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Methotrexate (CID 126941) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1486)
 
 
Inactive(884)
 
 
Inconclusive(231)
 
 
Unspecified(1348)
 
 
Top Targets:
DHFR(202)
 
 
 
7tm 4(67)
 
 
 
 
TS Pyrimidine..(57)
 
 
 
 
p450(27)
 
 
 
 
ABCC MRP doma..(27)
 
 
BioAssay Types:
Literature(1729)
 
 
 
 
 
Confirmatory(1347)
 
 
 
 
 
Screening(348)
 
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
IC50(1233)
 
 
 
 
 
Potency(578)
 
 
 
 
 
EC50(90)
 
 
 
 
 
Ki(58)
 
 
 
Kd(18)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3574    Data Row: 3949   Total Pages: 198   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234169]
IC50 1e-11Compound was tested for its anticancer activity against HL-60 cells. [AID80965, Type: confirmatory]
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2
[SID104234169]
Ki 1e-11Inhibitory activity against dihydrofolate reductase (DHFR) of L-1210 cells [AID220536, Type: Literature]
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3
[SID104234169]
IC50 5e-11Compound was tested for its anticancer activity against human T-lymphocytic leukemia MOLT-4 cells. [AID105115, Type: confirmatory]
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4
[SID104234169]
IC50 2e-08Inhibition of the growth of Lactobacillus casei [AID95774, Type: Literature]
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5
[SID104234169]
Ki 3.4e-07Inhibition of human DHFR by spectrophotometric analysis [AID708604, Type: Literature]Dihydrofolate reductase [gi:118992]
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6
[SID104234169]
Ki 1.2e-06Inhibitory activity against Wild-type human DHFR [AID219254, Type: Literature]
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7
[SID104234169]
Ki 3e-06Competitive inhibition of mouse DHFR by enzyme kinetics assay in presence of variable DHFA level [AID452315, Type: Literature]Dihydrofolate reductase [gi:1706542]
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8
[SID104234169]
Ki 3.2e-06Compound was evaluated for inhibitory activity against DHFR in L1210 cells [AID99054, Type: Literature]
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9
[SID104234169]
Ki 3.2e-06Tested for inhibition of dihydrofolate reductase enzyme [AID57460, Type: Literature]
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10
[SID104234169]
Ki 4e-06Inhibition constant of compound against Lactobacillus casei Dihydrofolate reductase [AID57776, Type: Literature]Dihydrofolate reductase [gi:7227951]
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11
[SID104234169]
Ki 4.3e-06Inhibition of Dihydrofolate reductase in mouse L1210 cells [AID57446, Type: Literature]Dihydrofolate reductase [gi:1706542]
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12
[SID104234169]
Ki 4.42e-06Compound was evaluated for binding affinity against Dihydrofolate reductase of L1210 cells [AID57447, Type: Literature]
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13
[SID104234169]
Ki 4.82e-06In vitro inhibition of dihydrofolate reductase (DHFR) in L1210 cells [AID57449, Type: Literature]
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14
[SID104234169]
Ki 4.82e-06Inhibitory activity of Dihydrofolate reductase in L1210 cells [AID57458, Type: Literature]
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15
[SID104234169]
IC50 5e-06Inhibition of L1210 cultured murine leukemia cell growth [AID98338, Type: Literature]
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16
[SID104234169]
Ki 5.19e-06Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uM [AID57132, Type: Literature]
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17
[SID104234169]
Ki 5.28e-06The compound was tested for its inhibitory activity against Dihydrofolate reductase derived from L1210 cells. [AID57462, Type: Literature]
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18
[SID104234169]
Ki 5.45e-06Evaluated for inhibition of dihydrofolate reductase (DHFR) isolated from L1210 cells [AID57452, Type: Literature]
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19
[SID104234169]
Ki 5.48e-06Compound was evaluated for inhibitory effect on dihydrofolate reductase (DHFR) from L1210 cells at Inhibitory constant (n=3) [AID57448, Type: Literature]
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20
[SID104234169]
Ki 5.6e-06Concentration inhibiting dihydrofolate reductase derived from L1210 cells [AID57451, Type: Literature]
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