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N,N-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide (CID 132496) - Compound BioActivity Data
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BioActivity Outcomes:
Active(48)
 
 
Inactive(683)
 
 
Inconclusive(72)
 
 
Unspecified(27)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
 
 
7TM GPCR Srsx(16)
 
 
p450(12)
 
 
 
 
ANK(11)
 
 
 
PLDc mTdp1 2(9)
 
 
 
 
BioAssay Types:
Confirmatory(421)
 
 
 
 
 
Screening(340)
 
 
 
 
Literature(49)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(363)
 
 
 
 
 
IC50(37)
 
 
 
 
Ki(3)
 
 
Kd(1)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 652    Data Row: 830   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103259311]
EC50 0.003Concentration required to stimulate pregnenolone formation in the mitochondria of C6-2B glioma cells . [AID44631, Type: Literature]
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2
[SID103259311]
Kd 0.004Binding affinity to human PBR [AID408746, Type: Literature]Translocator protein [gi:313104268]
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3
[SID103259311]
Ki 0.0044Binding affinity was determined as the ability to displace [3H]4''CD from the (mDRC) mitochondrial DBI receptor complex using primary cultures of glial cells [AID126589, Type: Literature]
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4
[SID103259311]
Ki 0.0044Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells [AID221360, Type: Literature]Translocator protein [gi:130253]
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5
[SID103259311]
Ki 0.005Displacement of [3H]PK11195 from TSPO in rat cortex [AID368146, Type: Literature]Translocator protein [gi:130253]
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6
[SID103259311]
IC50 0.01Displacement of [3H]PK11195 binding from peripheral benzodiazepine receptor in C6 rat glioma cell line [AID42313, Type: Literature]Translocator protein [gi:130253]
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7
[SID103259311]
IC50 0.01Displacement of [3H]PK11195 binding from peripheral benzodiazepine receptor in MA-10 mouse tumor Leydig cells [AID42148, Type: Literature]Translocator protein [gi:1730586]
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8
[SID11113625]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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9
[SID103259311]
IC50 3.16228Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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10
[SID50104521]
Potency 3.5481qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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11
[SID85231015]
Potency 3.6964Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
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12
[SID103259311]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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13
[SID50104521]
Potency 3.9811qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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14
[SID11113625]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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15
[SID103259311]
IC50 5.01187Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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16
[SID50104521]
Potency 5.0119qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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17
[SID50104521]
Potency 5.0119qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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18
[SID85231015]
Potency 5.2213Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID488752, Type: confirmatory]
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19
[SID56463201]
Potency 5.8584Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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20
[SID103259311]
IC50 6.30957Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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21
[SID103259311]
IC50 6.30957Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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22
[SID50104521]
Potency 7.0795qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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23
[SID90341391]
Potency 9.1962qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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24
[SID50104522]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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25
[SID90341391]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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26
[SID85231015]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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27
[SID11111106]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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28
[SID11113625]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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29
[SID26751826]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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30
[SID124879955]
Potency 9.4411qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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31
[SID50104521]
Potency 10qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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32
[SID103259311]
IC50 10Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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33
[SID103259311]
IC50 10Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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34
[SID50104521]
Potency 10qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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35
[SID124879955]
Potency 10.5931qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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36
[SID50104521]
Potency 12.5893qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10 [AID1877, Type: confirmatory]
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37
[SID56463201]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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38
[SID123060012]
Potency 26.7737Followup screen of LOPAC molecules that induce DNA re-replication in SW480 adenocarcinoma cells [AID504806, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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39
[SID123060012]
Potency 26.7737Followup screen of LOPAC molecules that induce DNA re-replication in SW480 adenocarcinoma cells [AID504806, Type: confirmatory] [geneid:51053]
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40
[SID50104521]
Potency 31.6228qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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41
[SID11113625]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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42
[SID11111106]
Potency 31.6228qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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43
[SID11111106]
Potency 31.6228qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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44
[SID11113625]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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45
[SID56463201]
Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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46
[SID50104521]
qHTS for Inhibitors of Plasmodium falciparum proliferation: Summary [AID1828, Type: summary]
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47
[SID11113625]
Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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48
[SID11113625]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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49
[SID103259311]
IC50 1Inhibitory activity, measured by displacement [3H]CP-55940 from cannabinoid receptor (CB1) in rat brain [AID49145, Type: Literature]
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50
[SID103259311]
IC50 1Inhibitory activity at GABA B receptor, measured by the ability to displace [3H]baclofen from GABA B receptor in rat brain [AID71403, Type: Literature]
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