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1-(1-acetyl-piperidine-4-yl)-3-adamantan-1-yl-urea (CID 12000797) - Compound BioActivity Data
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BioActivity Outcomes:
Active(15)
 
 
Inactive(6)
 
 
Unspecified(18)
 
 
Top Targets:
HAD like(8)
 
 
CAP ED(1)
 
 
BioAssay Types:
Literature(39)
 
 
 
 
BioActivity Types:
IC50(12)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 39    Data Row: 39   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103499776]
IC50 0.002Inhibition of hamster soluble epoxide hydrolase by radioactive assay [AID296660, Type: Literature]
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2
[SID103499776]
IC50 0.003Inhibition of mouse soluble epoxide hydrolase [AID568457, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:1708375]
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3
[SID103499776]
IC50 0.006Inhibition of rat recombinant soluble epoxide hydrolase by fluorescent assay [AID296659, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:462371]
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4
[SID103499776]
IC50 0.007Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay [AID270314, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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5
[SID103499776]
IC50 0.007Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay [AID638441, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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6
[SID103499776]
IC50 0.008Inhibition of human soluble epoxide hydrolase [AID568456, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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7
[SID103499776]
IC50 0.009Inhibition of mouse recombinant soluble epoxide hydrolase by fluorescent assay [AID296658, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:1708375]
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8
[SID103499776]
IC50 0.015Inhibition of human sEH by fluorescent assay [AID296663, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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9
[SID103499776]
IC50 0.057Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET [AID568458, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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10
[SID103499776]
IC50 0.057Inhibition of human sEH by cell based assay [AID676945, Type: Literature]
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11
[SID103499776]
IC50 0.45Inhibition of cat soluble epoxide hydrolase by radioactive assay [AID296661, Type: Literature]
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12
[SID103499776]
IC50 0.5Inhibition of dog soluble epoxide hydrolase by radioactive assay [AID296662, Type: Literature]
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13
[SID103499776]
Inhibition of soluble epoxide hydrolase in diet induced obese mouse assessed as inhibition of EET hydrolysis at 100 mg/kg, po BID for 4 weeks measured 7 hrs post last dose [AID568473, Type: Literature]
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14
[SID103499776]
Antihypertensive activity against AngII-induced hypertension in telemetered rat assessed as decrease in diastolic blood pressure at 50 mg/kg, po [AID568475, Type: Literature]
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15
[SID103499776]
Antidiabetic activity in diet induced obese mouse assessed as reduction in maximal glucose excursion at 100 mg/kg, po BID for 4 weeks [AID568471, Type: Literature]
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16
[SID103499776]
Inhibition of soluble epoxide hydrolase in diet induced obese mouse assessed as inhibition of EET hydrolysis at 100 mg/kg, po BID for 4 weeks measured 12 hrs post last dose [AID568472, Type: Literature]
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17
[SID103499776]
AUC in dog at 0.3 mg/kg, po [AID270315, Type: Literature]
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18
[SID103499776]
Membrane permeability across human Caco2 monolayer [AID568466, Type: Literature]
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19
[SID103499776]
Inhibition of human ERG by patch clamp analysis [AID568459, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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20
[SID103499776]
Inhibition of sEH activity in human at 100 to 400 mg administered every 8 hrs [AID676943, Type: Literature]
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21
[SID103499776]
Antihypertensive activity against AngII-induced hypertension in telemetered rat assessed as decrease in systolic blood pressure at 50 mg/kg, po [AID568474, Type: Literature]
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22
[SID103499776]
Oral bioavailability in rat [AID676955, Type: Literature]
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23
[SID103499776]
Oral bioavailability in cynomolgus monkey [AID568467, Type: Literature]
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24
[SID103499776]
Oral bioavailability in rat [AID568468, Type: Literature]
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25
[SID103499776]
Antihypertensive activity against spontaneously hypertensive rat assessed as decrease in mean blood pressure at 300 mg/kg, po [AID568469, Type: Literature]
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26
[SID103499776]
AUC in in dog at 0.3 mg/kg, po [AID296664, Type: Literature]
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27
[SID103499776]
AUC (24 hrs) in rat at 10 mg/kg, po [AID568460, Type: Literature]
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28
[SID103499776]
Oral bioavailability in cynomolgus monkey [AID676956, Type: Literature]
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29
[SID103499776]
Antidiabetic activity in DIO mouse assessed as inhibition of blood sEH activity at 100 mg/kg, po bid up to 7 hrs [AID676957, Type: Literature]
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30
[SID103499776]
Antidiabetic activity in DIO mouse assessed as inhibition of blood sEH activity at 100 mg/kg, po bid after 12 hrs [AID676958, Type: Literature]
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31
[SID103499776]
Terminal half life in human [AID676959, Type: Literature]
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32
[SID103499776]
Inhibition of sEH activity in human at 250 mg after 8 hrs [AID676960, Type: Literature]
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33
[SID103499776]
Inhibition of sEH activity in human at 500 mg after 12 hrs [AID676961, Type: Literature]
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34
[SID103499776]
Antihypertensive activity against spontaneously hypertensive rat assessed as decrease in mean blood pressure at 100 mg/kg, po [AID568470, Type: Literature]
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35
[SID103499776]
Inhibition of CYP1A2 [AID568461, Type: Literature]
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36
[SID103499776]
Inhibition of CYP2B6 [AID568462, Type: Literature]
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37
[SID103499776]
Inhibition of CYP2C9 [AID568463, Type: Literature]
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38
[SID103499776]
Inhibition of CYP2C19 [AID568464, Type: Literature]
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39
[SID103499776]
Inhibition of CYP3A4 [AID568465, Type: Literature]
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