SMR000161891 (CID 11958779) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(89)
 
 
Inactive(532)
 
 
Inconclusive(31)
 
 
Unspecified(3)
 
 
Top Targets:
alkPPc(20)
 
 
 
7TM GPCR Srx(19)
 
 
Bcl-2 like(12)
 
 
 
G-alpha(11)
 
 
 
 
p450(9)
 
 
 
 
BioAssay Types:
Screening(420)
 
 
 
 
 
Confirmatory(210)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(138)
 
 
 
 
 
IC50(46)
 
 
 
 
EC50(19)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 650    Data Row: 655   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17409262]
Potency 0.2668qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
View
2
[SID17409262]
Potency 0.2818qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
View
3
[SID17409262]
Potency 0.2818qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
View
4
[SID17409262]
Potency 0.2906qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]
View
5
[SID17409262]
Potency 0.7079qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
View
6
[SID17409262]
Potency 0.7079qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
View
7
[SID17409262]
Potency 1qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
View
8
[SID17409262]
IC50 1.0702High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
View
9
[SID17409262]
IC50 1.0702High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
View
10
[SID17409262]
IC50 1.0702High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
View
11
[SID17409262]
IC50 1.501QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2195, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
View
12
[SID17409262]
IC50 1.501QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2195, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
View
13
[SID17409262]
Potency 1.5849qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
View
14
[SID17409262]
Potency 1.5849qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
View
15
[SID17409262]
Potency 1.5849qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
View
16
[SID17409262]
Potency 1.5849qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
View
17
[SID17409262]
Potency 1.9953qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
View
18
[SID17409262]
Potency 1.9953Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2572, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
View
19
[SID17409262]
Potency 2.2387Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
View
20
[SID17409262]
Potency 2.2387qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
View
21
[SID17409262]
Potency 2.2387qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase [AID602233, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
View
22
[SID17409262]
EC50 2.28Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. [AID1871, Type: confirmatory]RGS7 [Homo sapiens] [gi:1166512]
View
23
[SID17409262]
Potency 2.8184qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
View
24
[SID17409262]
Potency 3.1381qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
View
25
[SID17409262]
Potency 3.1381qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
View
26
[SID17409262]
Potency 3.1381qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
View
27
[SID17409262]
EC50 3.8Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1872, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301151]
View
28
[SID17409262]
EC50 3.8Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1872, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301151]
View
29
[SID17409262]
EC50 3.8Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1872, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301151]
View
30
[SID17409262]
EC50 3.99Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao. [AID1888, Type: confirmatory]regulator of G-protein signaling 16 [Homo sapiens] [gi:156416009]
View
31
[SID17409262]
EC50 4.25Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS19-Galphao. [AID1884, Type: confirmatory]regulator of G-protein signaling 19 [Homo sapiens] [gi:86990435]
View
32
[SID92117384]
IC50 6Late stage assay provider results from the probe development effort to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (M18AAP): radiolabel-based cell-based dose response assay to identify compounds that inhibit P. falciparum growth in RBCs [AID489011, Type: confirmatory]
View
33
[SID17409262]
Potency 6.3096Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Assay [AID2564, Type: confirmatory]
View
34
[SID17409262]
Potency 6.3096Counterscreen for APE1 Inhibitors: Confirmatory Fluorescent Dye Displacement Assay [AID2741, Type: confirmatory]
View
35
[SID17409262]
Potency 6.7456qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
36
[SID17409262]
Potency 7.9433HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
View
37
[SID17409262]
Potency 12.5893qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
View
38
[SID17409262]
Potency 12.5893qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
39
[SID17409262]
Potency 12.5893qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
40
[SID17409262]
IC50 12.8Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay [AID488785, Type: confirmatory]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
View
41
[SID17409262]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
View
42
[SID17409262]
IC50 21.11Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]RACGAP1 gene product [Homo sapiens] [gi:21361397]
View
43
[SID17409262]
IC50 28.77Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Counter Screen Coupled Enzyme [AID624351, Type: confirmatory]
View
44
[SID17409262]
Potency 39.8107qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
View
45
[SID17409262]
CC50 100Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - HeLa Cytotoxicity [AID624300, Type: confirmatory]
View
46
[SID17409262]
 Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
View
47
[SID92117384]
 Late stage assay provider results from the probe development effort to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (M18AAP): radiolabel-based cell-based assay to identify compounds that inhibit P. falciparum growth in RBCs [AID489015, Type: other]
View
48
[SID17409262]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]
View
49
[SID17409262]
 uHTS identification of small molecule inhibitors of Artemis endonuclease activity via a fluorescence intensity assay [AID686954, Type: screening]
View
50
[SID17409262]
 Counterscreen for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl): Fluorescence-based biochemical high throughput assay to identify GFP inhibitors and fluorescence quenchers [AID602125, Type: screening]green fluorescent protein [Aequorea victoria] [gi:634009]
View