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2-chloro-N(6)cyclopentyladenosine (CID 123807) - Compound BioActivity Data
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BioActivity Outcomes:
Active(65)
 
 
Inactive(38)
 
 
Inconclusive(1)
 
 
Unspecified(57)
 
 
Top Targets:
7TM GPCR Srsx(57)
 
 
 
 
PLDc mTdp1 2(3)
 
 
Tubulin-bindi..(2)
 
 
ANK(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Literature(125)
 
 
 
 
 
Confirmatory(35)
 
 
 
BioActivity Types:
Ki(55)
 
 
Potency(30)
 
 
EC50(10)
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 151    Data Row: 161   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103212393]
Ki 0.0003Displacement of [3H]CCPA from adenosine A1 receptor in pig cortical membrane [AID313256, Type: Literature]A1 adenosine receptor [gi:75068761]
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2
[SID103212393]
Ki 0.00034Displacement of [3H]CCPA from adenosine A1 receptor in bovine cortical membrane [AID313255, Type: Literature]Adenosine receptor A1 [gi:160332359]
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3
[SID103212393]
Ki 0.00035Inhibitory activity at Adenosine A1 receptor by inhibition of [3H]CHA binding to bovine brain cortical membranes. [AID32002, Type: Literature]
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4
[SID103212393]
Ki 0.0006Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand [AID32177, Type: Literature]
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5
[SID103212393]
Ki 0.0006Tested for the binding affinity of A1 receptor by displacing the [3H]-PIA in rat brain membranes [AID32513, Type: Literature]
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6
[SID103212393]
Ki 0.0006Inhibition of [3H]- (R)-P1A binding to adenosine A1 receptor [AID32179, Type: Literature]Adenosine receptor A1 [gi:2827766]
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7
[SID103212393]
Ki 0.0008Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells [AID313263, Type: Literature]Adenosine receptor A1 [gi:231473]
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8
[SID103212393]
Ki 0.00083Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells [AID30461, Type: Literature]Adenosine receptor A1 [gi:231473]
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9
[SID103212393]
Ki 0.00083Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A1 receptor in CHO cells [AID256760, Type: Literature]Adenosine receptor A1 [gi:231473]
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10
[SID103212393]
Ki 0.001Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor. [AID32295, Type: Literature]Adenosine receptor A1 [gi:1351830]
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11
[SID103212393]
IC50 0.0013Inhibition of cAMP formation in CHO cells expressing adenosine A1 receptor [AID30310, Type: Literature]Adenosine receptor A1 [gi:231473]
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12
[SID103212393]
Ki 0.0013Displacement of [3H]CHA from Adenosine A1 receptor of rat brain [AID32634, Type: Literature]Adenosine receptor A1 [gi:2827766]
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13
[SID103212393]
Ki 0.0013Affinity for adenosine A1 receptor assayed in a competition assay in rat brain using [3H]-CHA as radioligand [AID31721, Type: Literature]
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14
[SID103212393]
Ki 0.0013Binding affinity against adenosine A1 receptor from rat brain using [3H]CHA as a radioligand. [AID31859, Type: Literature]
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15
[SID103212393]
Ki 0.00133Displacement of [3H]R-PIA from rat brain membrane Adenosine A1 receptor [AID32358, Type: Literature]Adenosine receptor A1 [gi:2827766]
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16
[SID103212393]
Ki 0.0015Tested for inhibition of adenosine A1 receptor binding to rat brain [AID32510, Type: confirmatory]
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17
[SID103212393]
EC50 0.0046Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay [AID699043, Type: Literature]Adenosine receptor A1 [gi:231473]
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18
[SID103212393]
Ki 0.0064In vitro binding affinity towards human adenosine A1 receptor by [3H]DPCPX displacement. [AID30905, Type: Literature]
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19
[SID103212393]
Ki 0.00743Binding affinity for adenosine A1 receptor was assayed by displacement of [3H]DPCPX from rat cortical membranes. [AID32012, Type: Literature]
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20
[SID103212393]
EC50 0.0082Negative chronotropic activity via A1 Adenosine receptor was tested in spontaneously beating rat atria [AID31266, Type: Literature]
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