Acetylcysteine (CID 12035) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(17)
 
 
Inactive(946)
 
 
Inconclusive(40)
 
 
Unspecified(73)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
 
alkPPc(14)
 
 
Tryp SPc(12)
 
 
7TM GPCR Srsx(12)
 
 
NR LBD PPAR(11)
 
 
 
BioAssay Types:
Screening(476)
 
 
 
Confirmatory(402)
 
 
 
 
 
Literature(161)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(342)
 
 
 
 
 
IC50(37)
 
 
 
EC50(10)
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 907    Data Row: 1076   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56423146]
Potency 10qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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2
[SID855714]
Potency 25.1189qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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3
[SID103182957]
IC50 31Inhibition of horseradish peroxidase [AID295045, Type: Literature]
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4
[SID855714]
Potency 35.4813qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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5
[SID103182957]
 Potentiation of Angeli's salt induced- vasodilatory activity in Sprague-Dawley rat thoracic aorta at 1 mM [AID577800, Type: Literature]
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6
[SID103182957]
 Potentiation of 1-Nitrosocyclohexyl trifluoroacetate induced- vasodilatory activity in Sprague-Dawley rat thoracic aorta at 1 mM [AID577801, Type: Literature]
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7
[SID103182957]
 Inhibition of NO production in BAEC assessed as inhibition of Ca2+ influx at 10 mM [AID513610, Type: Literature]
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8
[SID103182957]
 Inhibition of 6-hydroxydopamine induced cytotoxicity in rat PC12 cells pretreated for 24 hrs assessed as elevation of intracellular glutathione level [AID360670, Type: Literature]
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9
[SID103182957]
 Inhibition of hydrogen peroxide induced cytotoxicity in rat PC12 cells pretreated for 24 hrs assessed as elevation of intracellular glutathione level [AID360671, Type: Literature]
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10
[SID56423146]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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11
[SID48415510]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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12
[SID103182957]
 Antimicrobial activity against catheter-associated biofilm of methicillin-resistant Staphylococcus aureus [AID285163, Type: Literature]
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13
[SID103182957]
 Antimicrobial activity against catheter-associated biofilm of methicillin-resistant Staphylococcus epidermidis [AID285164, Type: Literature]
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14
[SID103182957]
 Antimicrobial activity against catheter-associated biofilm of Klebsiella pneumoniae [AID285165, Type: Literature]
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15
[SID103182957]
 Reduction of gastrocnemius muscle weight loss in C57BL/6 mouse tail suspension model at 2.5 pmol administered in gastrocnemius muscle qd for 10 days relative to whole body weight [AID527148, Type: Literature]
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16
[SID103182957]
 Increase of lipid peroxidation in gastrocnemius muscle of C57BL/6 mouse tail suspension model assessed as decrease of thiobarbituric acid-reactive substance level at 2.5 pmol administered in gastrocnemius muscle qd for 10 days by RT-PCR analysis [AID527151, Type: Literature]
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17
[SID103182957]
 FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase [AID588217, Type: Literature]
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18
[SID103182957]
Ki 2000TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes [AID680341, Type: other]Solute carrier family 22 member 6 [gi:81886651]
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19
[SID103182957]
 Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy [AID386623, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
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20
[SID103182957]
 TP_TRANSPORTER: inhibition of DNP-NAC uptake (DNP-NAC: 1 uM, NAC: 1000 uM) in Xenopus laevis oocytes [AID681809, Type: other]Solute carrier family 22 member 6 [gi:81886651]
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21
[SID56423146]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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22
[SID56423146]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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23
[SID103182957]
 FDA HLAED, lactate dehydrogenase (LDH) increase [AID588218, Type: Literature]
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24
[SID103182957]
 FDA HLAED, gamma-glutamyl transferase (GGT) increase [AID588219, Type: Literature]
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25
[SID103182957]
 Decrease in ROS generation in human NTUB1 cells at 1 mM after 24 hrs by H2DCFDA staining based flow cytometeric analysis relative to control [AID608130, Type: Literature]
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26
[SID103182957]
 Cell cycle arrest in human NTUB1 cells assessed as accumulation at subG1 phase at 1mM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 6.68%) [AID608192, Type: Literature]
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27
[SID103182957]
 Cell cycle arrest in human NTUB1 cells assessed as accumulation at G1 phase at 1 mM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 50.64%) [AID608193, Type: Literature]
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28
[SID103182957]
 Cell cycle arrest in human NTUB1 cells assessed as accumulation at S phase at 1 mM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 20.37%) [AID608194, Type: Literature]
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29
[SID103182957]
 Cell cycle arrest in human NTUB1 cells assessed as accumulation at G2/M phase at 1 mM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 20.37%) [AID608195, Type: Literature]
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30
[SID103182957]
 Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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31
[SID103182957]
 Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
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32
[SID103182957]
 Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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33
[SID103182957]
 Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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34
[SID103182957]
 Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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35
[SID103182957]
 FDA HLAED, liver enzyme composite activity [AID588214, Type: Literature]
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36
[SID103182957]
 FDA HLAED, alkaline phosphatase increase [AID588215, Type: Literature]
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37
[SID103182957]
 FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase [AID588216, Type: Literature]
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38
[SID103182957]
 Cytotoxicity against human NTUB1 cells assessed as cell viability at 1 mM after 72 hrs by MTT assay relative to control [AID616405, Type: Literature]
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39
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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40
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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41
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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42
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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43
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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44
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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45
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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46
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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47
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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48
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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49
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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50
[SID103182957]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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