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[(5Z)-5-(2,6-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid (CID 1201205) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(11)
 
 
Top Targets:
Lactamase B(5)
 
 
 
DSPc(2)
 
 
PTPc(1)
 
 
RNase H(1)
 
 
NR LBD NGFI-B(1)
 
 
BioAssay Types:
Screening(4)
 
 
Confirmatory(3)
 
 
BioActivity Types:
IC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 12    Data Row: 12   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124384966]
MIC [4 fold reduction] 3.125Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective): VIM-2-transformed E. coli growth inhibition in the presence of imipenem (synergy) [AID624081, Type: other]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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2
[SID124384966]
MIC [4 fold reduction] 12.5Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective): Growth inhibition of clinically relevant VIM-2-transformed Acinetobacter species (YMC07/8/B3323) in the presence of imipenem (synergy) [AID624096, Type: other]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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3
[SID124384966]
MIC [4 fold reduction] 100Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective): Growth inhibition of clinically relevant IMP-1 transformed P. aeruginosa (KN20) in the presence of imipenem (synergy) [AID624095, Type: other]metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa] [gi:27368096]
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4
[SID124384966]
MIC [4 fold reduction] 100Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective): Growth inhibition of clinically relevant VIM-2 transformed P. aeruginosa (PA641) in the presence of imipenem (synergy) [AID624080, Type: other]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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5
[SID124384966]
MIC [4 fold reduction] 100Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective): Growth inhibition of clinically relevant New Delhi metallo-beta-lactamase-1 (NDM-1)-transformed K. pneumoniae (BAA-2146) in the presence of imipenem (synergy) [AID624082, Type: other]NDM-1 metallo-beta-lactamase [Escherichia coli] [gi:345105285]
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6
[SID17449765]
High Throughput Screen for Inhibitors of ER Stress-induced Cell Death [AID1010, Type: screening]
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7
[SID17449765]
HTS Colorimetric assay for the identification of compounds that inhibit VHR1 [AID1992, Type: screening]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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8
[SID17449765]
Fluorescence Polarization Screen Assay for Bcl-B Phenotype Converters [AID1240, Type: screening]nuclear receptor subfamily 4 group A member 1 isoform 1 [Homo sapiens] [gi:27894344]
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9
[SID8079527]
HIV-1 RNase H Inhibition [AID372, Type: screening]Chain A, Solution Structure Of The Rnase H Domain Of The Hiv-1 Reverse Transcriptase In The Presence Of Magnesium [gi:28949057]
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10
[SID17449765]
IC50 High Throughput Screening Assay for Hsp70 Inhibitors [AID583, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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11
[SID17449765]
IC50 MKP-3 in vitro HTS assay [AID425, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
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12
[SID17449765]
IC50 HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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