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4-hydroxybenzaldehyde (CID 126) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(16)
 
 
Inconclusive(1)
 
 
Unspecified(45)
 
 
Top Targets:
Tyrosinase(5)
 
 
Pyr redox dim(2)
 
 
PLDc mTdp1 2(2)
 
 
ANK(2)
 
 
OAT like(2)
 
 
BioAssay Types:
Literature(55)
 
 
 
 
 
Confirmatory(15)
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(15)
 
 
 
IC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 71    Data Row: 71   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176078]
IC50 16.5Inhibitory activity against GABAT [AID260086, Type: Literature]4-aminobutyrate aminotransferase, mitochondrial [gi:48429239]
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2
[SID103176078]
IC50 16.5Inhibition of GABA transaminase in rat brain by Kitz-Wilson plot [AID368244, Type: Literature]4-aminobutyrate aminotransferase, mitochondrial [gi:122065191]
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3
[SID103176078]
IC50 24.7Inhibitory activity against SSADH [AID260087, Type: Literature]Succinate-semialdehyde dehydrogenase, mitochondrial [gi:7531278]
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4
[SID46392322]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Old Yellow Enzyme Mutant Gln114asn Complexed With Para-Hydroxy Benzaldehyde [gi:15988210]
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5
[SID103176078]
Deterrent activity against Perknaster fuscus assessed as induction of sustained retractions of tube-feet by sea-star deterrent assay [AID399372, Type: Literature]
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6
[SID103176078]
Cytotoxicity against human HT-29 cells at 10 to 100 uM after 48 hrs by MTT assay [AID648326, Type: Literature]
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7
[SID103176078]
Cytotoxicity against human HCT116 cells at 10 to 100 uM after 48 hrs by MTT assay [AID648327, Type: Literature]
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8
[SID103176078]
Cytotoxicity against human A549 cells at 10 to 100 uM after 48 hrs by MTT assay [AID648328, Type: Literature]
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9
[SID103176078]
Cytotoxicity against human MCF7 cells at 10 to 100 uM after 48 hrs by MTT assay [AID648329, Type: Literature]
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10
[SID103176078]
ED50 100Antiproliferative activity against mouse Colon 26-L5 cells by MTT assay [AID358852, Type: Literature]
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11
[SID103176078]
ED50 100Antiproliferative activity against human HT1080 cells by MTT assay [AID358853, Type: Literature]
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12
[SID103176078]
MIC 368.85Antitubercular activity against Mycobacterium tuberculosis 90-221387 [AID403754, Type: Literature]
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13
[SID103176078]
MIC 400Antitubercular activity against Mycobacterium tuberculosis 90-221387 [AID278000, Type: Literature]
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14
[SID103176078]
IC50 1000Inhibition of AChE [AID294501, Type: Literature]
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15
[SID103176078]
IC50 1120Inhibition of mushroom tyrosinase assessed as 3,4-dihydroxy-L-phenylalanine oxidation [AID411681, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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16
[SID103176078]
IC50 1220Inhibition of mushroom tyrosinase [AID436860, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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17
[SID103176078]
IC50 1220Inhibition of mashroom tyrosinase assessed as oxidation of L-DOPA by spectrophotometry [AID442500, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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18
[SID103176078]
IC50 3120Inhibition of pieris rapae Phenoloxidase [AID293934, Type: Literature]
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19
[SID103176078]
IC50 20000Inhibitory activity on germination of Bacillus subtilis PCI219 spores was determined. [AID40623, Type: Literature]
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20
[SID103176078]
Inhibition of Bacillus subtilis PCI219 spore germination, expressed as log 1/I50 [AID40936, Type: Literature]
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21
[SID103176078]
Antimicrobial activity against Staphylococcus aureus at 100 ug after 18 hrs by paper disk agar diffusion method [AID337973, Type: Literature]
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22
[SID103176078]
Antimicrobial activity against Candida albicans at 100 ug after 18 hrs by paper disk agar diffusion method [AID337974, Type: Literature]
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23
[SID103176078]
Antimicrobial activity against Candida tropicalis at 100 ug after 18 hrs by paper disk agar diffusion method [AID337975, Type: Literature]
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24
[SID103176078]
Binding affinity to beta cyclodextrin [AID346025, Type: Literature]
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25
[SID103176078]
Cytotoxicity against human KB cells [AID354806, Type: Literature]
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26
[SID103176078]
Antiplasmodial activity against Plasmodium falciparum D6 [AID354807, Type: Literature]
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27
[SID103176078]
Selectivity index, ratio of IC50 for human KB cells to IC50 for Plasmodium falciparum D6 [AID354808, Type: Literature]
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28
[SID103176078]
Antiplasmodial activity against Plasmodium falciparum W2 [AID354809, Type: Literature]
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29
[SID103176078]
Selectivity index, ratio of IC50 for human KB cells to IC50 for Plasmodium falciparum W2 [AID354810, Type: Literature]
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30
[SID103176078]
Partition coefficient (logP) [AID23251, Type: Literature]
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31
[SID103176078]
Partition coefficient (logP) (benzene) [AID23252, Type: Literature]
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32
[SID103176078]
Partition coefficient (logP) (carbon tetrachloride) [AID23253, Type: Literature]
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33
[SID103176078]
Partition coefficient (logP) (chloroform) [AID23254, Type: Literature]
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34
[SID103176078]
Partition coefficient (logP) (ether) [AID23255, Type: Literature]
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35
[SID103176078]
Partition coefficient (logP) (hexane) [AID23256, Type: Literature]
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36
[SID103176078]
Dissociation constant (pKa) [AID25611, Type: Literature]
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37
[SID103176078]
Partition coefficient (logD7.2) [AID26261, Type: Literature]
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38
[SID103176078]
Partition coefficient (logP) [AID26793, Type: Literature]
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39
[SID103176078]
Inhibition of GABA transaminase [AID383237, Type: Literature]
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40
[SID103176078]
Activity against caspase-mediated apoptosis in mouse L1210 cells at 0.1 mM [AID282833, Type: Literature]
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41
[SID103176078]
IC50 Cytotoxicity against mouse L1210 cells [AID282835, Type: Literature]
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42
[SID103176078]
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 30 uM after 72 hrs [AID462333, Type: Literature]
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43
[SID103176078]
Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 1 uM in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay [AID462339, Type: Literature]
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44
[SID103176078]
Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 3 uM in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay [AID462340, Type: Literature]
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45
[SID103176078]
Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 10 uM in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay [AID462341, Type: Literature]
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46
[SID103176078]
Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 30 uM in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay [AID462342, Type: Literature]
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47
[SID103176078]
Antiplatelet activity in human whole blood assessed as inhibition of collagen-induced platelet aggregation at 100 ug/mL relative to control [AID399387, Type: Literature]
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48
[SID103176078]
Antiplatelet activity in human whole blood assessed as inhibition of ADP-induced platelet aggregation at 100 ug/mL relative to control [AID399388, Type: Literature]
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49
[SID103176078]
Antiplatelet activity in human whole blood assessed as inhibition of arachidonic acid-induced platelet aggregation at 100 ug/mL relative to control [AID399389, Type: Literature]
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50
[SID103176078]
Antiplatelet activity in human whole blood assessed as inhibition of ristocetin-induced platelet aggregation at 100 ug/mL relative to control [AID399390, Type: Literature]
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