioid receptor mu 1 of guinea pig brain membranes using radioligand 0.25 nM [3H]DAMGO [AID148030, Type: Literature]
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11
[SID103197153]
Ki 0.00017Binding affinity was determined towards opioid receptor mu1 using [3H]DAMGO as radioligand [AID152226, Type: Literature]
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12
[SID103197153]
Ki 0.0002Displacement of [3H]DAMGO from human recombinant Opioid receptor mu 1 on CHO cell membranes. [AID150841, Type: Literature]
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13
[SID103197153]
IC50 0.0002Inhibitory concentration was determined against Opioid receptor mu 1 using [3H]- DAMGO radioligand [AID149863, Type: Literature]
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14
[SID103197153]
Ki 0.0002Inhibition of [3H]DAMGO binding to human Mu opioid receptor expressed in CHO cells [AID239328, Type: Literature]Mu-type opioid receptor [gi:2851402]
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15
[SID103197153]
Ki 0.0002Inhibition of [3H]DAMGO binding to human Mu opioid receptor expressed in CHO cells [AID239328, Type: Literature]Mu-type opioid receptor [gi:2851402]
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16
[SID103197153]
Ki 0.0002Inhibition of [3H]DAMGO binding to human Mu opioid receptor expressed in CHO cells [AID239328, Type: Literature]Mu-type opioid receptor [gi:2851402]
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17
[SID103197153]
Ki 0.0002Inhibition of [3H]DAMGO binding to human Mu opioid receptor expressed in CHO cells [AID239328, Type: Literature]Mu-type opioid receptor [gi:2851402]
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18
[SID103197153]
IC50 0.00023Tested for the binding affinity against the Mu opioid receptor in guinea pig brain using [3H]-DAMGO [AID141490, Type: Literature]
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19
[SID103197153]
Ki 0.00026Displacement of [3H]naloxone from monocloned mu opioid receptor expressed in CHO cells [AID347309, Type: Literature]
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20
[SID103197153]
Ki 0.00026Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells [AID415721, Type: Literature]
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21
[SID103197153]
Ki 0.0003Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells by visible spectrophotometry [AID450016, Type: Literature]
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22
[SID103197153]
Ki 0.00031Binding affinity towards guinea pig Opioid receptor kappa 1 using radioligand [3H]U-69593 [AID149262, Type: Literature]
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23
[SID103197153]
Ki 0.00031Binding affinity was determined towards opioid receptor kappa 1 using [3H]U-69593 as radioligand [AID149266, Type: Literature]
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24
[SID103197153]
Ki 0.0004Displacement of [3H]U-69593 from human recombinant Opioid receptor kappa 1 on CHO cell membranes. [AID147987, Type: Literature]
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25
[SID103197153]
Ki 0.0004Inhibition of [3H]U-69593 binding to human kappa opioid receptor expressed in CHO cells [AID239386, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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26
[SID103197153]
Ki 0.0004Inhibition of [3H]U-69593 binding to human kappa opioid receptor expressed in CHO cells [AID239386, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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27
[SID103197153]
Ki 0.0004Inhibition of [3H]U-69593 binding to human kappa opioid receptor expressed in CHO cells [AID239386, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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28
[SID103197153]
Ki 0.0004Inhibition of [3H]U-69593 binding to human kappa opioid receptor expressed in CHO cells [AID239386, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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29
[SID103197153]
IC50 0.0005Inhibitory concentration against Opioid receptor kappa 1 using [3H]- U-69,593 radioligand [AID148688, Type: Literature]
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30
[SID103197153]
IC50 0.0005Inhibition of [3H]naloxone binding to opioid receptor in presence of NaCl [AID150392, Type: Literature]
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31
[SID103197153]
IC50 0.00053Tested for the binding affinity against the Kappa opioid receptor in guinea pig brain using [3H]U-69593 [AID148692, Type: Literature]
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32
[SID103197153]
Ki 0.00055Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family) [AID150398, Type: Literature]Delta-type opioid receptor [gi:464311]
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33
[SID103197153]
Ki 0.00056Binding affinity against Opioid receptor mu 1 using [3H]naloxone as radioligand. [AID152204, Type: Literature]
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34
[SID103197153]
Ki 0.00056Binding affinity was determined against Mu opioid receptor using [3H]naltrexone as radioligand [AID141506, Type: Literature]
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35
[SID103197153]
Ki 0.00056Tested for binding affinity towards mu receptor in presence of [3H]NAL radioligand [AID141762, Type: Literature]
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36
[SID103197153]
Ki 0.00056Binding affinity towards mu-opioid receptor by the displacement of [3H]Nal in rat brain homogenates [AID224587, Type: Literature]
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37
[SID103197153]
Ki 0.00056Binding affinity towards mu opioid receptor by displacement of [3H]NAL from rat brain homogenates [AID224718, Type: Literature]
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38
[SID103197153]
EC50 0.00059Effective concentration agonistic activity towards Opioid receptor mu 1 [AID148339, Type: Literature]Mu-type opioid receptor [gi:2851402]
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39
[SID103197153]
EC50 0.00059Effective concentration agonistic activity towards Opioid receptor mu 1 [AID148339, Type: Literature]Mu-type opioid receptor [gi:2851402]
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40
[SID103197153]
EC50 0.00059Effective concentration agonistic activity towards Opioid receptor mu 1 [AID148339, Type: Literature]Mu-type opioid receptor [gi:2851402]
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41
[SID103197153]
EC50 0.00059Effective concentration agonistic activity towards Opioid receptor mu 1 [AID148339, Type: Literature]Mu-type opioid receptor [gi:2851402]
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42
[SID103197153]
Ki 0.0006Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain homogenate [AID273136, Type: Literature]
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43
[SID103197153]
IC50 0.00062Inhibition of [3H]naloxone binding to opioid receptor in presence of NaCl [AID149041, Type: Literature]
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44
[SID103197153]
IC50 0.00073inhibition of 1.0 nM [3H]- DAGO binding to guinea pig brain membrane opioid receptor mu [AID148992, Type: Literature]
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45
[SID103197153]
IC50 0.00073Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain membrane [AID148993, Type: Literature]
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46
[SID103197153]
Ki 0.00075Binding affinity against Opioid receptor mu 1 in Guinea pig brain membranes using [3H]DAMGO [AID148025, Type: Literature]
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47
[SID103197153]
Ki 0.0008Binding affinity was determined in a crude membrane preparation from guinea pig brain by displacement of [3H]DAMGO from Opioid receptor mu 1 [AID148038, Type: Literature]
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48
[SID103197153]
Ki 0.0008Binding affinity was measured by the displacement of [3H]- DAMGO in guinea pig brain membrane of Opioid receptor mu 1 [AID148040, Type: Literature]
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49
[SID103197153]
Ki 0.0008Compound was evaluated for binding affinity at Opioid receptor mu 1 in guinea pig brain membranes [AID148041, Type: Literature]
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50
[SID103197153]
Ki 0.0008Binding affinity was measured by the displacement of [3H]- DAMGO in guinea pig brain membrane of opioid receptor mu [AID149011, Type: Literature]
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