Bookmark and Share
Acetylcysteine (CID 12035) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(25)
 
 
Inactive(1212)
 
 
Inconclusive(68)
 
 
Unspecified(79)
 
 
Top Targets:
7TM GPCR Srx(32)
 
 
 
NR LBD PPAR(27)
 
 
 
7TM GPCR Srsx(25)
 
 
NR LBD ER(20)
 
 
 
NR LBD AR(16)
 
 
BioAssay Types:
Confirmatory(582)
 
 
 
 
 
Screening(538)
 
 
 
Literature(176)
 
 
 
 
 
Summary(49)
 
 
 
BioActivity Types:
Potency(550)
 
 
 
 
 
IC50(44)
 
 
 
 
EC50(10)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1056    Data Row: 1384   Total Pages: 28   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56423146]
Potency 10qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
View
2
[SID855714]
Potency 25.1189qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
View
3
[SID103182957]
IC50 31Inhibition of horseradish peroxidase [AID295045, Type: Literature]
View
4
[SID855714]
Potency 35.4813qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
View
5
[SID144208276]
Potency-Replicate_1 61.0063qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
6
[SID144208276]
Potency-Replicate_1 61.0063qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
View
7
[SID103182957]
Neuroprotective activity in H2O2-stimulated human SH-SY5Y cells assessed as downregulation of Bcl2 expression at 5 mM incubated for 4 hrs prior to H2O2 challenge measured after 12 hrs by Western blotting analysis [AID737020, Type: Literature]
View
8
[SID103182957]
Inhibition of H2O2-induced cytotoxicity in HUVEC cells assessed as cell viability at 5 mmol/L incubated 4 hrs prior to H2O2 challenge measured after 12 hrs by MTT assay [AID715275, Type: Literature]
View
9
[SID103182957]
Inhibition of H2O2-induced cytotoxicity in HUVEC cells assessed as LDH release at 5 mmol/L incubated 4 hrs prior to H2O2 challenge measured after 12 hrs by LDH assay [AID715276, Type: Literature]
View
10
[SID103182957]
Antioxidant activity against H2O2-induced lipid accumulation in HUVEC cells assessed as reduction in MDA level at 5 mmol/L incubated 4 hrs prior to H2O2 challenge measured after 12 hrs [AID715277, Type: Literature]
View
11
[SID103182957]
Antioxidant activity in HUVEC cells assessed as reduction in H2O2-induced GSH activity at 5 mmol/L incubated 4 hrs prior to H2O2 challenge measured after 12 hrs [AID715278, Type: Literature]
View
12
[SID103182957]
Neuroprotective activity in H2O2-stimulated human SH-SY5Y cells assessed as upregulation of Bax expression at 5 mM incubated for 4 hrs prior to H2O2 challenge measured after 12 hrs by Western blotting analysis [AID737019, Type: Literature]
View
13
[SID103182957]
Potentiation of Angeli's salt induced- vasodilatory activity in Sprague-Dawley rat thoracic aorta at 1 mM [AID577800, Type: Literature]
View
14
[SID103182957]
Potentiation of 1-Nitrosocyclohexyl trifluoroacetate induced- vasodilatory activity in Sprague-Dawley rat thoracic aorta at 1 mM [AID577801, Type: Literature]
View
15
[SID103182957]
FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase [AID588217, Type: Literature]
View
16
[SID103182957]
Increase of lipid peroxidation in gastrocnemius muscle of C57BL/6 mouse tail suspension model assessed as decrease of thiobarbituric acid-reactive substance level at 2.5 pmol administered in gastrocnemius muscle qd for 10 days by RT-PCR analysis [AID527151, Type: Literature]
View
17
[SID103182957]
Inhibition of NO production in BAEC assessed as inhibition of Ca2+ influx at 10 mM [AID513610, Type: Literature]
View
18
[SID103182957]
Reduction of gastrocnemius muscle weight loss in C57BL/6 mouse tail suspension model at 2.5 pmol administered in gastrocnemius muscle qd for 10 days relative to whole body weight [AID527148, Type: Literature]
View
19
[SID48415510]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
View
20
[SID103182957]
Inhibition of 6-hydroxydopamine induced cytotoxicity in rat PC12 cells pretreated for 24 hrs assessed as elevation of intracellular glutathione level [AID360670, Type: Literature]
View
21
[SID103182957]
Inhibition of hydrogen peroxide induced cytotoxicity in rat PC12 cells pretreated for 24 hrs assessed as elevation of intracellular glutathione level [AID360671, Type: Literature]
View
22
[SID103182957]
Antimicrobial activity against catheter-associated biofilm of methicillin-resistant Staphylococcus aureus [AID285163, Type: Literature]
View
23
[SID103182957]
Antimicrobial activity against catheter-associated biofilm of methicillin-resistant Staphylococcus epidermidis [AID285164, Type: Literature]
View
24
[SID103182957]
Antimicrobial activity against catheter-associated biofilm of Klebsiella pneumoniae [AID285165, Type: Literature]
View
25
[SID56423146]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
View
26
[SID103182957]
Ki 2000TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes [AID680341, Type: other]Solute carrier family 22 member 6 [gi:81886651]
View
27
[SID103182957]
IC50 28800Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay [AID695876, Type: Literature]
View
28
[SID103182957]
IC50 29900Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay [AID695877, Type: Literature]
View
29
[SID103182957]
Prevention of apoptosis in rat H9c2 cells assessed as protection against oxidative stress-induced cytotoxicity at 100 nM pM by Alamar blue assay [AID710226, Type: Literature]
View
30
[SID103182957]
Prevention of apoptosis in rat H9c2 cells assessed as reduction in fall of mitochondrial membrane potential at 100 nM after 1 hr [AID710227, Type: Literature]
View
31
[SID103182957]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
View
32
[SID103182957]
FDA HLAED, lactate dehydrogenase (LDH) increase [AID588218, Type: Literature]
View
33
[SID103182957]
FDA HLAED, gamma-glutamyl transferase (GGT) increase [AID588219, Type: Literature]
View
34
[SID103182957]
Decrease in ROS generation in human NTUB1 cells at 1 mM after 24 hrs by H2DCFDA staining based flow cytometeric analysis relative to control [AID608130, Type: Literature]
View
35
[SID103182957]
Cell cycle arrest in human NTUB1 cells assessed as accumulation at subG1 phase at 1mM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 6.68%) [AID608192, Type: Literature]
View
36
[SID103182957]
Cell cycle arrest in human NTUB1 cells assessed as accumulation at G1 phase at 1 mM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 50.64%) [AID608193, Type: Literature]
View
37
[SID103182957]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
View
38
[SID103182957]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
View
39
[SID103182957]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
View
40
[SID103182957]
FDA HLAED, liver enzyme composite activity [AID588214, Type: Literature]
View
41
[SID103182957]
FDA HLAED, alkaline phosphatase increase [AID588215, Type: Literature]
View
42
[SID103182957]
FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase [AID588216, Type: Literature]
View
43
[SID103182957]
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
View
44
[SID103182957]
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
View
45
[SID103182957]
Neuroprotective activity against rotenone/oligomycin-A-induced death in human SH-SY5Y cells assessed as increase of cell viability at 1 mM after 2 hrs by MTT assay [AID551412, Type: Literature]
View
46
[SID103182957]
Neuroprotective activity against rotenone/oligomycin-A-induced death in human SH-SY5Y cells assessed as protective effect at 1 mM after 2 hrs by MTT assay [AID551415, Type: Literature]
View
47
[SID103182957]
Neuroprotection against rotenone/oligomycin-A-indced human SH-SY5Y cell death assessed as protective effect at 1 uM after 2 hrs by MTT assay [AID552793, Type: Literature]
View
48
[SID103182957]
Inhibition of amphotericin B-induced renal tubular apoptosis in Sprague-Dawley rat assessed as apoptotic index at 30 mg/kg, ip BID measured post last dose [AID561438, Type: Literature]
View
49
[SID103182957]
Inhibition of amphotericin B-induced renal tubular apoptosis in Sprague-Dawley rat assessed as apoptotic index at 60 mg/kg, ip BID measured post last dose [AID561439, Type: Literature]
View
50
[SID103182957]
Inhibition of amphotericin B-induced renal tubular apoptosis in Sprague-Dawley rat assessed as apoptotic index at 120 mg/kg, ip BID measured post last dose [AID561440, Type: Literature]
View