SMR000229280 (CID 1230852) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(28)
 
 
Inactive(571)
 
 
Inconclusive(22)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srsx(9)
 
 
G-alpha(6)
 
 
 
BioAssay Types:
Screening(416)
 
 
 
 
Confirmatory(188)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(128)
 
 
 
 
 
IC50(35)
 
 
 
 
EC50(18)
 
 
 
AC50(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 618    Data Row: 622   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID22413484]
AC50 0.26PAX8: PAX8-dependent cytoxicity Measured in Cell-Based System Using Plate Reader - 7054-06_Inhibitor_Dose_CherryPick_Activity [AID687029, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
View
2
[SID22413484]
Potency 3.1623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
View
3
[SID22413484]
IC50 3.905High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
View
4
[SID124384840]
EC50 4.4SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
5
[SID124384840]
EC50 4.4SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
6
[SID22413484]
EC50 6.19Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504549, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
7
[SID22413484]
EC50 6.19Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504549, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
8
[SID117695568]
EC50 7.17SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
9
[SID117695568]
EC50 7.17SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
10
[SID124384840]
EC50 10.9SAR analysis of small molecule agonists of the NTR1 receptor via a luminescent beta-arrestin assay [AID602427, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
11
[SID124384840]
EC50 10.9SAR analysis of small molecule agonists of the NTR1 receptor via a luminescent beta-arrestin assay [AID602427, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
12
[SID22413484]
Potency 11.5821qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
View
13
[SID22413484]
Potency 13.1154Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
14
[SID22413484]
Potency 14.1254qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
View
15
[SID117695568]
EC50 14.8SAR analysis of small molecule agonists of the NTR1 receptor via a luminescent beta-arrestin assay [AID602427, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
16
[SID117695568]
EC50 14.8SAR analysis of small molecule agonists of the NTR1 receptor via a luminescent beta-arrestin assay [AID602427, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
17
[SID22413484]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
18
[SID22413484]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
19
[SID22413484]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
20
[SID22413484]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
21
[SID22413484]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
22
[SID22413484]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
23
[SID22413484]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
24
[SID22413484]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
25
[SID22413484]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
26
[SID22413484]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
27
[SID22413484]
AC50 18.92HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
View
28
[SID22413484]
Potency 28.1838qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
View
29
[SID22413484]
Potency 28.1838qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
View
30
[SID22413484]
Potency 28.1838qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
31
[SID22413484]
Potency 28.1838qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
32
[SID22413484]
 uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]GPR183 gene product [Homo sapiens] [gi:4826706]
View
33
[SID22413484]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]CHRM4 gene product [Homo sapiens] [gi:52426748]
View
34
[SID22413484]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]CHRM4 gene product [Homo sapiens] [gi:52426748]
View
35
[SID22413484]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]CHRM4 gene product [Homo sapiens] [gi:52426748]
View
36
[SID22413484]
 Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
View
37
[SID22413484]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
View
38
[SID22413484]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
View
39
[SID22413484]
 Leishmania major promastigote HTS [AID1063, Type: screening]
View
40
[SID22413484]
 Single concentration confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504550, Type: screening]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
41
[SID22413484]
 Single concentration confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504550, Type: screening]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
42
[SID22413484]
 HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
View
43
[SID22413484]
 Image-Based HTS for Selective Agonists for NTR1 [AID493036, Type: screening]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
44
[SID22413484]
 Image-Based HTS for Selective Agonists for NTR1 [AID493036, Type: screening]NTSR1 gene product [Homo sapiens] [gi:110611243]
View
45
[SID22413484]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, i [gi:119579215]
View
46
[SID22413484]
 uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
View
47
[SID22413484]
 Single concentration confirmation of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463218, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
View
48
[SID22413484]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
49
[SID22413484]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
50
[SID124384840]
IC50 20SAR analysis of small molecule agonists of the NTR1 receptor in a dose response fluorescent-based calcium flux assay [AID602459, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
View