N,N-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide (CID 132496) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(45)
 
 
Inactive(589)
 
 
Inconclusive(64)
 
 
Unspecified(27)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
p450(13)
 
 
 
 
 
Tubulin-bindi..(8)
 
 
 
PLN02808(8)
 
 
Geminin(8)
 
 
 
 
BioAssay Types:
Confirmatory(368)
 
 
 
 
 
Screening(290)
 
 
 
 
Literature(47)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(313)
 
 
 
 
 
IC50(37)
 
 
 
 
Ki(3)
 
 
EC50(1)
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 608    Data Row: 725   Total Pages: 15   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103259311]
EC50 0.003Concentration required to stimulate pregnenolone formation in the mitochondria of C6-2B glioma cells . [AID44631, Type: Literature]
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2
[SID103259311]
Kd 0.004Binding affinity to human PBR [AID408746, Type: Literature]Translocator protein [gi:313104268]
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3
[SID103259311]
Ki 0.0044Binding affinity was determined as the ability to displace [3H]4''CD from the (mDRC) mitochondrial DBI receptor complex using primary cultures of glial cells [AID126589, Type: Literature]
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4
[SID103259311]
Ki 0.0044Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells [AID221360, Type: Literature]Translocator protein [gi:130253]
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5
[SID103259311]
Ki 0.0044Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells [AID221360, Type: Literature]Translocator protein [gi:130253]
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6
[SID103259311]
Ki 0.005Displacement of [3H]PK11195 from TSPO in rat cortex [AID368146, Type: Literature]Translocator protein [gi:130253]
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7
[SID103259311]
Ki 0.005Displacement of [3H]PK11195 from TSPO in rat cortex [AID368146, Type: Literature]Translocator protein [gi:130253]
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8
[SID103259311]
IC50 0.01Displacement of [3H]PK11195 binding from peripheral benzodiazepine receptor in C6 rat glioma cell line [AID42313, Type: Literature]Translocator protein [gi:130253]
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9
[SID103259311]
IC50 0.01Displacement of [3H]PK11195 binding from peripheral benzodiazepine receptor in C6 rat glioma cell line [AID42313, Type: Literature]Translocator protein [gi:130253]
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10
[SID103259311]
IC50 0.01Displacement of [3H]PK11195 binding from peripheral benzodiazepine receptor in MA-10 mouse tumor Leydig cells [AID42148, Type: Literature]Translocator protein [gi:1730586]
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11
[SID11113625]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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12
[SID11113625]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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13
[SID11113625]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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14
[SID103259311]
IC50 3.16228Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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15
[SID50104521]
Potency 3.5481qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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16
[SID85231015]
Potency 3.6964Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
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17
[SID103259311]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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18
[SID50104521]
Potency 3.9811qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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19
[SID11113625]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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20
[SID11113625]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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21
[SID103259311]
IC50 5.01187Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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22
[SID50104521]
Potency 5.0119qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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23
[SID50104521]
Potency 5.0119qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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24
[SID85231015]
Potency 5.2213Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID488752, Type: confirmatory]
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25
[SID56463201]
Potency 5.8584Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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26
[SID103259311]
IC50 6.30957Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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27
[SID103259311]
IC50 6.30957Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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28
[SID50104521]
Potency 7.0795qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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29
[SID26751826]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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30
[SID90341391]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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31
[SID90341391]
Potency 9.1962qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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32
[SID85231015]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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33
[SID11111106]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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34
[SID11113625]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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35
[SID50104522]
Potency 9.1962qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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36
[SID124879955]
Potency 9.4411qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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37
[SID124879955]
Potency 9.4411qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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38
[SID124879955]
Potency 9.4411qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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39
[SID50104521]
Potency 10qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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40
[SID103259311]
IC50 10Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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41
[SID103259311]
IC50 10Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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42
[SID50104521]
Potency 10qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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43
[SID124879955]
Potency 10.5931qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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44
[SID124879955]
Potency 10.5931qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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45
[SID124879955]
Potency 10.5931qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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46
[SID50104521]
Potency 12.5893qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10 [AID1877, Type: confirmatory]
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47
[SID56463201]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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48
[SID56463201]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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49
[SID56463201]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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50
[SID123060012]
Potency 26.7737Followup screen of LOPAC molecules that induce DNA re-replication in SW480 adenocarcinoma cells [AID504806, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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