gamma-Aminobutyric Acid (CID 119) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(89)
 
 
Inactive(1089)
 
 
Inconclusive(61)
 
 
Unspecified(163)
 
 
Top Targets:
Neur chan LBD(40)
 
 
 
 
7TM GPCR Srx(23)
 
 
 
HELICc(13)
 
 
 
p450(13)
 
 
 
 
Tubulin-bindi..(12)
 
 
BioAssay Types:
Confirmatory(521)
 
 
 
 
 
Screening(469)
 
 
 
 
Literature(311)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(423)
 
 
 
 
 
IC50(95)
 
 
 
 
 
EC50(31)
 
 
 
 
Ki(6)
 
 
 
AC50(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1098    Data Row: 1402   Total Pages: 29   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103173784]
IC50 0.013Inhibition of [3H]GABA binding in GABAA receptor in rat brain synaptic membranes [AID267285, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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2
[SID103173784]
IC50 0.015Displacement of [3H]muscimol from GABA-A receptor in Sprague-Dawley rat spinal cord [AID270052, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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3
[SID103173784]
IC50 0.015In vitro inhibition of [3H]THIP binding to Gamma-aminobutyric acid receptor in rat brain synaptic membranes [AID71437, Type: Literature]
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4
[SID103173784]
IC50 0.015Displacement of [3H]muscimol from GABAA receptor in Sprague-Dawley rat spinal cord brainstem membranes [AID286350, Type: Literature]
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5
[SID103173784]
IC50 0.017Inhibition of [3H]CGP-27492 binding to Gamma-aminobutyric acid type B receptor of rat cortex [AID71401, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
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6
[SID103173784]
IC50 0.018Binding affinity against Gamma-aminobutyric acid A receptor in rat cerebral cortex [AID71822, Type: Literature]
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7
[SID103173784]
IC50 0.02Displacement of [3H]gamma-aminobutyric acid from sodium-independent Gamma-aminobutyric acid (GABA-A) receptor synaptic membrane binding sites from rat brain tissue [AID71429, Type: Literature]
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8
[SID103173784]
IC50 0.022Inhibitory effect was measured for [3H]GABA-uptake from rat synaptosomal membrane [AID71443, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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9
[SID103173784]
IC50 0.024Displacement of [3H]muscimol from GABA-A receptor in Sprague-Dawley rat cerebral cortex [AID270053, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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10
[SID103173784]
IC50 0.024Displacement of [3H]muscimol from GABAA receptor in Sprague-Dawley rat cerebral cortex membranes [AID286351, Type: Literature]
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11
[SID103173784]
IC50 0.025In vitro inhibition of [3H]P4S binding to Gamma-aminobutyric acid receptor of rat brain synaptic membranes [AID71436, Type: Literature]
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12
[SID103173784]
Ki 0.025Displacement of [3H]gamma-amino butyric acid from Gamma-aminobutyric acid (GABA-A) receptor of rat ganglion neurons [AID71568, Type: Literature]
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13
[SID103173784]
IC50 0.025Binding affinity in vivo for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]-GABA agonist from rat brain preparations after iv injection. [AID72155, Type: Literature]
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14
[SID103173784]
IC50 0.025Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellum [AID71258, Type: Literature]
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15
[SID103173784]
IC50 0.027Inhibition of rat GABA receptor [AID566253, Type: Literature]
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16
[SID103173784]
IC50 0.029Displacement of [3H]- muscimol from GABA-A receptor from rat cerebellum membrane at 0.022-0.039 uM [AID71421, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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17
[SID103173784]
IC50 0.03Displacement of [3H]baclofen from Gamma-aminobutyric acid type B receptor of rat brain membranes [AID71399, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
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18
[SID103173784]
IC50 0.03In vitro binding affinity against Gamma-aminobutyric acid type B receptor in rat brain synaptic membranes at pH 7.4 [AID71391, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
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19
[SID103173784]
IC50 0.03Inhibition of Gamma-aminobutyric acid type B receptor of rat cortex [AID71392, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
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20
[SID103173784]
IC50 0.03Inhibition of [3H]GABA binding to gamma-aminobutyric-acid A (GABA-A) receptor [AID72296, Type: Literature]
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21
[SID103173784]
IC50 0.03Displacement of [3H]GABA from Gamma-aminobutyric acid A receptor ofrat brain membranes [AID71830, Type: Literature]
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22
[SID103173784]
IC50 0.033In vitro affinity for GABA binding sites on purified synaptic membranes from rat brain. [AID71431, Type: Literature]
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23
[SID103173784]
IC50 0.033Inhibition of [3H]GABA binding to Gamma-aminobutyric acid receptor of rat brain synaptosomal membranes [AID71448, Type: Literature]
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24
[SID103173784]
IC50 0.033In vitro binding affinity against Gamma-aminobutyric acid A receptor in rat brain synaptic membranes at pH 7.1 [AID72156, Type: Literature]
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25
[SID103173784]
IC50 0.033In vitro inhibition of [3H]GABA binding to Gamma-aminobutyric acid receptor of rat brain synaptic membranes [AID71435, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-1 [gi:120782]
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26
[SID103173784]
IC50 0.04Inhibition of [3H]baclofen binding to rat gamma-aminobutyric acid type B receptor. [AID71390, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
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27
[SID103173784]
IC50 0.044Inhibition of GABA receptor [AID340244, Type: Literature]
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28
[SID103173784]
IC50 0.06In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranes [AID71389, Type: other]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
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29
[SID103173784]
IC50 0.068Displacement of radiolabeled GABA from GABA receptor [AID346419, Type: Literature]
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30
[SID103173784]
IC50 0.07Inhibition of [3H]GABA Binding to synaptic membranes from rat cerebellum in receptor binding assay [AID179951, Type: Literature]
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31
[SID103173784]
IC50 0.1Inhibition of [3H]muscimol binding to gamma-aminobutyric-acid A (GABA-A) receptor [AID71837, Type: Literature]
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32
[SID103173784]
IC50 0.128Inhibition of [3H]muscimol binding to GABA-A receptor from rat cortex [AID71998, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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33
[SID103173784]
Ki 0.176Displacement of [3H]GABA from GABAB receptor in presence of isoguvacine [AID337892, Type: other]
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34
[SID103173784]
Ki 0.2Displacement of [3H]gamma-amino butyric acid from Gamma-aminobutyric acid (GABA-A) receptor of human cerebellar cortex preparation [AID71287, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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35
[SID103173784]
EC50 0.43Agonist activity at GABAC rho 1 receptor expressed in tsA-201 cells by FMP assay [AID296916, Type: Literature]
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36
[SID103173784]
EC50 0.8Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method [AID406570, Type: Literature]Gamma-aminobutyric acid receptor subunit rho-1 [gi:223590210]
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37
[SID103173784]
EC50 0.8Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method [AID406570, Type: Literature]Gamma-aminobutyric acid receptor subunit rho-1 [gi:223590210]
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38
[SID103173784]
EC50 1.19Agonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method [AID321738, Type: Literature]Gamma-aminobutyric acid receptor subunit rho-1 [gi:223590210]
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39
[SID103173784]
EC50 1.19Agonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method [AID321738, Type: Literature]Gamma-aminobutyric acid receptor subunit rho-1 [gi:223590210]
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40
[SID103173784]
IC50 1.45Affinity for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]gabazine antagonist from rat brain preparations. [AID72153, Type: Literature]
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41
[SID103173784]
EC50 1.5Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2 [AID73542, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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42
[SID103173784]
EC50 1.7Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method [AID406573, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 1 [gi:12643873]
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43
[SID103173784]
EC50 1.7Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method [AID406573, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 1 [gi:12643873]
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44
[SID103173784]
Kd 1.7Agonist activity against Gamma-aminobutyric acid type C (GABA-C) receptor derived from bovine retinal RNA expressed in Xenopus oocytes [AID71408, Type: Literature]
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45
[SID103173784]
IC50 1.8H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound [AID242581, Type: Literature]Sodium- and chloride-dependent GABA transporter 1 [gi:128609]
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46
[SID103173784]
IC50 2Inhibition of high affinity neuronal GABA uptake by synaptosomes of rat brain membrane [AID180670, Type: Literature]Sodium- and chloride-dependent GABA transporter 1 [gi:128609]
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47
[SID103173784]
IC50 2In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain. [AID71433, Type: Literature]Sodium- and chloride-dependent GABA transporter 1 [gi:128609]
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48
[SID103173784]
IC50 2Concentration inhibiting GABA uptake rat brain synaptosomes. [AID196024, Type: Literature]
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49
[SID103173784]
IC50 2.6Inhibition of GABA uptake from rat diencephalon-midbrain, [AID179937, Type: Literature]
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50
[SID103173784]
IC50 2.6H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determined [AID242583, Type: Literature]Sodium- and chloride-dependent GABA transporter 1 [gi:128609]
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