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marimastat (CID 119031) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(89)
 
 
Inactive(24)
 
 
Unspecified(24)
 
 
Top Targets:
ZnMc TACE lik..(15)
 
 
 
HX(12)
 
 
 
ZnMc MMP(10)
 
 
 
NR DBD CAR(3)
 
 
PRP(3)
 
 
 
BioAssay Types:
Literature(97)
 
 
 
Screening(32)
 
 
 
Confirmatory(4)
 
 
BioActivity Types:
IC50(63)
 
 
Ki(15)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 136    Data Row: 137   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103185380]
Ki 0.0004Inhibition of recombinant human TNF-alpha converting enzyme (TACE) [AID210018, Type: Literature]Disintegrin and metalloproteinase domain-containing protein 17 [gi:14423632]
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2
[SID103185380]
Ki 0.0004Inhibition of recombinant human tumor necrosis factor-alpha converting enzyme [AID215597, Type: Literature]Disintegrin and metalloproteinase domain-containing protein 17 [gi:14423632]
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3
[SID103185380]
IC50 0.00041In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay [AID107333, Type: Literature]
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4
[SID103185380]
IC50 0.00047Inhibition of Matrix metalloprotease-8 (MMP-8) in fluorimetric assay [AID107991, Type: Literature]
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5
[SID103185380]
Ki 0.0006Inhibitory potency against Matrix metalloprotease-2 (MMP-2) [AID107344, Type: Literature]
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6
[SID103185380]
Ki 0.0007Inhibitory potency against Matrix metalloprotease-1 (MMP-1) [AID109221, Type: Literature]
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7
[SID103185380]
IC50 0.00075Inhibitory activity against human Matrix metalloprotease-2 [AID107160, Type: Literature]
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8
[SID103185380]
IC50 0.0007550 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2 [AID107168, Type: Literature]
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9
[SID103185380]
IC50 0.00078In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assay [AID109078, Type: Literature]
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10
[SID103185380]
IC50 0.00079In vitro selective inhibition against Matrix metalloprotease-9 (MMP-9) using fluorimetric assay [AID108303, Type: Literature]
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11
[SID103185380]
IC50 0.00085In vitro inhibitory activity against matrix metalloprotease 2 isolated from human HT1080 fibrosarcoma cells induced with TNF [AID104925, Type: Literature]
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12
[SID103185380]
Ki 0.001In vitro inhibition of human MMP-1. [AID108935, Type: Literature]
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13
[SID103185380]
Ki 0.001In vitro inhibition of human MMP-9. [AID108162, Type: Literature]
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14
[SID103185380]
Ki 0.0011Inhibition of recombinant human matrix metalloprotease-1 [AID108931, Type: Literature]Interstitial collagenase [gi:116852]
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15
[SID103185380]
Ki 0.0011Inhibition of Recombinant human matrix metalloprotease-1 [AID108932, Type: Literature]Interstitial collagenase [gi:116852]
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16
[SID103185380]
IC50 0.0011In vitro inhibitory activity against matrix metalloprotease 1 isolated from the culture medium of human skin fibroblasts induced with PMA [AID104923, Type: Literature]
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17
[SID103185380]
IC50 0.0012Inhibition of Matrix metalloprotease-13 (MMP-13) in fluorimetric assay [AID109417, Type: Literature]
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18
[SID103185380]
IC50 0.0015Inhibition of Matrix metalloprotease-1 [AID108758, Type: Literature]Interstitial collagenase [gi:116852]
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19
[SID103185380]
IC50 0.0015Inhibitory activity against matrix metalloprotease-1 (MMP1) [AID108894, Type: Literature]
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20
[SID103185380]
IC50 0.0015Inhibition of matrix metalloprotease-9 [AID104919, Type: Literature]Matrix metalloproteinase-9 [gi:269849668]
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21
[SID103185380]
IC50 0.0015Inhibition of matrix metalloprotease-1 [AID104554, Type: Literature]Interstitial collagenase [gi:116852]
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22
[SID103185380]
IC50 0.0016Inhibition of Matrix metalloprotease-9 [AID108140, Type: Literature]Matrix metalloproteinase-9 [gi:269849668]
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23
[SID103185380]
IC50 0.0016Inhibitory activity against matrix metalloprotease-9 (MMP9) [AID108147, Type: Literature]
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24
[SID103185380]
IC50 0.0018Inhibitory activity against matrix metalloprotease-2 (MMP2) [AID107172, Type: Literature]
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25
[SID103185380]
IC50 0.0018Inhibition of Matrix metalloprotease-2 [AID107159, Type: Literature]72 kDa type IV collagenase [gi:116856]
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26
[SID103185380]
IC50 0.00182Activity against deletion mutant of MT1-MMP lacking the transmembrane domain (deltaMT1) [AID220527, Type: Literature]
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27
[SID103185380]
IC50 0.002Inhibitory activity against human Matrix metalloprotease-13 [AID109377, Type: Literature]
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28
[SID103185380]
IC50 0.00250 percent inhibition of human Matrix metalloprotease-13 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2 [AID109382, Type: Literature]
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29
[SID103185380]
IC50 0.002Inhibition of HNC MMP-8 [AID104912, Type: Literature]
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30
[SID103185380]
IC50 0.002Activity against Matrix metalloprotease-1 (MMP-1). [AID108731, Type: Literature]
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31
[SID103185380]
IC50 0.002Inhibition of Coll-3 MMP-13 [AID104708, Type: Literature]
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32
[SID103185380]
IC50 0.002Inhibition of matrix metalloprotease-2 [AID104711, Type: Literature]72 kDa type IV collagenase [gi:116856]
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33
[SID103185380]
IC50 0.002Inhibition of MMP-8 (matrix metalloprotease-8) [AID107849, Type: Literature]Neutrophil collagenase [gi:116862]
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34
[SID103185380]
Ki 0.0024Inhibition of human MMP-3. [AID107657, Type: Literature]Stromelysin-1 [gi:116857]
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35
[SID103185380]
IC50 0.0029Inhibitory activity against human Matrix metalloprotease-1 [AID108751, Type: Literature]
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36
[SID103185380]
IC50 0.002950 percent inhibition of human Matrix metalloprotease-1 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2 [AID108766, Type: Literature]
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37
[SID103185380]
IC50 0.0034Inhibitory activity against matrix metalloprotease-13 (MMP13) [AID109384, Type: Literature]
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38
[SID103185380]
IC50 0.0034Inhibition of Matrix metalloprotease-13 [AID109264, Type: Literature]Collagenase 3 [gi:1168998]
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39
[SID103185380]
IC50 0.0035Inhibition of matrix metalloprotease-13 [AID104707, Type: Literature]Collagenase 3 [gi:1168998]
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40
[SID103185380]
IC50 0.0038Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood. [AID215431, Type: Literature]
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41
[SID103185380]
IC50 0.0038Inhibition of TACE [AID347023, Type: Literature]
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42
[SID103185380]
IC50 0.0041Inhibition of Matrix metalloprotease-7 (MMP-7) in fluorimetric assay [AID107840, Type: Literature]
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43
[SID103185380]
IC50 0.0044Activity against Matrix metalloprotease-3 (MMP-3). [AID107358, Type: Literature]
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44
[SID103185380]
IC50 0.005Inhibitory activity against MMP-1 (Matrix metalloprotease-1) [AID108749, Type: Literature]
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45
[SID103185380]
IC50 0.00550% inhibition of human recombinant fibroblast collagenase (MMP-1, HFC) [AID73172, Type: other]
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46
[SID103185380]
IC50 0.005Inhibition of HFC MMP-1 [AID104556, Type: Literature]
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47
[SID103185380]
IC50 0.0051Activity against Matrix metalloprotease-2 (MMP-2). [AID109580, Type: Literature]
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48
[SID103185380]
IC50 0.006Compound concentration for 50% inhibition of human recombinant gelatinase A (MMP-2). [AID74476, Type: other]
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49
[SID103185380]
IC50 0.006Inhibition of Gel-A MMP-2 [AID104713, Type: Literature]
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50
[SID103185380]
Ki 0.0063Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE) [AID215264, Type: Literature]Disintegrin and metalloproteinase domain-containing protein 17 [gi:14423632]
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