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Glutathione (CID 124886) - Compound BioActivity Data
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BioActivity Outcomes:
Active(17)
 
 
Inactive(111)
 
 
Inconclusive(29)
 
 
Unspecified(55)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
LYZ1(8)
 
 
NR LBD ER(7)
 
 
NR LBD AR(7)
 
 
ABCC MRP doma..(6)
 
 
BioAssay Types:
Confirmatory(69)
 
 
 
Literature(57)
 
 
 
 
Summary(24)
 
 
Screening(6)
 
 
BioActivity Types:
Potency(87)
 
 
 
IC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 209    Data Row: 212   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103569245]
IC50 0.02Affinity towards recombinant Glutathione S-transferase (GST) Enzyme. [AID75134, Type: Literature]
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2
[SID103569245]
Effect on CU2+-mediated superoxide-dependent cytochrome c reduction at 10 to 30 uM [AID390220, Type: Literature]
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3
[SID103569245]
Effect on CU2+-mediated superoxide-dependent cytochrome c reduction at 10 uM preincubated for 30 mins in presence of superoxide dismutase [AID390221, Type: Literature]
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4
[SID103569245]
Effect on CU2+-mediated superoxide-dependent lucigenin reduction by chemiluminescence assay at 10 to 30 uM [AID390222, Type: Literature]
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5
[SID103569245]
Antioxidant activity assessed as ABTS radical scavenging activity at 4 uM after 3 mins in presence of Cu2+ [AID390226, Type: Literature]
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6
[SID103569245]
Antioxidant activity assessed as DPPH radical scavenging activity at 36 uM after 3 mins in presence of Cu2++ [AID390227, Type: Literature]
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7
[SID103569245]
Decrease in glutathione content in liver of BALB/c mouse at 220 mg/kg/day, ip measured after 20 days [AID520297, Type: Literature]
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8
[SID103569245]
Decrease in glutathione content in heart of BALB/c mouse at 220 mg/kg/day, ip measured after 20 days [AID520298, Type: Literature]
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9
[SID103569245]
Decrease in glutathione content in blood of BALB/c mouse at 220 mg/kg/day, ip measured after 20 days [AID520299, Type: Literature]
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10
[SID103569245]
Decrease in glutathione content in kidney of BALB/c mouse at 220 mg/kg/day, ip measured after 20 days [AID520300, Type: Literature]
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11
[SID103569245]
Inhibition of Angeli's salt induced- vasodilatory activity in Sprague-Dawley rat thoracic aorta at 0.1 to 1 mM [AID577804, Type: Literature]
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12
[SID103569245]
Inhibition of 1-Nitrosocyclohexyl trifluoroacetate induced- vasodilatory activity in Sprague-Dawley rat thoracic aorta at 0.1 to 1 mM [AID577805, Type: Literature]
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13
[SID48416060]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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14
[SID46392774]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, 28kda Glutathione S-Transferase From Schistosoma Haematobium [gi:34810137]
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15
[SID46392775]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, 28kda Glutathione S-transferase From Schistosoma Haematobium (glutathione Saturated) [gi:34810139]
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16
[SID46393050]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Mitochondrial Class Kappa Glutathione Transferase [gi:42543493]
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17
[SID46392415]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of A Recombinant Glutathione Transferase, Created By Replacing The Last Seven Residues Of Each Subunit Of The Human Class Pi Isoenzyme With The Additional C-Terminal Helix Of Human Class Alpha Isoenzyme [gi:20664358]
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18
[SID103569245]
IC50 96Antioxidant activity assessed as DPPH free radical scavenging activity by UV spectroscopic method [AID447535, Type: Literature]
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19
[SID103569245]
Km 5000Activity of MRP1 [AID370723, Type: Literature]
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20
[SID103569245]
IC50 20000Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay [AID695876, Type: Literature]
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21
[SID103569245]
IC50 20000Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay [AID695877, Type: Literature]
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22
[SID103569245]
Km TP_TRANSPORTER: uptake in membrane vesicle from MRP3-expressing Sf9 cells [AID679298, Type: other]Multidrug resistance associated protein [gi:74761045]
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23
[SID103569245]
Dissociation constant, pKa of the compound [AID410195, Type: Literature]
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24
[SID103569245]
Dissociation constant, pKa of the compound [AID637281, Type: Literature]
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25
[SID103569245]
Renaturation of 0.1 mg/mL reduced hen egg white lysozyme assessed as maximum enzyme activity at 7 mM at pH 7 by Micrococcus lysodeikticus lysis-based enzyme assay in presence of 2 mM GSSG [AID637242, Type: Literature]Lysozyme C [gi:126608]
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26
[SID103569245]
Renaturation of 0.1 mg/mL reduced hen egg white lysozyme assessed as maximum enzyme activity at 7 mM at pH 8 by Micrococcus lysodeikticus lysis-based enzyme assay in presence of 2 mM GSSG [AID637278, Type: Literature]Lysozyme C [gi:126608]
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27
[SID103569245]
Renaturation of 0.1 mg/mL reduced hen egg white lysozyme assessed as apparent rate of renaturation at 7 mM at pH 7 by Micrococcus lysodeikticus lysis-based enzyme assay in presence of 2 mM GSSG [AID637284, Type: Literature]Lysozyme C [gi:126608]
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28
[SID103569245]
Renaturation of 0.1 mg/mL reduced hen egg white lysozyme assessed as apparent rate of renaturation at 7 mM at pH 8 by Micrococcus lysodeikticus lysis-based enzyme assay in presence of 2 mM GSSG [AID637290, Type: Literature]Lysozyme C [gi:126608]
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29
[SID103569245]
Renaturation of 1 mg/mL reduced hen egg white lysozyme assessed as maximum enzyme activity at 7 mM at pH 7 by Micrococcus lysodeikticus lysis-based enzyme assay in presence of 2 mM GSSG [AID637341, Type: Literature]Lysozyme C [gi:126608]
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30
[SID103569245]
Renaturation of 1 mg/mL reduced hen egg white lysozyme assessed as maximum enzyme activity at 7 mM at pH 8 by Micrococcus lysodeikticus lysis-based enzyme assay in presence of 2 mM GSSG [AID637342, Type: Literature]Lysozyme C [gi:126608]
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31
[SID103569245]
Renaturation of 1 mg/mL reduced hen egg white lysozyme assessed as apparent rate of renaturation at 7 mM at pH 7 by Micrococcus lysodeikticus lysis-based enzyme assay in presence of 2 mM GSSG [AID637343, Type: Literature]Lysozyme C [gi:126608]
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32
[SID103569245]
Renaturation of 1 mg/mL reduced hen egg white lysozyme assessed as apparent rate of renaturation at 7 mM at pH 8 by Micrococcus lysodeikticus lysis-based enzyme assay in presence of 2 mM GSSG [AID637344, Type: Literature]Lysozyme C [gi:126608]
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33
[SID103569245]
Antioxidant activity assessed as oxygen radical absorbance capacity index value by fluorescein protection assay [AID389190, Type: Literature]
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34
[SID103569245]
Antioxidant activity assessed as oxygen radical absorbance capacity index value at 10 uM by pyrogallol red protection assay [AID389193, Type: Literature]
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35
[SID103569245]
Antioxidant activity assessed as reducing capacity of DTNB at 20 uM after 30 mins in presence of Cu2++ [AID390209, Type: Literature]
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36
[SID103569245]
Antioxidant activity assessed as reducing capacity of Iodine solution at 0.25mM after 30 mins in presence of Cu2++ [AID390210, Type: Literature]
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37
[SID103569245]
Antioxidant activity assessed as ABTS radical scavenging activity at 4 uM after 30 mins in presence of Cu2++ [AID390211, Type: Literature]
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38
[SID103569245]
Antioxidant activity assessed as DPPH radical scavenging activity at 36 uM after 30 mins in presence of Cu2++ [AID390212, Type: Literature]
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39
[SID103569245]
Induction of ascorbic acid oxidation preincubated for 3 mins in presence of Cu2++ [AID390216, Type: Literature]
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40
[SID103569245]
Induction of ascorbic acid oxidation preincubated for 30 mins in presence of Cu2++ [AID390217, Type: Literature]
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41
[SID103569245]
Induction of ascorbic acid oxidation preincubated for 60 mins in presence of Cu2++ [AID390218, Type: Literature]
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42
[SID103569245]
Induction of ascorbic acid oxidation preincubated for 300 mins in presence of Cu2++ [AID390219, Type: Literature]
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43
[SID103569245]
Dissociation constant, pKa of the compound [AID316417, Type: Literature]
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44
[SID103569245]
Effect on reduced chicken lysozyme folding activity assessed as maximal activity at 2 mM at pH 8.2 [AID316421, Type: Literature]
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45
[SID103569245]
Protection against photoirradiation-induced lipid peroxidation damage in rat liver mitochondria at 10 mM [AID323194, Type: Literature]
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46
[SID103569245]
Inhibition of human MRP1 mediated LTC4 transport in hamster BHK21 cells in presence of glutathione by rapid filtration technique [AID360084, Type: Literature]
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47
[SID103569245]
Antimicrobial activity against Mycobacterium bovis BCG KOP55 harboring inactivated p55 gene at 10 umol after 14 days by disk diffusion method [AID564961, Type: Literature]
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48
[SID103569245]
Antimicrobial activity against Mycobacterium bovis BCG P55 at 10 umol after 14 days by disk diffusion method [AID564964, Type: Literature]
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49
[SID103569245]
Antioxidant activity assessed as ABTS radical scavenging activity after 30 mins in absence of Cu2+ [AID390224, Type: Literature]
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50
[SID103569245]
Antioxidant activity assessed as DPPH radical scavenging activity after 40 mins in absence of Cu2+ [AID390225, Type: Literature]
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