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Xanthine (CID 1188) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(63)
 
 
Inconclusive(5)
 
 
Unspecified(23)
 
 
Top Targets:
NR LBD PPAR(5)
 
 
NR LBD TR(4)
 
 
 
HDc(4)
 
 
7TM GPCR Srsx(3)
 
 
NR LBD ER(2)
 
 
BioAssay Types:
Literature(32)
 
 
 
 
 
Confirmatory(32)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(31)
 
 
 
Ki(9)
 
 
 
IC50(5)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 82    Data Row: 94   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103503924]
Ki 1.96Inhibition of GDA by colorimetric assay [AID502390, Type: Literature]
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2
[SID103503924]
Km 21.4Activity of bovine xanthine oxidase [AID363291, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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3
[SID103503924]
Antiapicomplexan activity against Toxoplasma gondii THdhxgTRP tachyzoites harboring insertional mutation assessed as growth inhibition after 6 weeks [AID705460, Type: Literature]
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4
[SID103503924]
EC50 100Relexant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. [AID74022, Type: Literature]
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5
[SID103503924]
Ki 130Inhibition of adenosine stimulated accumulation of cyclic AMP at Adenosine A2 receptor of VA13 fibroblasts of rat [AID187182, Type: Literature]Adenosine receptor A2b [gi:112939]
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6
[SID103503924]
Ki 130Inhibition of adenosine stimulated accumulation of cyclic AMP at Adenosine A2 receptor of VA13 fibroblasts of rat [AID187182, Type: Literature]Adenosine receptor A2a [gi:8928539]
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7
[SID103503924]
IC50 160Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453746, Type: Literature]
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8
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4B [gi:729163]
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9
[SID103503924]
Ki 200Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]CPX. [AID32155, Type: Literature]Adenosine receptor A1 [gi:1351830]
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10
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4D [gi:12644392]
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11
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4A [gi:116242706]
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12
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4C [gi:20141263]
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13
[SID103503924]
IC50 220Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453743, Type: Literature]
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14
[SID103503924]
IC50 230Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453745, Type: Literature]
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15
[SID103503924]
IC50 370Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453742, Type: Literature]
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16
[SID103503924]
Km 420Inhibition of Plasmodium falciparum HGXPRT at pH 8.5 [AID274563, Type: Literature]
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17
[SID103503924]
IC50 3600Inhibitory concentration against Enzymatic A chain of ricin (RTA) using Artemia salina ribosomes [AID66419, Type: Literature]Ricin [gi:132567]
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18
[SID103503924]
Positive chronotropic effect on isolated guinea pig right atrium (heart stimulation). [AID75917, Type: Literature]Adenosine receptor A1 [gi:1351830]
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19
[SID103503924]
Binding affinity to DNA intercalator Acridine orange. [AID55471, Type: Literature]
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20
[SID26757757]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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21
[SID103503924]
Compound was screened for their ability to potentiate [Ca2+] release induced by cADRP(an endogenous modulator of ryanodine receptor) in sea urchin egg homogenates at a concentration of 2 mM [AID202405, Type: Literature]
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22
[SID103503924]
Ratio of stimulatory activity in right atrium to relaxant activity in tracheal muscle [AID227877, Type: Literature]
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23
[SID103503924]
Acid dissociation constant was determined [AID239883, Type: Literature]
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24
[SID103503924]
Insulin release in rat pancreatic beta-cells after 15 minutes of administration at 1 mM was measured [AID252792, Type: Literature]
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25
[SID103503924]
Insulin release in rat pancreatic beta-cells (PBS-rinsing of the islets) after 15 minutes of administration at 1 mM was measured [AID252796, Type: Literature]
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26
[SID103503924]
Ki Inhibition of Plasmodium falciparum HGXPRT at pH 7.4 [AID274550, Type: Literature]
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27
[SID103503924]
Inhibition of [3H]hypoxanthine uptake into Plasmodium falciparum 3D7 at 130 uM [AID274551, Type: Literature]
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28
[SID103503924]
Antimalarial activity against Plasmodium falciparum 3D7 at 130 uM [AID274554, Type: Literature]
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29
[SID540766]
NCI Yeast Anticancer Drug Screen. Data for the rad50 strain [AID155, Type: other]
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30
[SID540766]
NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain [AID157, Type: other]
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31
[SID540766]
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain [AID161, Type: other]
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32
[SID540766]
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain [AID165, Type: other]
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33
[SID540766]
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain [AID167, Type: other]
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34
[SID540766]
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain [AID175, Type: other]
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35
[SID540766]
NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID248, Type: other]
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36
[SID26757757]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_1, Type: other]
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37
[SID26757757]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_2, Type: other]
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38
[SID26757757]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_3, Type: other]
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39
[SID26757757]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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40
[SID26757757]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_5, Type: other]
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41
[SID26757757]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
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42
[SID26757757]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
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43
[SID26757757]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_8, Type: other]
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44
[SID26757757]
Potency qHTS assay for cell viability of HEK293 cells [AID743288, Type: confirmatory]
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45
[SID26757757]
Potency qHTS assay for cell viability of the p53RE-bla HCT-116 cell line [AID743292, Type: confirmatory]
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46
[SID26757757]
Potency-Replicate_1 qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway measured by Nrf2-dependant transcriptional activity - cell viability counter screen [AID720653, Type: confirmatory]
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47
[SID103503924]
Inhibition of Escherichia coli thymidine phosphorylase at 158 uM [AID363284, Type: Literature]
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48
[SID11536787]
NMR Based Screening Assay for Influenza A RNA Promoter [AID1637, Type: other]
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49
[SID92111265]
High Throughput Screen of a Putative Kinase Compound Library to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID2842, Type: confirmatory]
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50
[SID92121051]
Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection [AID720717, Type: other]ORF 73 [Human herpesvirus 8 type M] [gi:1718329]
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