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5-{[3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylquinoxalin-2-yl]amino}-1,3-dihydro-2H-benzimidazol-2-one (CID 1253520) - Compound BioActivity Data
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BioActivity Outcomes:
Active(29)
 
 
Inactive(768)
 
 
Inconclusive(36)
 
 
Unspecified(3)
 
 
Top Targets:
7tm 4(54)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
PTPc(8)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(545)
 
 
 
 
 
Confirmatory(252)
 
 
 
 
 
Literature(12)
 
 
 
BioActivity Types:
Potency(169)
 
 
 
 
 
IC50(46)
 
 
 
EC50(11)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 761    Data Row: 836   Total Pages: 42   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4262936]
Potency 0.8492qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID4262936]
Potency 3.9811qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID4262936]
Absolute IC50 (CHOP) 6.47CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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4
[SID4262936]
Absolute IC50 (XBP1) 10XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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5
[SID4262936]
Potency 11.2202Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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6
[SID4262936]
Potency 17.7828qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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7
[SID4262936]
Active Concentration 20Modulators of the EP2 prostaglandin EP2 receptor - Primary Dose Response [AID1421, Type: confirmatory]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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8
[SID4262936]
Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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9
[SID4262936]
Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay [AID1488, Type: other]Muscarinic acetylcholine receptor M1 [gi:113121]
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10
[SID4262936]
Luminescence-based cell-based high throughput confirmation assay for biased ligands (agonists) of the melanocortin 4 receptor (MC4R) [AID602192, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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11
[SID4262936]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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12
[SID4262936]
Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID681, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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13
[SID4262936]
Pyruvate Kinase [AID361, Type: confirmatory]pyruvate kinase [Geobacillus stearothermophilus] [gi:285623]
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14
[SID4262936]
Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID560, Type: screening]Nuclear receptor ROR-alpha [gi:548814]
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15
[SID4262936]
Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [AID626, Type: screening]
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16
[SID4262936]
Screening for Modulators of Post-Golgi Transport, Control Strain [AID738, Type: screening]
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17
[SID4262936]
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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18
[SID162008294]
Confirmed Agonists of Novel Allosteric Modulators of the M1 Muscarinic Receptor [AID652178, Type: Literature]
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19
[SID4262936]
CHOP Confirmatory Screen [AID504437, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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20
[SID4262936]
qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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