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ramatroban (CID 123879) - Compound BioActivity Data
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BioActivity Outcomes:
Active(34)
 
 
Inactive(181)
 
 
Inconclusive(6)
 
 
Unspecified(20)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
p450(6)
 
 
 
 
NR LBD VDR(5)
 
 
 
BioAssay Types:
Literature(111)
 
 
 
 
 
Confirmatory(104)
 
 
 
 
Summary(24)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(121)
 
 
 
 
IC50(23)
 
 
 
 
Ki(11)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 177    Data Row: 241   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103444835]
Ki 0.00058Binding affinity to thromboxane receptor [AID551275, Type: Literature]
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2
[SID103444835]
Ki 0.0043Inhibition of [3H]PGD-2 binding to human chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) [AID239567, Type: Literature]Prostaglandin D2 receptor 2 [gi:296439334]
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3
[SID103444835]
Ki 0.0045Inhibition of [3H]SQ-29,548 binding to human Thromboxane A2 receptor [AID238927, Type: Literature]Thromboxane A2 receptor [gi:229463010]
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4
[SID103444835]
IC50 0.0084Inhibition of beta-arrestin translocation at human Thromboxane A2 receptor in BRET assay [AID248580, Type: Literature]Thromboxane A2 receptor [gi:229463010]
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5
[SID103444835]
IC50 0.0096Inhibition of U-46,619-induced inositol phosphate accumulation at human Thromboxane A2 receptor [AID248754, Type: Literature]Thromboxane A2 receptor [gi:229463010]
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6
[SID144206069]
Potency 0.0103qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Counterscreen HTRF assay [AID651843, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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7
[SID144206069]
Potency 0.0103qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Counterscreen HTRF assay [AID651843, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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8
[SID50112772]
Potency 0.0116qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Initial hit validation in AlphaScreen assay for MBNL1-(CUG)12 binding [AID493205, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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9
[SID103444835]
Kd 0.01259Compound was tested for inhibition of U-46,619 induced contraction of isolated rabbit saphenous vein [AID166818, Type: Literature]
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10
[SID103444835]
IC50 0.014Displacement of [3H]SQ-29548 from thromboxane receptor in human platelet membrane [AID429618, Type: Literature]Thromboxane A2 receptor [gi:229463010]
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11
[SID50112772]
Potency 0.0163qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Initial hit validation from the primary screen [AID493199, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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12
[SID103444835]
Ki 0.018Inhibitory activity for binding of PGD-2 in hTP binding assay using HEK293 cell membranes [AID244585, Type: Literature]
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13
[SID103444835]
IC50 0.021Antagonist activity against CRTh2 receptor in human eosinophils assessed as cell shape change [AID431338, Type: Literature]Prostaglandin D2 receptor 2 [gi:296439334]
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14
[SID103444835]
IC50 0.028Inhibition of beta-arrestin translocation at human chemoattractant receptor-homologous molecule expressed on TH2 cells in BRET assay [AID248959, Type: Literature]Prostaglandin D2 receptor 2 [gi:296439334]
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15
[SID103444835]
IC50 0.029Inhibition of PGD2-induced inositol phosphate formation at human chemoattractant receptor-homologous molecule expressed on TH2 cells [AID248926, Type: Literature]Prostaglandin D2 receptor 2 [gi:296439334]
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16
[SID103444835]
IC50 0.05Anti-platelet activity was measured by studying their antagonist effects on human platelets aggregated with collagen [AID92808, Type: Literature]
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17
[SID103444835]
Ki 0.073Displacement of [3H]PGD2 from human CRTh2 receptor expressed in CHO cells [AID431337, Type: Literature]Prostaglandin D2 receptor 2 [gi:296439334]
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18
[SID103444835]
IC50 0.077Displacement of [3H]PGD2 from human CRTh2 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay [AID586985, Type: Literature]Prostaglandin D2 receptor 2 [gi:296439334]
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19
[SID103444835]
Ki 0.137Binding affinity to human recombinant CRTH2 receptor by cell based radioligand equilibrium competition assay [AID551273, Type: Literature]Prostaglandin D2 receptor 2 [gi:296439334]
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20
[SID103444835]
IC50 0.169Antagonist activity at human CRTH2 receptor assessed as inhibition of DK-PGD2-induced eosinophil chemotaxis [AID330825, Type: Literature]Prostaglandin D2 receptor 2 [gi:296439334]
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