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STK218937 (CID 1262634) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Inactive(724)
 
 
Inconclusive(20)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(25)
 
 
7TM GPCR Srsx(20)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(10)
 
 
Tryp SPc(9)
 
 
BioAssay Types:
Screening(519)
 
 
 
 
 
Confirmatory(223)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(147)
 
 
 
 
 
IC50(47)
 
 
 
EC50(23)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 692    Data Row: 759   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14746391]
IC50 0.15203Counterscreen for NR2E3 inverse agonists: TR-FRET-based biochemical high throughput dose response assay to identify inverse agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) [AID463257, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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2
[SID14746391]
IC50 0.15203Counterscreen for NR2E3 inverse agonists: TR-FRET-based biochemical high throughput dose response assay to identify inverse agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) [AID463257, Type: confirmatory]nuclear receptor corepressor 2 isoform 2 [Homo sapiens] [gi:116256445]
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3
[SID14746391]
IC50 0.16727TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists [AID463256, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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4
[SID14746391]
Potency 12.5893qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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5
[SID14746391]
HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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6
[SID14746391]
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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7
[SID14746391]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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8
[SID14746391]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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9
[SID87339003]
Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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10
[SID14746391]
High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor [AID827, Type: screening]
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11
[SID14746391]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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12
[SID14746391]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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13
[SID14746391]
High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression [AID818, Type: screening]
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14
[SID14746391]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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15
[SID14746391]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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16
[SID14746391]
EC50 13.26Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1319, Type: confirmatory]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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17
[SID14746391]
EC50 13.26Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1319, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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18
[SID14746391]
EC50 14.54Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1323, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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19
[SID14746391]
EC50 14.54Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1323, Type: confirmatory]NCOA2 protein [Homo sapiens] [gi:62201602]
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20
[SID14746391]
EC50 18.28Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1331, Type: confirmatory]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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21
[SID14746391]
EC50 18.28Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1331, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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22
[SID14746391]
Potency 18.526Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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23
[SID85839623]
Luminescence Homogenous Primary HTS to Identify Inhibitors of STK33 Activity [AID2322, Type: screening]
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24
[SID14746391]
HTS to identify inhibitors of TNF-alpha Induced Cell Death in Jurkat FADD-/- Cells. [AID463075, Type: screening]
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25
[SID14746391]
Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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26
[SID14746391]
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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27
[SID14746391]
384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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28
[SID14746391]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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29
[SID14746391]
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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30
[SID14746391]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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31
[SID14746391]
uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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32
[SID14746391]
Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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33
[SID14746391]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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34
[SID14746391]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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35
[SID14746391]
uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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36
[SID14746391]
IC50 A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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37
[SID14746391]
Potency qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells [AID2685, Type: confirmatory]
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38
[SID14746391]
A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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39
[SID14746391]
Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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40
[SID14746391]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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41
[SID14746391]
Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
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42
[SID14746391]
Conc @ Max Fold Increase A high-throughput screen to identify small molecule compounds that augment HSV replication [AID1956, Type: confirmatory]
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43
[SID14746391]
Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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44
[SID14746391]
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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45
[SID14746391]
Potency qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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46
[SID14746391]
Potency qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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47
[SID14746391]
Luminescence-based counterscreen assay for KLF5 inhibitors: cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1825, Type: screening]
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48
[SID14746391]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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49
[SID14746391]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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50
[SID14746391]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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