Bookmark and Share
2-chloro-N(6)cyclopentyladenosine (CID 123807) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(64)
 
 
Inactive(38)
 
 
Inconclusive(1)
 
 
Unspecified(56)
 
 
Top Targets:
7TM GPCR Srsx(55)
 
 
 
 
PLDc mTdp1 2(3)
 
 
Tubulin-bindi..(2)
 
 
ANK(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Literature(123)
 
 
 
 
 
Confirmatory(33)
 
 
BioActivity Types:
Ki(55)
 
 
Potency(30)
 
 
EC50(9)
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 149    Data Row: 159   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103212393]
Ki 0.0003Displacement of [3H]CCPA from adenosine A1 receptor in pig cortical membrane [AID313256, Type: Literature]A1 adenosine receptor [gi:75068761]
View
2
[SID103212393]
Ki 0.00034Displacement of [3H]CCPA from adenosine A1 receptor in bovine cortical membrane [AID313255, Type: Literature]Adenosine receptor A1 [gi:160332359]
View
3
[SID103212393]
Ki 0.00035Inhibitory activity at Adenosine A1 receptor by inhibition of [3H]CHA binding to bovine brain cortical membranes. [AID32002, Type: Literature]
View
4
[SID103212393]
Ki 0.0006Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand [AID32177, Type: Literature]
View
5
[SID103212393]
Ki 0.0006Tested for the binding affinity of A1 receptor by displacing the [3H]-PIA in rat brain membranes [AID32513, Type: Literature]
View
6
[SID103212393]
Ki 0.0006Inhibition of [3H]- (R)-P1A binding to adenosine A1 receptor [AID32179, Type: Literature]Adenosine receptor A1 [gi:2827766]
View
7
[SID103212393]
Ki 0.0008Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells [AID313263, Type: Literature]Adenosine receptor A1 [gi:231473]
View
8
[SID103212393]
Ki 0.00083Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells [AID30461, Type: Literature]Adenosine receptor A1 [gi:231473]
View
9
[SID103212393]
Ki 0.00083Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A1 receptor in CHO cells [AID256760, Type: Literature]Adenosine receptor A1 [gi:231473]
View
10
[SID103212393]
Ki 0.001Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor. [AID32295, Type: Literature]Adenosine receptor A1 [gi:1351830]
View
11
[SID103212393]
IC50 0.0013Inhibition of cAMP formation in CHO cells expressing adenosine A1 receptor [AID30310, Type: Literature]Adenosine receptor A1 [gi:231473]
View
12
[SID103212393]
Ki 0.0013Displacement of [3H]CHA from Adenosine A1 receptor of rat brain [AID32634, Type: Literature]Adenosine receptor A1 [gi:2827766]
View
13
[SID103212393]
Ki 0.0013Affinity for adenosine A1 receptor assayed in a competition assay in rat brain using [3H]-CHA as radioligand [AID31721, Type: Literature]
View
14
[SID103212393]
Ki 0.0013Binding affinity against adenosine A1 receptor from rat brain using [3H]CHA as a radioligand. [AID31859, Type: Literature]
View
15
[SID103212393]
Ki 0.00133Displacement of [3H]R-PIA from rat brain membrane Adenosine A1 receptor [AID32358, Type: Literature]Adenosine receptor A1 [gi:2827766]
View
16
[SID103212393]
Ki 0.0015Tested for inhibition of adenosine A1 receptor binding to rat brain [AID32510, Type: other]
View
17
[SID103212393]
EC50 0.0046Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay [AID699043, Type: Literature]Adenosine receptor A1 [gi:231473]
View
18
[SID103212393]
Ki 0.0064In vitro binding affinity towards human adenosine A1 receptor by [3H]DPCPX displacement. [AID30905, Type: Literature]
View
19
[SID103212393]
Ki 0.00743Binding affinity for adenosine A1 receptor was assayed by displacement of [3H]DPCPX from rat cortical membranes. [AID32012, Type: Literature]
View
20
[SID103212393]
EC50 0.0082Negative chronotropic activity via A1 Adenosine receptor was tested in spontaneously beating rat atria [AID31266, Type: Literature]
View
21
[SID103212393]
EC50 0.0082Activitty at Adenosine A1 receptor of rat atria [AID31261, Type: Literature]Adenosine receptor A1 [gi:2827766]
View
22
[SID103212393]
Ki 0.00947Affinity towards adenosine A1 receptor from rat cortical membranes using [3H]DPCPX [AID31855, Type: Literature]
View
23
[SID103212393]
EC50 0.014Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay [AID699044, Type: Literature]Adenosine receptor A1 [gi:231473]
View
24
[SID103212393]
Ki 0.0151Binding affinity to human adenosine A1 receptor expressed in CHO cells [AID363482, Type: Literature]Adenosine receptor A1 [gi:231473]
View
25
[SID103212393]
Ki 0.0153Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 90 mins [AID703961, Type: Literature]Adenosine receptor A1 [gi:231473]
View
26
[SID103212393]
Ki 0.017In vitro inhibition of human neutrophil activation via Adenosine A2A receptor. [AID34844, Type: Literature]
View
27
[SID103212393]
EC50 0.03Stimulation of [35S]GTP-gamma-S, binding to rat brain membranes by adenosine A1 receptor activation [AID224979, Type: Literature]
View
28
[SID103212393]
Ki 0.03Inhibitory activity against Adenosine A3 receptor by inhibiting specific [3H](R)-PIA binding to rat testis membranes [AID33482, Type: Literature]
View
29
[SID103212393]
Ki 0.034Binding affinity in membrane of CHO cell stably expressing recombinant human Adenosine A3 receptor in the presence of GTPgammaS using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one as radioligand [AID34706, Type: Literature]
View
30
[SID103212393]
Ki 0.038Affinity for human Adenosine A3 receptor expressed in CHO cell [AID34574, Type: Literature]
View
31
[SID103212393]
Ki 0.038Bnding affinity in membrane of CHO cell stably expressing recombinant human Adenosine A3 receptor using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one as radioligand [AID34733, Type: Literature]
View
32
[SID103212393]
Ki 0.038Binding affinity to human adenosine A3 receptor in CHO cells [AID256762, Type: Literature]Adenosine receptor A3 [gi:1351831]
View
33
[SID103212393]
Ki 0.042Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity [AID313266, Type: Literature]Adenosine receptor A2b [gi:112938]
View
34
[SID103212393]
Ki 0.0423Displacement of [3H]NECA from human adenosine A3 receptor in stably transfected HEK cells [AID34735, Type: Literature]Adenosine receptor A3 [gi:1351831]
View
35
[SID103212393]
Ki 0.1Binding affinity towards Adenosine A3 receptor (W243 mutant receptor) [AID34719, Type: Literature]
View
36
[SID103212393]
Ki 0.114Binding affinity towards human Adenosine A3 receptor wild type [AID33507, Type: Literature]
View
37
[SID103212393]
Ki 0.204Affinity towards Adenosine A3 receptor expressed in HEK 293 cells using [125I]AB-MECA radioligand [AID34573, Type: Literature]
View
38
[SID103212393]
Ki 0.237Tested for the binding affinity of A3 receptor by displacing N6-[[125I]-4-amino-3-iodobenzyl]-adenosine-5''-N-methyluronamide from membranes of CHO cells transfected with rat A3-cDNA [AID33485, Type: Literature]
View
39
[SID103212393]
Ki 0.237Binding affinity to rat adenosine A3 receptor in CHO cells [AID256764, Type: Literature]Adenosine receptor A3 [gi:2506479]
View
40
[SID103212393]
Ki 0.237Displacement of [125I]- AB-MECA from rat adenosine A3 receptor expressed in HEK cells [AID33479, Type: Literature]Adenosine receptor A3 [gi:2506479]
View
41
[SID103212393]
Ki 0.281Inhibition of [125 I]-IABMECA binding to human adenosine A3 receptor [AID32772, Type: Literature]Adenosine receptor A3 [gi:1351831]
View
42
[SID103212393]
Ki 0.58Inhibitory activity at Adenosine A2A receptor by inhibition of [3H]-CGS- 21680 binding to bovine striatal membranes. [AID33928, Type: Literature]
View
43
[SID103212393]
Ki 0.605Displacement of specific [3H]-CGS- 21680 binding to adenosine A2A receptor in rat striatal membranes [AID32896, Type: Literature]Adenosine receptor A2a [gi:8928539]
View
44
[SID103212393]
Ki 0.639Tested for binding affinity towards human adenosine A2A receptor using [3H]ZM-241385 as radioligand [AID34681, Type: Literature]
View
45
[SID103212393]
Ki 0.64Binding affinity for adenosine A2A receptor was determined by displacement of [3H]-DPCPX from rat striatal membranes. [AID32863, Type: Literature]
View
46
[SID103212393]
Ki 0.65Affinity for the adenosine A2 receptor was evaluated in a competition assay in rat striatum using [3H]-CGS- 21680 as radioligand [AID33427, Type: Literature]
View
47
[SID103212393]
Ki 0.65Binding affinity against adenosine A2a receptor from rat striatum using [3H]-CGS- 21680 as a radioligand. [AID33790, Type: Literature]
View
48
[SID103212393]
Ki 0.65Displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatum [AID33943, Type: Literature]Adenosine receptor A2a [gi:8928539]
View
49
[SID103212393]
Ki 0.65Displacement of [3H]CGS21680 from adenosine A1 receptor in pig striatum membrane [AID313258, Type: Literature]A1 adenosine receptor [gi:75068761]
View
50
[SID103212393]
Ki 0.667Tested for inhibition of adenosine A2 receptor binding to rat brain [AID33741, Type: other]
View