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imatinib (CID 123596) - Compound BioActivity Data
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BioActivity Outcomes:
Active(34)
 
 
Inactive(500)
 
 
Inconclusive(40)
 
 
Unspecified(496)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(13)
 
 
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
BioAssay Types:
Screening(352)
 
 
 
 
Confirmatory(163)
 
 
 
 
 
Literature(33)
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(158)
 
 
 
 
 
IC50(21)
 
 
 
 
AC50(3)
 
 
 
 
EC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1019    Data Row: 1070   Total Pages: 54   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103619406]
EC50 0.09Antiproliferative activity against K562 cells expressing Bcr-Abl [AID266585, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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2
[SID103619406]
EC50 0.09Antiproliferative activity against K562 cells expressing Bcr-Abl [AID266585, Type: Literature]Breakpoint cluster region protein [gi:143811366]
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3
[SID103619406]
IC50 0.21Cytotoxicity against human K562 cells after 24 hrs by MTT assay [AID629493, Type: Literature]
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4
[SID103619406]
IC50 0.43Inhibition of c-ABL [AID266584, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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5
[SID103619406]
IC50 0.83Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay [AID629494, Type: Literature]
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6
[SID103619406]
IC50 1.7Growth inhibition of human GIST882 cells expressing c-Kit after 96 hrs by SRB assay [AID595155, Type: confirmatory]
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7
[SID103619406]
IC50 1.8Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay [AID629495, Type: Literature]
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8
[SID144205237]
Potency-Replicate_1 2.1132qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID144205237]
Ratio Potency (uM) 2.66032qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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10
[SID144205237]
Potency 3.9811qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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11
[SID144205237]
Potency-Replicate_1 11.8832qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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12
[SID144205237]
Potency 12.5893qHTS Assay for Identifying Gametocytocidal Compounds [AID743244, Type: confirmatory]
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13
[SID144205237]
Potency-Replicate_1 13.3332qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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14
[SID144205237]
AhR Potency (uM) 13.8548qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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15
[SID144205237]
Potency-Replicate_1 14.9601qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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16
[SID49681833]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID49681833]
AC50_uM 18.97FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog isoform a [Homo sapiens] [gi:109637798]
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18
[SID49681833]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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19
[SID49681833]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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20
[SID144205237]
Potency-Replicate_1 21.1317qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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