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imatinib (CID 123596) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(33)
 
 
Inactive(488)
 
 
Inconclusive(42)
 
 
Unspecified(14)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(13)
 
 
NR LBD PPAR(8)
 
 
 
NR LBD ER(7)
 
 
 
NR LBD AR(7)
 
 
 
 
BioAssay Types:
Screening(351)
 
 
 
 
Confirmatory(160)
 
 
 
 
 
Summary(24)
 
 
 
 
Literature(21)
 
 
 
 
BioActivity Types:
Potency(157)
 
 
 
 
 
IC50(21)
 
 
 
 
EC50(3)
 
 
 
AC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 532    Data Row: 577   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103619406]
EC50 0.09Antiproliferative activity against K562 cells expressing Bcr-Abl [AID266585, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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2
[SID103619406]
EC50 0.09Antiproliferative activity against K562 cells expressing Bcr-Abl [AID266585, Type: Literature]Breakpoint cluster region protein [gi:143811366]
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3
[SID103619406]
IC50 0.21Cytotoxicity against human K562 cells after 24 hrs by MTT assay [AID629493, Type: Literature]
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4
[SID103619406]
IC50 0.43Inhibition of c-ABL [AID266584, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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5
[SID103619406]
IC50 0.83Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay [AID629494, Type: Literature]
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6
[SID103619406]
IC50 1.7Growth inhibition of human GIST882 cells expressing c-Kit after 96 hrs by SRB assay [AID595155, Type: other]
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7
[SID103619406]
IC50 1.8Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay [AID629495, Type: Literature]
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8
[SID144205237]
Potency-Replicate_1 2.1132qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID144205237]
Ratio Potency (uM) 2.66032qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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10
[SID144205237]
Potency 3.9811qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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11
[SID144205237]
Potency-Replicate_1 11.8832qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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12
[SID144205237]
Potency-Replicate_1 13.3332qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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13
[SID144205237]
AhR Potency (uM) 13.8548qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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14
[SID144205237]
Potency-Replicate_1 14.9601qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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15
[SID49681833]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID49681833]
AC50_uM 18.97FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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17
[SID49681833]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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18
[SID49681833]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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19
[SID144205237]
Potency-Replicate_1 21.1317qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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20
[SID144205237]
Potency-Replicate_1 21.1317qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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21
[SID144205237]
Potency 23.715qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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22
[SID144205237]
Potency-Replicate_1 23.9145qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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23
[SID144205237]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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24
[SID170465393]
qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743240, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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25
[SID49681833]
FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651710, Type: screening]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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26
[SID49681833]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1531, Type: screening]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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27
[SID103619406]
Tyrosine-protein kinase ABL inhibitor [AID742811, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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28
[SID49681833]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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29
[SID103619406]
Stem cell growth factor receptor inhibitor [AID742849, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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30
[SID103619406]
Platelet-derived growth factor receptor beta inhibitor [AID742839, Type: other]Platelet-derived growth factor receptor beta [gi:129890]
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31
[SID103619406]
IC50 Inhibition of human JAK2 V617F mutant expressed in COS7 cells [AID360729, Type: Literature]
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32
[SID103619406]
Growth inhibition of human chronic myelogenous leukemia cells expressing BCR-ABL protein [AID360732, Type: Literature]
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33
[SID49681833]
Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_Activity [AID504558, Type: screening]LMP1 [Human herpesvirus 4] [gi:23893668]
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34
[SID103619406]
Inhibition of formation of erythroid burst-forming units in human polycythemia vera cells at 1 uM [AID360938, Type: Literature]
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35
[SID103619406]
Induction of apoptosis in human K562 cells after 48 hrs [AID396071, Type: Literature]
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36
[SID49681833]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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37
[SID103619406]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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38
[SID103619406]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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39
[SID103619406]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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40
[SID103619406]
Cell cycle arrest in human K562 cells assessed as accumulation at sub-G1 phase at 10 uM after 24 hrs by propidium iodide staining-based FACS analysis (Rvb = 0.27 +/- 0.04 %) [AID629496, Type: Literature]
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41
[SID103619406]
Cell cycle arrest in human K562 cells assessed as accumulation at G1 phase at 10 uM after 24 hrs by propidium iodide staining-based FACS analysis (Rvb = 74.25 +/- 1.511 %) [AID629497, Type: Literature]
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42
[SID103619406]
Cell cycle arrest in human K562 cells assessed as accumulation at S phase at 10 uM after 24 hrs by propidium iodide staining-based FACS analysis (Rvb = 11.23 +/- 0.8 %) [AID629498, Type: Literature]
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43
[SID103619406]
Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs by propidium iodide staining-based FACS analysis (Rvb = 14.24 +/- 0.76 %) [AID629499, Type: Literature]
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44
[SID103619406]
TP_TRANSPORTER: uptake in BCRP-expressing HEK cells [AID680974, Type: other]ATP-binding cassette sub-family G member 2 [gi:67462103]
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45
[SID103619406]
TP_TRANSPORTER: increase in Topotecan intracellular accumulation (Topotecan: 1 uM, Imanitib mesylate: 1 uM) in BCRP-expressing SaoS2 cells [AID682137, Type: other]ATP-binding cassette sub-family G member 2 [gi:67462103]
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46
[SID103619406]
Effect on human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles relative to control [AID404304, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:308153583]
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47
[SID103619406]
TP_TRANSPORTER: efflux in MDR1-expressing LLC-PK1 cells [AID680881, Type: other]Multidrug resistance protein 1 [gi:238054374]
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48
[SID49681833]
Potency 0.2818qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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49
[SID144205237]
Potency 0.631qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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50
[SID49681833]
Potency 1.122A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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