phytosphingosine (CID 122121) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(23)
 
 
Inconclusive(2)
 
 
Unspecified(10)
 
 
Top Targets:
RIP(2)
 
 
HELICc(2)
 
 
Menin(2)
 
 
NR LBD ROR li..(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Confirmatory(21)
 
 
 
Literature(17)
 
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(21)
 
 
 
IC50(4)
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 41    Data Row: 41   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103538185]
IC50 3.75Inhibition of wild type human Jurkat cells after 18 hrs by MTT assay [AID357402, Type: Literature]
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2
[SID103538185]
IC50 4.12Inhibition of human 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR3 mutant cells proliferation after 18 hrs by MTT assay [AID357394, Type: Literature]
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3
[SID103538185]
IC50 5.29Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR2 mutant cells proliferation after 18 hrs by MTT assay [AID357393, Type: Literature]
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4
[SID103538185]
IC50 6.57Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR1 mutant cells proliferation after 18 hrs by MTT assay [AID357392, Type: Literature]
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5
[SID103538185]
 Cytotoxicity against human Jurkat cells at 10 uM after 30 mins [AID302642, Type: Literature]
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6
[SID103538185]
 Induction of endogenous ROS accumulation in Candida albicans CAI4 after 3 hrs by 2',7'-dichlorofluorescein diacetate staining [AID407131, Type: Literature]
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7
[SID103538185]
Ki 850Inhibition of Rhodococcus sp. M777 Endoglycoceramidase 2 containing wild type sequence E351S [AID499032, Type: Literature]
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8
[SID103538185]
 Ratio of Kcat to Km of Activity of Rhodococcus sp. M777 Endoglycoceramidase 2 V101M K200R mutant [AID499029, Type: Literature]
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9
[SID103538185]
 Ratio of Kcat to Km of Activity of Rhodococcus sp. M777 Endoglycoceramidase 2 K129N mutant [AID499030, Type: Literature]
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10
[SID103538185]
 Ratio of Kcat to Km of Activity of Rhodococcus sp. M777 Endoglycoceramidase 2 N148S mutant [AID499031, Type: Literature]
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11
[SID103538185]
 Resistance index, ratio of IC50 for 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR1 mutant cells to IC50 for human wild type Jurkat cells [AID357403, Type: Literature]
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12
[SID103538185]
 Resistance index, ratio of IC50 for 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR2 mutant cells to IC50 for human wild type Jurkat cells [AID357404, Type: Literature]
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13
[SID103538185]
 Resistance index, ratio of IC50 for 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR3 mutant cells to IC50 for human wild type Jurkat cells [AID357405, Type: Literature]
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14
[SID103538185]
 Fungicidal activity against Candida glabrata BG2 [AID407127, Type: Literature]
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15
[SID103538185]
 Fungicidal activity against Candida albicans CAI4 [AID407128, Type: Literature]
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16
[SID103538185]
 Fungicidal activity against Candida albicans CAI4 in presence of 10 mM ascorbic acid [AID407129, Type: Literature]
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17
[SID26756990]
Potency 79.4328Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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18
[SID26756990]
Potency 79.4328Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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19
[SID26756990]
Potency 79.4328Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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20
[SID26756990]
Potency 79.4328Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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21
[SID26756990]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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22
[SID26756990]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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23
[SID103538185]
 Cytotoxicity against gamma irradiated human Jurkat cells at 10 uM after 30 mins relative to control [AID302643, Type: Literature]
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24
[SID26756990]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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25
[SID26756990]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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26
[SID26756990]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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27
[SID26756990]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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28
[SID26756990]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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29
[SID26756990]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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30
[SID26756990]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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31
[SID26756990]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
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32
[SID26756990]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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33
[SID26756990]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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34
[SID26756990]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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35
[SID26756990]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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36
[SID26756990]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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37
[SID26756990]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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38
[SID26756990]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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39
[SID26756990]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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40
[SID26756990]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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41
[SID26756990]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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42
[SID26756990]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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43
[SID26756990]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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44
[SID26756990]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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45
[SID26756990]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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46
[SID26756990]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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47
[SID26756990]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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48
[SID26756990]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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49
[SID26756990]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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50
[SID26756990]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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