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ethyl 5,5-dimethyl-2-(thiophene-2-carbonylamino)-4,7-dihydrothieno[2,3-c]pyran-3-carboxylate (CID 1251136) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(793)
 
 
Inconclusive(28)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(48)
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(542)
 
 
 
 
Confirmatory(258)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(169)
 
 
 
 
 
IC50(54)
 
 
EC50(12)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 760    Data Row: 833   Total Pages: 42   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4258750]
Potency 0.1qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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2
[SID4258750]
Potency 7.9433qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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3
[SID4258750]
Potency 9.2qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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4
[SID4258750]
Potency 25.929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID4258750]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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6
[SID4258750]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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7
[SID4258750]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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8
[SID4258750]
Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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9
[SID4258750]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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10
[SID4258750]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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11
[SID4258750]
Factor XIa Mixture HTS [AID680, Type: screening]coagulation factor XI [Homo sapiens] [gi:180352]
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12
[SID4258750]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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13
[SID4258750]
Potency 14.1254qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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14
[SID4258750]
Potency 19.9526qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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15
[SID87225467]
IC50_Mean 20SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens] [gi:11545912]
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16
[SID87225467]
IC50_Mean 20SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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17
[SID87225467]
IC50_Mean 20SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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18
[SID87225467]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
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19
[SID4258750]
Potency 25.1189qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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20
[SID4258750]
Potency 28.1838qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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