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marimastat (CID 119031) - Compound BioActivity Data
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BioActivity Outcomes:
Active(91)
 
 
Inactive(25)
 
 
Unspecified(24)
 
 
Top Targets:
ZnMc TACE lik..(15)
 
 
 
HX(12)
 
 
 
ZnMc MMP(10)
 
 
 
NR DBD CAR(3)
 
 
PRP(3)
 
 
 
BioAssay Types:
Literature(99)
 
 
 
Screening(33)
 
 
 
Confirmatory(8)
 
 
BioActivity Types:
IC50(65)
 
 
Ki(15)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 138    Data Row: 140   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103185380]
Ki 0.0004Inhibition of recombinant human tumor necrosis factor-alpha converting enzyme [AID215597, Type: Literature]Disintegrin and metalloproteinase domain-containing protein 17 [gi:14423632]
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2
[SID103185380]
Ki 0.0004Inhibition of recombinant human TNF-alpha converting enzyme (TACE) [AID210018, Type: Literature]Disintegrin and metalloproteinase domain-containing protein 17 [gi:14423632]
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3
[SID103185380]
IC50 0.00041In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay [AID107333, Type: Literature]
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4
[SID103185380]
IC50 0.00047Inhibition of Matrix metalloprotease-8 (MMP-8) in fluorimetric assay [AID107991, Type: Literature]
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5
[SID103185380]
Ki 0.0006Inhibitory potency against Matrix metalloprotease-2 (MMP-2) [AID107344, Type: Literature]
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6
[SID103185380]
Ki 0.0007Inhibitory potency against Matrix metalloprotease-1 (MMP-1) [AID109221, Type: Literature]
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7
[SID103185380]
IC50 0.00075Inhibitory activity against human Matrix metalloprotease-2 [AID107160, Type: Literature]
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8
[SID103185380]
IC50 0.0007550 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2 [AID107168, Type: Literature]
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9
[SID103185380]
IC50 0.00078In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assay [AID109078, Type: Literature]
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10
[SID103185380]
IC50 0.00079In vitro selective inhibition against Matrix metalloprotease-9 (MMP-9) using fluorimetric assay [AID108303, Type: Literature]
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11
[SID103185380]
IC50 0.00085In vitro inhibitory activity against matrix metalloprotease 2 isolated from human HT1080 fibrosarcoma cells induced with TNF [AID104925, Type: Literature]
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12
[SID103185380]
Ki 0.001In vitro inhibition of human MMP-9. [AID108162, Type: Literature]
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13
[SID103185380]
Ki 0.001In vitro inhibition of human MMP-1. [AID108935, Type: Literature]
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14
[SID103185380]
IC50 0.0011In vitro inhibitory activity against matrix metalloprotease 1 isolated from the culture medium of human skin fibroblasts induced with PMA [AID104923, Type: Literature]
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15
[SID103185380]
Ki 0.0011Inhibition of recombinant human matrix metalloprotease-1 [AID108931, Type: Literature]Interstitial collagenase [gi:116852]
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16
[SID103185380]
Ki 0.0011Inhibition of Recombinant human matrix metalloprotease-1 [AID108932, Type: Literature]Interstitial collagenase [gi:116852]
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17
[SID103185380]
IC50 0.0012Inhibition of Matrix metalloprotease-13 (MMP-13) in fluorimetric assay [AID109417, Type: Literature]
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18
[SID103185380]
IC50 0.0015Inhibitory activity against matrix metalloprotease-1 (MMP1) [AID108894, Type: Literature]
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19
[SID103185380]
IC50 0.0015Inhibition of matrix metalloprotease-1 [AID104554, Type: Literature]Interstitial collagenase [gi:116852]
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20
[SID103185380]
IC50 0.0015Inhibition of Matrix metalloprotease-1 [AID108758, Type: Literature]Interstitial collagenase [gi:116852]
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