matairesinol (CID 119205) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(14)
 
 
Unspecified(8)
 
 
Top Targets:
LamG(2)
 
 
Myc N(1)
 
 
P53(1)
 
 
PTZ00435(1)
 
 
RHD-n NFkB1(1)
 
 
BioAssay Types:
Literature(18)
 
 
 
Screening(10)
 
 
BioActivity Types:
IC50(8)
 
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 32    Data Row: 32   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103436031]
EC50 2Antiviral activity against HIV1 in human H9 cells assessed as inhibition of viral replication [AID357033, Type: Literature]
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2
[SID103436031]
IC50 5Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs [AID436320, Type: Literature]
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3
[SID103436031]
IC50 21.9Cytotoxicity against human H9 cells [AID357032, Type: Literature]
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4
[SID103436031]
IC50 23.65Anticancer activity against human XF498 cells by SRB assay [AID591310, Type: Literature]
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5
[SID103436031]
IC50 23.8Anticancer activity against human A549 cells by SRB assay [AID591308, Type: Literature]
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6
[SID103436031]
 Induction of apoptosis in human EBV deficient BL41 cells assessed as condensed and fragmented nuclei at 25 to 100 uM after 18 hrs by epifluorescent microscopy [AID426070, Type: Literature]
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7
[SID103436031]
 Induction of apoptosis in human E2R cells expressing EBV assessed as condensed and fragmented nuclei at 25 to 100 uM after 18 hrs by epifluorescent microscopy [AID426071, Type: Literature]
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8
[SID103436031]
 Antioxidant activity in human E2R cells assessed as intracellular peroxide level at 25 to 100 uM after 1 hr by flowcytometry in presence of DCFH-DA [AID426072, Type: Literature]
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9
[SID103436031]
 Antioxidant activity assessed as DPPH radical scavenging activity [AID333834, Type: Literature]
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10
[SID103436031]
 Antioxidant activity assessed as AAPH radical scavenging activity after 3 hrs [AID333835, Type: Literature]
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11
[SID103436031]
IC50 30Anticancer activity against human SKOV3 cells by SRB assay [AID591307, Type: Literature]
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12
[SID103436031]
IC50 30Anticancer activity against human SK-MEL-2 cells by SRB assay [AID591309, Type: Literature]
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13
[SID103436031]
IC50 52Displacement of [3H]DHT from human serum SHBG [AID399375, Type: Literature]Sex hormone-binding globulin [gi:134907]
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14
[SID103436031]
IC50 94.53Antiinflammatory activity in mouse BV2 cells assessed as inhibition of lipopolysaccharide induced NO production [AID591311, Type: Literature]
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15
[SID103436031]
 Inhibitory activity against 3'-processing by HIV-1 Integrase at 100 uM [AID91438, Type: Literature]Integrase [gi:82312013]
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16
[SID103436031]
 Inhibitory activity against strand transfer by HIV-1 Integrase at 100 uM [AID91560, Type: Literature]Integrase [gi:82312013]
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17
[SID103436031]
 Therapeutic index, ratio of IC50 for human H9 cells to EC50 for HIV1 [AID357034, Type: Literature]
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18
[SID103436031]
 Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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19
[SID103436031]
 Antifungal ativity against Aspergillus niger CECT 2089 [AID332522, Type: other]
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20
[SID103436031]
 Antifungal ativity against Penicillium [AID332523, Type: other]
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21
[SID103436031]
 Antiviral activity against HSV1 at 40 ug/ml [AID332524, Type: other]
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22
[SID103436031]
 Antiviral activity against VSV at 40 ug/ml [AID332525, Type: other]
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23
[SID85843799]
 Fluorescence Cell-Based Primary HTS to Measure Inhibition of Y box Binding Protein 1 Expression [AID434959, Type: screening]
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24
[SID85843799]
 Luminescence Homogenous Primary HTS to Identify Inhibitors of STK33 Activity [AID2322, Type: screening]
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25
[SID85843799]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of the Sonic Hedgehog Signaling Pathway [AID2313, Type: screening]
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26
[SID85843799]
 Luminescence Cell-Based Primary HTS to Identify Re-Activators of the P53 Mutant Pathway Measured in Cell-Based System Using Plate Reader - 2071-01_Activator_SinglePoint_HTS_Activity [AID624151, Type: screening]
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27
[SID85843799]
 Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity [AID624156, Type: screening]
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28
[SID85843799]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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29
[SID85843799]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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30
[SID85843799]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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31
[SID85843799]
 SMM c-myc Measured in Biochemical System Using Small Molecule MicroArray - 2081-01_Other_SinglePoint_HTS_Activity [AID624141, Type: screening]MYC gene product [Homo sapiens] [gi:71774083]
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32
[SID85843799]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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33
[SID85843799]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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34
[SID85843799]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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35
[SID85843799]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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36
[SID85843799]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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37
[SID85843799]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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38
[SID85843799]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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39
[SID85843799]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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40
[SID85843799]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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41
[SID85843799]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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42
[SID85843799]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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