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SMR000229280 (CID 1230852) - Compound BioActivity Data
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BioActivity Outcomes:
Active(28)
 
 
Inactive(662)
 
 
Inconclusive(27)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(20)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
7TM GPCR Srv(9)
 
 
 
BioAssay Types:
Screening(482)
 
 
 
 
Confirmatory(215)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(148)
 
 
 
 
 
IC50(39)
 
 
 
 
EC50(18)
 
 
 
AC50(5)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 654    Data Row: 718   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID22413484]
AC50_uM 0.26PAX8: PAX8-dependent cytoxicity Measured in Cell-Based System Using Plate Reader - 7054-06_Inhibitor_Dose_CherryPick_Activity [AID687029, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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2
[SID22413484]
Potency 3.1623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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3
[SID22413484]
IC50 3.905High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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4
[SID124384840]
EC50_Mean 4.4SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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5
[SID22413484]
EC50_Mean 6.19Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504549, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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6
[SID117695568]
EC50_Mean 7.17SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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7
[SID124384840]
EC50_Mean 10.9SAR analysis of small molecule agonists of the NTR1 receptor via a luminescent beta-arrestin assay [AID602427, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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8
[SID22413484]
Potency 11.5821qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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9
[SID22413484]
Potency 13.1154Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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10
[SID22413484]
Potency 14.1254qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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11
[SID117695568]
EC50_Mean 14.8SAR analysis of small molecule agonists of the NTR1 receptor via a luminescent beta-arrestin assay [AID602427, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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12
[SID22413484]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID22413484]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID22413484]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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15
[SID22413484]
AC50_uM 18.92HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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16
[SID22413484]
Potency 28.1838qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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17
[SID22413484]
Potency 28.1838qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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18
[SID22413484]
Single concentration confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504550, Type: screening]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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19
[SID22413484]
Image-Based HTS for Selective Agonists for NTR1 [AID493036, Type: screening]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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20
[SID22413484]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a [Homo sapiens] [gi:119579215]
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21
[SID22413484]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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22
[SID22413484]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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23
[SID22413484]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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24
[SID22413484]
uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]G-protein coupled receptor 183 [Homo sapiens] [gi:4826706]
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25
[SID22413484]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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26
[SID22413484]
Leishmania major promastigote HTS [AID1063, Type: screening]
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27
[SID22413484]
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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28
[SID22413484]
Single concentration confirmation of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463218, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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29
[SID22413484]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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30
[SID124384840]
IC50_Mean 20SAR analysis of small molecule agonists of the NTR1 receptor in a dose response fluorescent-based calcium flux assay [AID602459, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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31
[SID22413484]
Potency 25.1189qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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32
[SID22413484]
Potency 28.1838qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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33
[SID22413484]
Potency 35.4813qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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34
[SID117695568]
EC50_Mean 40SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay [AID588495, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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35
[SID124384840]
EC50_Mean 40SAR analysis of small molecule NTR1 agonists in a image based GPR35 selectivity assay [AID588503, Type: confirmatory]G-protein coupled receptor 35 [Homo sapiens] [gi:30526188]
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36
[SID117695568]
EC50_Mean 40SAR analysis of small molecule NTR1 agonists in a image based GPR35 selectivity assay [AID588503, Type: confirmatory]G-protein coupled receptor 35 [Homo sapiens] [gi:30526188]
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37
[SID22413484]
Potency 63.0957qHTS Assay for Inhibitors of the HIV-1 protein Vpr [AID651644, Type: confirmatory]Vpr [Human immunodeficiency virus 1] [gi:28872817]
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38
[SID117695568]
EC50_Mean 80SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay set 2 [AID602334, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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39
[SID124384840]
EC50_Mean 80SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay set 2 [AID602334, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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40
[SID22413484]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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41
[SID22413484]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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42
[SID22413484]
Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. [AID1439, Type: screening]RGS7, partial [Homo sapiens] [gi:1166512]
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43
[SID22413484]
qHTS Assay for Inhibitors of the Six1/Eya2 Interaction [AID651725, Type: screening]six1 [Homo sapiens] [gi:1246761]
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44
[SID22413484]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ MEP2_MLPCN. [AID2016, Type: screening]MEP2 [Saccharomyces cerevisiae] [gi:1302091]
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45
[SID22413484]
Identification and characterization of compounds for addressing human bone marrow failure [AID817, Type: other]unnamed protein product [Saccharomyces cerevisiae] [gi:1360328]
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46
[SID22413484]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W. [AID952, Type: screening]Bcl-w [Homo sapiens] [gi:1572493]
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47
[SID22413484]
uHTS for Calpain Inhibitors [AID1236, Type: screening]calpain II, partial [Sus scrofa] [gi:1628587]
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48
[SID22413484]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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49
[SID22413484]
Potency qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression [AID624202, Type: confirmatory]BRCA1 [Homo sapiens] [gi:1698399]
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50
[SID22413484]
uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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