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salvinorin A (CID 128563) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(61)
 
 
Inactive(4)
 
 
Inconclusive(11)
 
 
Unspecified(73)
 
 
Top Targets:
7TM GPCR Srx(74)
 
 
 
 
 
7TM GPCR Srsx(2)
 
 
BioAssay Types:
Literature(149)
 
 
 
 
 
BioActivity Types:
Ki(55)
 
 
 
 
EC50(22)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 146    Data Row: 149   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103457931]
EC50 0.0002Agonist activity at kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay [AID552823, Type: Literature]
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2
[SID103457931]
Ki 0.00075Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells [AID552820, Type: Literature]
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3
[SID103457931]
Ki 0.00075Displacement of [3H]U-69593 from rat cloned KOR [AID290338, Type: Literature]Kappa-type opioid receptor [gi:464313]
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4
[SID103457931]
Ki 0.0008Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells by visible spectrophotometry [AID450018, Type: Literature]
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5
[SID103457931]
EC50 0.00081Agonist activity at human kappa opioid receptor-Galpha-16 fusion protein expressed in CHO cells by calcium flux assay [AID378998, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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6
[SID103457931]
EC50 0.00124Agonist activity at human kappa opioid receptor assessed as inhibition of Galpha-16-induced calcium flux [AID302207, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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7
[SID103457931]
Ki 0.0013Inhibition of [3H]diprenorphine binding to human KOR expressed in CHO cells [AID270608, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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8
[SID103457931]
Ki 0.0013Displacement of [3H]diprenorphine binding from human kappa opioid receptor expressed in CHO cells [AID276331, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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9
[SID103457931]
EC50 0.0018Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID321653, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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10
[SID103457931]
Ki 0.0019Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cells [AID329901, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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11
[SID103457931]
Ki 0.0019Inhibition of [125I]- IOXY binding to human Opioid receptor kappa1 [AID238722, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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12
[SID103457931]
Ki 0.0019Binding affinity to kappa opioid receptor [AID488649, Type: Literature]
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13
[SID103457931]
Ki 0.0019Displacement of [125]OXY from kappa opioid receptor [AID377277, Type: Literature]
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14
[SID103457931]
EC50 0.0021Agonist activity at human KOPR expressed in CHO cells assessed as enhancenment of [35S]GTPgammaS binding [AID369068, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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15
[SID103457931]
Ki 0.0024Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cells [AID321650, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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16
[SID103457931]
Ki 0.0025Displacement of [3H]diprenorphine from human KOPR expressed in CHO cells [AID369067, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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17
[SID103457931]
EC50 0.00282Activity at human kappa opioid receptor expressed in HEK293 cells as intracellular calcium mobilization [AID290339, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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18
[SID103457931]
Ki 0.0029Displacement of [3H]diprenorphine from rat kappa opioid receptor I294A mutant expressed in HEK293 cells [AID317019, Type: Literature]
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19
[SID103457931]
Ki 0.003Displacement of [3H]diprenorphine from human KOPR expressed in CHO cells [AID640425, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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20
[SID103457931]
Ki 0.004Inhibition of [3H]U-69593 binding to rat opioid receptor kappa 1 expressed in HEK 293 cells [AID239396, Type: Literature]
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21
[SID103457931]
EC50 0.0045Enhancement of [35S]GTP-gamma-S binding to human KOR expressed in CHO cells [AID270609, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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22
[SID103457931]
EC50 0.0045Binding potency at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID276332, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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23
[SID103457931]
EC50 0.00611Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as caclium mobilization after 1 hrs by fluorescence analysis [AID659121, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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24
[SID103457931]
Ki 0.0068Displacement of [3H]diprenorphine from rat kappa opioid receptor Y66F mutant expressed in HEK293 cells [AID317016, Type: Literature]
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25
[SID103457931]
EC50 0.0069Agonist activity at human KOPR expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by liquid scintillation counting [AID640424, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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26
[SID103457931]
Ki 0.0074Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation counting [AID659115, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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27
[SID103457931]
Ki 0.0074Displacement of [3H]U69593 from kappa opioid receptor [AID595420, Type: Literature]
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28
[SID103457931]
EC50 0.0075Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as increase of [35S]GTPgammaS binding [AID516775, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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29
[SID103457931]
Ki 0.0095Displacement of [3H]diprenorphine from rat kappa opioid receptor Y139F mutant expressed in HEK293 cells [AID317025, Type: Literature]
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30
[SID103457931]
Ki 0.016Displacement of [3H]diprenorphine from rat kappa opioid receptor Y312F mutant expressed in HEK293 cells [AID317028, Type: Literature]
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31
[SID103457931]
Ki 0.0175Displacement of [3H]diprenorphine from rat kappa opioid receptor D138A mutant expressed in HEK293 cells [AID317024, Type: Literature]
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32
[SID103457931]
Ki 0.0175Displacement of [3H]diprenorphine from rat kappa opioid receptor expressed in HEK293 cells [AID317013, Type: Literature]Kappa-type opioid receptor [gi:464313]
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33
[SID103457931]
Ki 0.0177Displacement of [3H]diprenorphine from rat kappa opioid receptor Y119F mutant expressed in HEK293 cells [AID317023, Type: Literature]
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34
[SID103457931]
Ki 0.0181Displacement of [3H]diprenorphine from rat kappa opioid receptor Y66A mutant expressed in HEK293 cells [AID317015, Type: Literature]
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35
[SID103457931]
Ki 0.0195Displacement of [3H]diprenorphine from rat kappa opioid receptor E297A mutant expressed in HEK293 cells [AID317026, Type: Literature]
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36
[SID103457931]
Ki 0.022Displacement of [3H]diprenorphine from rat kappa opioid receptor I62A mutant expressed in HEK293 cells [AID317014, Type: Literature]
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37
[SID103457931]
Ki 0.0253Displacement of [3H]diprenorphine from rat kappa opioid receptor K227A mutant expressed in HEK293 cells [AID317017, Type: Literature]
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38
[SID103457931]
Ki 0.0296Displacement of [3H]diprenorphine from rat kappa opioid receptor I290A mutant expressed in HEK293 cells [AID317018, Type: Literature]
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39
[SID103457931]
EC50 0.031Agonist activity at human KOPR expressed in U2OS cells assessed as beta-arrestin2 recruitment after 90 mins by DiscoveRx PathHunter assay [AID640395, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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40
[SID103457931]
Ki 0.037Displacement of [3H]diprenorphine from rat kappa opioid receptor Y313F mutant expressed in HEK293 cells [AID317030, Type: Literature]
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41
[SID103457931]
ED50 0.04Agonist activity at kappa opioid receptor assessed as stimulation of [35S]GTPgammaS binding [AID595424, Type: Literature]
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42
[SID103457931]
EC50 0.04Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as [35S]GTP-gamma-S binding after 3 hrs by liquid scintillation counting [AID659108, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
43
[SID103457931]
EC50 0.04Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells [AID240142, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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44
[SID103457931]
EC50 0.04Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay [AID329906, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
45
[SID103457931]
EC50 0.045Antagonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay [AID291861, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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46
[SID103457931]
EC50 0.045Agonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding [AID378997, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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47
[SID103457931]
EC50 0.046Effective concentration of compound against intracellular calcium mobilization in rat [AID246129, Type: Literature]
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48
[SID103457931]
Ki 0.067Displacement of [3H]diprenorphine from rat kappa opioid receptor Y119A mutant expressed in HEK293 cells [AID317022, Type: Literature]
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49
[SID103457931]
Ki 0.071Displacement of [3H]diprenorphine from rat kappa opioid receptor Y320F mutant expressed in HEK293 cells [AID317032, Type: Literature]
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50
[SID103457931]
Ki 0.079Displacement of [3H]diprenorphine from rat kappa opioid receptor Y312A mutant expressed in HEK293 cells [AID317027, Type: Literature]
View