valdecoxib (CID 119607) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(84)
 
 
Inactive(709)
 
 
Inconclusive(12)
 
 
Unspecified(201)
 
 
Top Targets:
alpha CA I II..(32)
 
 
 
7TM GPCR Srx(31)
 
 
 
7TM GPCR Srsx(18)
 
 
 
prostaglandin..(17)
 
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Screening(395)
 
 
 
 
Confirmatory(242)
 
 
 
 
Literature(216)
 
 
 
 
 
BioActivity Types:
IC50(183)
 
 
 
 
Potency(182)
 
 
 
 
Ki(68)
 
 
 
 
EC50(16)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 895    Data Row: 1006   Total Pages: 21   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103225393]
IC50 0.005Compound was tested for its inhibitory activity against recombinant human Prostaglandin G/H synthase 2 [AID162347, Type: other]
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2
[SID103225393]
IC50 0.005In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 2 [AID162482, Type: other]
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3
[SID103225393]
IC50 0.005Inhibitory activity against human recombinant cyclooxygenase 2 [AID254750, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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4
[SID103225393]
IC50 0.00501Inhibition of human Prostaglandin G/H synthase 2 [AID160434, Type: Literature]
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5
[SID103225393]
Ki 0.013Inhibitory activity against cloned human CA12 [AID258733, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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6
[SID103225393]
Ki 0.013Inhibition of human carbonic anhydrase 12-catalyzed CO2 hydration activity by stopped flow assay [AID620688, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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7
[SID103225393]
Ki 0.019Inhibition of Brucella suis carbonic anhydrase I by spectrophotometry at pH 8.3 [AID577531, Type: Literature]
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8
[SID103225393]
IC50 0.027Inhibitory activity against human carbonic anhydrase IX was determined [AID48294, Type: Literature]
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9
[SID103225393]
Ki 0.027Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method [AID48303, Type: Literature]
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10
[SID103225393]
Ki 0.027Inhibition of human carbonic anhydrase 9-catalyzed CO2 hydration activity by stopped flow assay [AID620687, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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11
[SID103225393]
Ki 0.027Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay [AID369274, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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12
[SID103225393]
Ki 0.027Inhibitory activity against cloned human CA9 [AID258732, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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13
[SID103225393]
Ki 0.0287Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay [AID552130, Type: Literature]
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14
[SID103225393]
Ki 0.0287Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay [AID436565, Type: Literature]
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15
[SID103225393]
IC50 0.04Inhibition of human recombinant COX2 [AID312221, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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16
[SID103225393]
Ki 0.043Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay [AID427124, Type: Literature]
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17
[SID103225393]
IC50 0.043Inhibitory activity of compound against human carbonic anhydrase II [AID47748, Type: Literature]
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18
[SID103225393]
IC50 0.043Inhibitory activity against human carbonic anhydrase II was determined [AID47749, Type: Literature]
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19
[SID103225393]
Ki 0.043Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method [AID48090, Type: Literature]
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20
[SID103225393]
Ki 0.043Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method [AID669115, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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21
[SID103225393]
Ki 0.043Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay [AID552128, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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22
[SID103225393]
Ki 0.043Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 [AID577527, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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23
[SID103225393]
Ki 0.043Inhibitory activity against human carbonic anhydrase II (hCAII) [AID238574, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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24
[SID103225393]
Ki 0.043Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration activity by stopped flow assay [AID620686, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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25
[SID103225393]
Ki 0.043Inhibitory activity against cloned human CA2 [AID258730, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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26
[SID103225393]
Ki 0.043Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay [AID349606, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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27
[SID103225393]
Ki 0.043Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay [AID367821, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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28
[SID103225393]
Ki 0.043Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay [AID369272, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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29
[SID103225393]
Ki 0.043Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method [AID414956, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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30
[SID103225393]
Ki 0.043Inhibition of human recombinant CA2 by stopped-flow CO2 assay [AID436564, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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31
[SID103225393]
Ki 0.043Inhibition of human recombinant CA2 by stopped-flow hydration assay [AID437749, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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32
[SID103225393]
Ki 0.043Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay [AID644381, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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33
[SID103225393]
Ki 0.066Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay [AID369275, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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34
[SID103225393]
Ki 0.13Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila [AID239146, Type: Literature]Carbonic anhydrase [gi:729004]
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35
[SID103225393]
IC50 0.183Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 hr before arachidonic acid challenge by enzyme immunoassay [AID432545, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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36
[SID103225393]
IC50 0.183Inhibition of human cyclooxygenase-2 expressed in COS cells [AID241308, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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37
[SID103225393]
IC50 0.208DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) [AID625244, Type: other]Prostaglandin G/H synthase 2 [gi:3915797]
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38
[SID103225393]
Ki 0.24Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila [AID239145, Type: Literature]Carbonic anhydrase [gi:729004]
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39
[SID103225393]
IC50 0.34Inhibitory activity of compound against bovine carbonic anhydrase IV [AID48112, Type: Literature]
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40
[SID103225393]
IC50 0.34Inhibitory activity against bovine carbonic anhydrase IV was determined [AID48114, Type: Literature]
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41
[SID103225393]
Ki 0.34Inhibitory activity against bovine carbonic anhydrase IV (bCAIV) [AID238597, Type: Literature]
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42
[SID103225393]
Ki 0.34Inhibitory activity against CA4 isolated from bovine lung microsomes [AID258731, Type: Literature]Carbonic anhydrase 4 [gi:5915863]
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43
[SID103225393]
Ki 0.425Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method [AID48310, Type: Literature]
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44
[SID103225393]
Ki 0.517Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay [AID644379, Type: Literature]
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45
[SID103225393]
IC50 0.57In vitro inhibitory concentration against Prostaglandin G/H synthase 2 in human whole blood assay [AID242103, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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46
[SID103225393]
Ki 0.572Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay [AID369273, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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47
[SID103225393]
Ki 0.612Inhibition of Brucella suis carbonic anhydrase II by spectrophotometry at pH 8.3 [AID577530, Type: Literature]
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48
[SID103225393]
Ki 0.654Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay [AID367822, Type: Literature]Carbonic anhydrase [gi:1709238]
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49
[SID103225393]
IC50 0.66Inhibition of COX2 in human whole blood assessed as effect on thrombin-induced TXB2 production [AID340785, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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50
[SID103225393]
Ki 0.682Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay [AID437750, Type: Literature]Carbonic anhydrase 2 [gi:81669460]
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