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GR 113808 (CID 119376) - Compound BioActivity Data
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BioActivity Outcomes:
Active(40)
 
 
Inactive(729)
 
 
Inconclusive(37)
 
 
Unspecified(21)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
p450(12)
 
 
 
7TM GPCR Srsx(12)
 
 
TAS2R(8)
 
 
 
 
HELICc(7)
 
 
BioAssay Types:
Screening(369)
 
 
 
Confirmatory(367)
 
 
 
 
 
Literature(67)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(305)
 
 
 
 
 
IC50(23)
 
 
 
 
Ki(17)
 
 
 
AC50(1)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 676    Data Row: 827   Total Pages: 42   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103209519]
Ki 3.98e-05Displacement of [3H]GR113808 from human 5HT4B receptor expressed in HEK293 cells [AID781013, Type: Literature]5-hydroxytryptamine receptor 4 [gi:12644029]
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2
[SID103209519]
Ki 3.98e-05Displacement of [3H]GR113808 from human 5-HT4B receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysis [AID754104, Type: Literature]5-hydroxytryptamine receptor 4 [gi:12644029]
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3
[SID103209519]
Ki 7.41e-05Antagonistic activity at human 5HT4 receptor expressed in HEK293 cells [AID548650, Type: Literature]5-hydroxytryptamine receptor 4 [gi:12644029]
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4
[SID103209519]
Ki 7.8e-05Binding affinity was determined against cloned 5-hydroxytryptamine 4D receptor isoform expressed in COS-7 cells [AID6469, Type: Literature]
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5
[SID103209519]
Ki 0.0001Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]GR-113808 [AID6472, Type: Literature]
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6
[SID103209519]
Ki 0.00011Binding affinity against 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as radioligand [AID6175, Type: Literature]5-hydroxytryptamine receptor 4 [gi:6224984]
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7
[SID103209519]
Ki 0.00015Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand [AID6239, Type: Literature]
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8
[SID103209519]
Ki 0.00015Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]GR-113808 displacement. [AID6246, Type: Literature]
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9
[SID103209519]
Ki 0.000158Binding affinity at 5HT4 receptor [AID416400, Type: Literature]
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10
[SID103209519]
IC50 0.00021Antagonist activity at human 5HT4ER expressed in CHO cells assessed as reduction in cAMP levels [AID707290, Type: Literature]5-hydroxytryptamine receptor 4 [gi:12644029]
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11
[SID103209519]
Ki 0.00033Binding affinity was determined against cloned 5-hydroxytryptamine 4A receptor isoform expressed in COS-7 cells [AID6466, Type: Literature]
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12
[SID103209519]
Ki 0.00041Binding affinity was determined against cloned 5-hydroxytryptamine 4C receptor isoform expressed in COS-7 cells [AID6468, Type: Literature]
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13
[SID103209519]
Ki 0.0005Binding affinity to Rluc fused 5HT4 receptor expressed in CHO cells [AID297386, Type: Literature]5-hydroxytryptamine receptor 4 [gi:12644029]
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14
[SID103209519]
Ki 0.0005Displacement of [3H]GR-113808 from human 5HT4e receptor expressed in C6 cells [AID297383, Type: Literature]
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15
[SID103209519]
Ki 0.00053Binding affinity was determined against cloned 5-hydroxytryptamine 4B receptor isoform expressed in COS-7 cells [AID6467, Type: Literature]
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16
[SID103209519]
Ki 0.0007Binding affinity to YFP fused 5HT4 receptor expressed in CHO cells [AID297387, Type: Literature]5-hydroxytryptamine receptor 4 [gi:12644029]
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17
[SID103209519]
IC50 0.0135-hydroxytryptamine 4 receptor antagonist activity, concentration which gave 50% reduction of the 5-HT-induced contractions in the guinea pig ileum [AID6152, Type: Literature]5-hydroxytryptamine receptor 4 [gi:6224984]
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18
[SID103209519]
IC50 0.013Antagonist activity was calculated as the concentration which produced a 50% reduction in the submaximal of 5-HT induced contractions guinea pig ileum [AID78004, Type: Literature]
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19
[SID103209519]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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20
[SID50104812]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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