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SMR000161891 (CID 11958779) - Compound BioActivity Data
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BioActivity Outcomes:
Active(108)
 
 
Inactive(596)
 
 
Inconclusive(36)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
alkPPc(20)
 
 
 
7TM GPCR Srsx(17)
 
 
G-alpha(14)
 
 
 
 
Bcl-2 like(13)
 
 
 
BioAssay Types:
Screening(468)
 
 
 
 
 
Confirmatory(242)
 
 
 
 
 
Literature(11)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(164)
 
 
 
 
 
IC50(51)
 
 
 
 
EC50(19)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 671    Data Row: 743   Total Pages: 38   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17409262]
Potency 0.121qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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2
[SID17409262]
Potency 0.2668qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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3
[SID17409262]
Potency 0.271qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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4
[SID17409262]
Potency 0.2818qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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5
[SID17409262]
Potency 0.2906qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:115503961]
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6
[SID17409262]
Potency 0.3381qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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7
[SID17409262]
Potency 0.4228qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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8
[SID17409262]
Potency 0.7079qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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9
[SID17409262]
Potency 1qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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10
[SID17409262]
IC50 1.0702High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 isoform 1 [Homo sapiens] [gi:27894344]
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11
[SID17409262]
IC50 1.501QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2195, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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12
[SID17409262]
Potency 1.5849qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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13
[SID17409262]
Potency 1.5849qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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14
[SID17409262]
Potency 1.5849qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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15
[SID17409262]
IC50_Artemis_Mean 1.91Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay [AID720701, Type: confirmatory]protein artemis isoform a [Homo sapiens] [gi:76496497]
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16
[SID17409262]
Potency 1.9953qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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17
[SID17409262]
Potency 1.9953Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2572, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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18
[SID17409262]
Potency 2.2387qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase [AID602233, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:115503961]
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19
[SID17409262]
Potency 2.2387Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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20
[SID17409262]
Potency 2.2387qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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