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ethyl 4-{[(5-phenyl-2H-tetrazol-2-yl)acetyl]amino}benzoate (CID 1267856) - Compound BioActivity Data
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BioActivity Outcomes:
Active(14)
 
 
Inactive(819)
 
 
Inconclusive(21)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(28)
 
 
 
7TM GPCR Srsx(25)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(573)
 
 
 
 
 
Confirmatory(257)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(167)
 
 
 
 
 
IC50(52)
 
 
 
EC50(16)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 791    Data Row: 857   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID126920242]
EC50_MICROM 0.123Counter screen for HTS for Beta-2AR agonists with FAP-tagged human CCR5 with Powderset2 [AID651728, Type: confirmatory]CCR5 [Homo sapiens] [gi:289466095]
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2
[SID126920242]
EC50_MICROM 0.134Counter screen for HTS for Beta-2AR agonists with FAP-tagged GPR32 with Powderset2 [AID651729, Type: confirmatory]G protein-coupled receptor 32 [Homo sapiens] [gi:119592304]
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3
[SID4244167]
EC50_MICROM 1.18Dose response for HTS for Beta-2AR agonists via FAP method from CP1 [AID588763, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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4
[SID126920242]
EC50_MICROM 1.31Dose response for HTS for Beta-2AR agonists via FAP method from Powderset2 [AID623882, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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5
[SID4244167]
Potency 25.1189qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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6
[SID4244167]
HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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7
[SID4244167]
HTS for Beta-2AR agonists via FAP method, Single Point, Cherry Pick 1 [AID540358, Type: other]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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8
[SID4244167]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]5-hydroxytryptamine receptor 2A [Mus musculus] [gi:27753985]
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9
[SID4244167]
KCNQ2 Counter screen for inhibitors that protect hERG from block by proarrhythmic agents [AID1946, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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10
[SID4244167]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1531, Type: screening]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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11
[SID4244167]
Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
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12
[SID4244167]
Primary HTS assay during TNFalpha stimulated VCAM1 expression to assess cytotoxicity. [AID848, Type: other]vascular cell adhesion protein 1 isoform a precursor [Homo sapiens] [gi:4507875]
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13
[SID4244167]
Primary HTS assay for chemical inhibitors of TNF alpha stimulated VCAM1 expression [AID802, Type: screening]
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14
[SID4244167]
Anti-Viral Drugs Against Arbovirus Infections, a Primary Screen [AID1251, Type: screening]
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15
[SID4244167]
Potency 39.8107qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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16
[SID4244167]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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17
[SID4244167]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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18
[SID4244167]
Potency 3.5481qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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19
[SID4244167]
Potency 8.9125qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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20
[SID4244167]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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21
[SID4244167]
Full deck counterscreen for positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602247, Type: screening]
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22
[SID4244167]
Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
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23
[SID4244167]
Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
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24
[SID4244167]
uHTS luminescent assay for identification of compounds that enhance the survival of human induced pluripotent stem cells when cultured as single cells [AID602274, Type: screening]
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25
[SID4244167]
HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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26
[SID4244167]
Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_Activity [AID588436, Type: screening]
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27
[SID4244167]
uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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28
[SID4244167]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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29
[SID4244167]
Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588692, Type: screening]
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30
[SID4244167]
IC50 A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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31
[SID4244167]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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32
[SID4244167]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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33
[SID4244167]
Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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34
[SID4244167]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening] [geneid:2395]
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35
[SID4244167]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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36
[SID4244167]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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37
[SID4244167]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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38
[SID4244167]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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39
[SID4244167]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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40
[SID4244167]
Primary Cell Based High Throughput Screening Assay for Antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) [AID571, Type: screening]5-hydroxytryptamine receptor 1E [gi:112822]
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41
[SID4244167]
Primary Cell Based High Throughput Screening Assay for Agonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) [AID574, Type: screening]5-hydroxytryptamine receptor 1E [gi:112822]
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42
[SID4244167]
Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary Screen [AID628, Type: screening]Muscarinic acetylcholine receptor M1 [gi:113121]
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43
[SID4244167]
Potency qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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44
[SID4244167]
RNA polymerase [AID559, Type: screening]RNA polymerase beta subunit (EC 2.7.7.6), partial [Escherichia coli] [gi:147728]
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45
[SID4244167]
Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary Assay [AID1020, Type: screening]glucose-6-phosphate dehydrogenase [Leuconostoc mesenteroides] [gi:149631]
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46
[SID4244167]
Potency qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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47
[SID4244167]
Potency qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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48
[SID4244167]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID758, Type: screening]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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49
[SID4244167]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
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50
[SID4244167]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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