Xanthine (CID 1188) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(56)
 
 
Inconclusive(5)
 
 
Unspecified(19)
 
 
Top Targets:
NR LBD PPAR(5)
 
 
NR LBD TR(4)
 
 
 
NR LBD RXR li..(2)
 
 
NR LBD GR(2)
 
 
NR LBD Fxr(2)
 
 
 
BioAssay Types:
Literature(27)
 
 
 
 
 
Confirmatory(27)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(26)
 
 
 
IC50(5)
 
 
Ki(5)
 
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 74    Data Row: 82   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103503924]
Ki 1.96Inhibition of GDA by colorimetric assay [AID502390, Type: Literature]
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2
[SID103503924]
Km 21.4Activity of bovine xanthine oxidase [AID363291, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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3
[SID103503924]
EC50 100Relexant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. [AID74022, Type: Literature]
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4
[SID103503924]
Ki 130Inhibition of adenosine stimulated accumulation of cyclic AMP at Adenosine A2 receptor of VA13 fibroblasts of rat [AID187182, Type: Literature]Adenosine receptor A2 [gi:112939]
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5
[SID103503924]
IC50 160Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453746, Type: Literature]
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6
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4B [gi:729163]
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7
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4B [gi:729163]
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8
[SID103503924]
Ki 200Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]CPX. [AID32155, Type: Literature]
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9
[SID103503924]
IC50 220Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453743, Type: Literature]
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10
[SID103503924]
IC50 230Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453745, Type: Literature]
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11
[SID103503924]
IC50 370Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453742, Type: Literature]
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12
[SID103503924]
IC50 3600Inhibitory concentration against Enzymatic A chain of ricin (RTA) using Artemia salina ribosomes [AID66419, Type: Literature]Ricin [gi:132567]
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13
[SID103503924]
 Compound was screened for their ability to potentiate [Ca2+] release induced by cADRP(an endogenous modulator of ryanodine receptor) in sea urchin egg homogenates at a concentration of 2 mM [AID202405, Type: Literature]
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14
[SID103503924]
 Binding affinity to DNA intercalator Acridine orange. [AID55471, Type: Literature]
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15
[SID103503924]
 Inhibition of Plasmodium falciparum HGXPRT at pH 8.5 [AID274563, Type: Literature]
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16
[SID103503924]
 Positive chronotropic effect on isolated guinea pig right atrium (heart stimulation). [AID75917, Type: Literature]
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17
[SID103503924]
 Ratio of stimulatory activity in right atrium to relaxant activity in tracheal muscle [AID227877, Type: Literature]
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18
[SID103503924]
 Acid dissociation constant was determined [AID239883, Type: Literature]
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19
[SID103503924]
 Insulin release in rat pancreatic beta-cells after 15 minutes of administration at 1 mM was measured [AID252792, Type: Literature]
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20
[SID103503924]
 Insulin release in rat pancreatic beta-cells (PBS-rinsing of the islets) after 15 minutes of administration at 1 mM was measured [AID252796, Type: Literature]
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21
[SID103503924]
Ki Inhibition of Plasmodium falciparum HGXPRT at pH 7.4 [AID274550, Type: Literature]
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22
[SID26757757]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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23
[SID26757757]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_1, Type: other]
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24
[SID26757757]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_2, Type: other]
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25
[SID26757757]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_3, Type: other]
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26
[SID26757757]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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27
[SID26757757]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_5, Type: other]
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28
[SID26757757]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
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29
[SID26757757]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
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30
[SID26757757]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_8, Type: other]
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31
[SID92121051]
 A screen for compounds that inhibit nucleocapsid/RNA interactions in Rift Valley Fever Virus [AID651828, Type: other]Nucleoprotein [gi:127925]
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32
[SID11536787]
 NMR Based Screening Assay for the substrate binding domain of the chaperone DnaK [AID1033, Type: screening]DnaK protein homolog [Escherichia coli] [gi:216546]
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33
[SID11536787]
 NMR Based Screening Assay For Novel Chemical Probes Targeting The FRB Domain of mTOR [AID1648, Type: other]Chain A, Nmr Solution Structure Of The Frb Domain Of Mtor [gi:159164579]
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34
[SID92121051]
 A screen for compounds that inhibit the bacterial siderophore biosynthetic enzyme MbtI [AID493033, Type: other]Isochorismate synthase/isochorismate-pyruvate lyase mbtI [gi:81706979]
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35
[SID11536787]
 NMR Based Screening Assay for Novel Chemotypes against influenza A virus [AID1549, Type: other]M2 [Influenza A virus (A/TW/4845/1999(H1N1))] [gi:89033149]
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36
[SID26757757]
Potency qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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37
[SID26757757]
Potency qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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38
[SID26757757]
Potency qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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39
[SID26757757]
Potency qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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40
[SID26757757]
Potency qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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41
[SID26757757]
Potency qHTS assay for small molecule antagonists of androgen receptor signaling [AID588516, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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42
[SID26757757]
Potency qHTS assay for small molecule antagonists of androgen receptor signaling [AID588516, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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43
[SID26757757]
Potency qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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44
[SID26757757]
Potency qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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45
[SID26757757]
Potency qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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46
[SID26757757]
Potency qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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47
[SID26757757]
Potency qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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48
[SID26757757]
Potency qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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49
[SID26757757]
Potency qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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50
[SID26757757]
Potency qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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