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MLS000540215 (CID 11958770) - Compound BioActivity Data
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BioActivity Outcomes:
Active(46)
 
 
Inactive(670)
 
 
Inconclusive(25)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(19)
 
 
Bcl-2 like(13)
 
 
 
alkPPc(12)
 
 
TRP 2(10)
 
 
 
BioAssay Types:
Screening(493)
 
 
 
 
 
Confirmatory(226)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(150)
 
 
 
 
 
IC50(51)
 
 
 
 
EC50(17)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 675    Data Row: 743   Total Pages: 38   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17409012]
Potency 3.1623qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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2
[SID17409012]
Potency 9.5283qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID17409012]
Potency 12.5893qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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4
[SID17409012]
IC50 12.8672Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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5
[SID17409012]
IC50_Mean 13.8Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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6
[SID17409012]
Potency 14.581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID17409012]
IC50_Artemis_Mean 16.9Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay [AID720701, Type: confirmatory]protein artemis isoform a [Homo sapiens] [gi:76496497]
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8
[SID17409012]
IC50_Mean 23.4Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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9
[SID17409012]
IC50_Mean 23.4Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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10
[SID17409012]
CC50 25.15Vero Cytoxicity Assay: A Cell Based Secondary Assay to Explore Cytotoxicity of Compounds that Inhibit Flavivirus Genomic Capping Enzyme [AID588742, Type: confirmatory]
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11
[SID17409012]
Potency 28.1838qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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12
[SID17409012]
High Throughput Screening for Cocaine Antagonists: Primary Screen [AID449768, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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13
[SID17409012]
uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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14
[SID17409012]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID757, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
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15
[SID17409012]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant [AID764, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
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16
[SID17409012]
Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_Activity [AID588436, Type: screening]
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17
[SID17409012]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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18
[SID17409012]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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19
[SID17409012]
Screen for Chemicals that Inhibit the RAM Network [AID868, Type: screening]
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20
[SID17409012]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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