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Lopac0_000143 (CID 11957460) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(132)
 
 
Inconclusive(22)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(6)
 
 
Pyr redox dim(5)
 
 
 
HELICc(4)
 
 
PIKKc TOR(4)
 
 
ANK(3)
 
 
 
BioAssay Types:
Confirmatory(137)
 
 
 
 
 
Screening(13)
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(137)
 
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 141    Data Row: 158   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50105877]
Potency 7.9433qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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2
[SID50105877]
Potency 7.9433qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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3
[SID90341745]
Potency 44.6684qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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4
[SID50105877]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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5
[SID90341745]
Potency 0.5012qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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6
[SID50105877]
Potency 0.7943qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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7
[SID50105877]
Potency Validation screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells [AID504364, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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8
[SID90341745]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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9
[SID90341745]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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10
[SID50105877]
Potency HTS Assay for Compounds that Act as Enhancers of the Vanilloid Receptor 1 [AID488979, Type: confirmatory]transient receptor potential cation channel subfamily V member 1 [Homo sapiens] [gi:74315350]
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11
[SID50105877]
Potency Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay [AID1707, Type: confirmatory]
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12
[SID50105877]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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13
[SID90341745]
Potency qHTS Validation Assay to Find Inhibitors of Phosphoglycerate Kinase [AID504547, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:115503961]
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14
[SID90341745]
Potency Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493106, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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15
[SID90341745]
Potency Validation screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493107, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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16
[SID90341745]
Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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17
[SID90341745]
Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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18
[SID50105877]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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19
[SID90341745]
Potency High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity: MmCpn Primary Screen [AID488978, Type: confirmatory]chaperonin GroEL [Methanococcus maripaludis S2] [gi:45359078]
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20
[SID50105877]
Potency qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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