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AGN-PC-0NK4IC (CID 12748881) - Compound BioActivity Data
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BioActivity Outcomes:
Active(78)
 
 
Inactive(437)
 
 
Inconclusive(21)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(27)
 
 
 
TRP 2(20)
 
 
 
Bcl-2 like(14)
 
 
 
NR LBD PPAR(12)
 
 
 
alkPPc(10)
 
 
BioAssay Types:
Screening(315)
 
 
 
 
Confirmatory(206)
 
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(146)
 
 
 
 
 
IC50(29)
 
 
 
EC50(26)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 493    Data Row: 537   Total Pages: 27   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24786281]
Potency 0.3981qHTS of Trypanosoma Brucei Inhibitors: Confirmatory Assay for Cherry-picked Compounds [AID720569, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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2
[SID24786281]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID24786281]
EC50_MICROM 0.56Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. [AID1320, Type: confirmatory]bcl-2-related protein A1 isoform 1 [Homo sapiens] [gi:4757840]
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4
[SID24786281]
Potency 0.5623qHTS of Trypanosoma Brucei Inhibitors: Orthogonal Assay for Cherry-picked Compounds [AID720584, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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5
[SID24786281]
Potency 0.7308qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID24786281]
EC50 1.003TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1679, Type: confirmatory]nuclear receptor coactivator 1 [Homo sapiens] [gi:152112968]
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7
[SID24786281]
EC50 1.003TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1679, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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8
[SID24786281]
EC50 2.231Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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9
[SID24786281]
Potency 3.1623qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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10
[SID24786281]
Potency 3.1623qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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11
[SID24786281]
Potency 3.1623qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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12
[SID24786281]
Potency 3.3587qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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13
[SID24786281]
Potency 3.9811qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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14
[SID24786281]
EC50 5.956Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C4 (TRPC4) [AID434942, Type: confirmatory]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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15
[SID24786281]
EC50 7.47Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
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16
[SID24786281]
Potency 8.9125HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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17
[SID24786281]
IC50 9.24uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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18
[SID24786281]
IC50_Mean 9.73Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID504719, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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19
[SID24786281]
Potency 10qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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20
[SID24786281]
Potency 10.3992qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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