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gefitinib (CID 123631) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1008)
 
 
Inactive(530)
 
 
Inconclusive(103)
 
 
Unspecified(1410)
 
 
Top Targets:
PKc(100)
 
 
 
 
PTKc EGFR(82)
 
 
 
 
PKc like(79)
 
 
 
 
STKc AGC(43)
 
 
 
 
PTKc Abl(33)
 
 
 
 
 
BioAssay Types:
Literature(1549)
 
 
 
 
 
Confirmatory(781)
 
 
 
 
 
Screening(35)
 
 
 
Summary(25)
 
 
 
 
BioActivity Types:
Kd(882)
 
 
 
 
IC50(763)
 
 
 
 
Potency(169)
 
 
 
 
EC50(4)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2660    Data Row: 3051   Total Pages: 153   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103244983]
IC50 0.0001Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET based Z'-lyte assay [AID761603, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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2
[SID103244983]
IC50 0.0001Inhibition of wild type EGFR (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assay [AID748091, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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3
[SID103244983]
IC50 0.0002Inhibition of EGFR L858R mutant (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assay [AID748094, Type: Literature]
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4
[SID103244983]
IC50 0.0002Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET based Z'-lyte assay [AID761602, Type: Literature]
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5
[SID103244983]
Ki 0.0004Inhibition of EGFR [AID512580, Type: Literature]
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6
[SID103244983]
Kd 0.00052Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID435906, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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7
[SID103244983]
Kd 0.00052Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID625002, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
8
[SID103244983]
Kd 0.00054Binding constant for EGFR(E746-A750del) kinase domain [AID624997, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
9
[SID103244983]
Kd 0.00054Binding constant for EGFR(E746-A750del) kinase domain [AID435791, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
10
[SID103244983]
Kd 0.00057Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID435652, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
11
[SID103244983]
Kd 0.00057Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID435653, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
12
[SID103244983]
Kd 0.00057Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID625000, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
13
[SID103244983]
Kd 0.00057Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID625001, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
14
[SID103244983]
IC50 0.0006Inhibition of wild type human EGFR tyrosine kinase assessed as Ulight-CAGAGAIETDKEYYTVKD phosphorylation after 15 mins by time-resolved fluorometry [AID771345, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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15
[SID103244983]
Kd 0.00094Binding constant for EGFR(L858R) kinase domain [AID625003, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
16
[SID103244983]
Kd 0.00094Binding constant for EGFR(L858R) kinase domain [AID435525, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
17
[SID103244983]
Kd 0.00098Binding constant for EGFR(S752-I759del) kinase domain [AID625006, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
18
[SID103244983]
Kd 0.00098Binding constant for EGFR(S752-I759del) kinase domain [AID435792, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
19
[SID103244983]
Kd 0.001Binding constant for EGFR kinase domain [AID435156, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
20
[SID103244983]
Kd 0.001Binding constant for EGFR kinase domain [AID624996, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View