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Xanthine (CID 1188) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(63)
 
 
Inconclusive(5)
 
 
Unspecified(24)
 
 
Top Targets:
NR LBD PPAR(5)
 
 
NR LBD TR(4)
 
 
 
HDc(4)
 
 
7tm 4(3)
 
 
NR LBD ER(2)
 
 
BioAssay Types:
Literature(36)
 
 
 
 
 
Confirmatory(32)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(31)
 
 
 
Ki(11)
 
 
 
IC50(7)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 85    Data Row: 98   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103503924]
Ki 1.96Inhibition of GDA by colorimetric assay [AID502390, Type: Literature]
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2
[SID208012134]
Ki 1.96Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]
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3
[SID208012134]
Ki 1.96Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]
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4
[SID103503924]
IC50 9Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method [AID759422, Type: Literature]Acetylcholinesterase [gi:113037]
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5
[SID103503924]
Km 21.4Activity of bovine xanthine oxidase [AID363291, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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6
[SID103503924]
Antiapicomplexan activity against Toxoplasma gondii THdhxgTRP tachyzoites harboring insertional mutation assessed as growth inhibition after 6 weeks [AID705460, Type: Literature]
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7
[SID103503924]
IC50 50Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method [AID759421, Type: Literature]Cholinesterase [gi:116353]
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8
[SID103503924]
EC50 100Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. [AID74022, Type: Literature]
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9
[SID103503924]
Ki 130Inhibition of adenosine stimulated accumulation of cyclic AMP at Adenosine A2 receptor of VA13 fibroblasts of rat [AID187182, Type: Literature]Adenosine receptor A2b [gi:112939]
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10
[SID103503924]
Ki 130Inhibition of adenosine stimulated accumulation of cyclic AMP at Adenosine A2 receptor of VA13 fibroblasts of rat [AID187182, Type: Literature]Adenosine receptor A2a [gi:8928539]
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11
[SID103503924]
IC50 160Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453746, Type: Literature]
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12
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4B [gi:729163]
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13
[SID103503924]
Ki 200Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]CPX. [AID32155, Type: Literature]Adenosine receptor A1 [gi:1351830]
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14
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4D [gi:12644392]
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15
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4A [gi:116242706]
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16
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4C [gi:20141263]
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17
[SID103503924]
IC50 220Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453743, Type: Literature]
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18
[SID103503924]
IC50 230Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453745, Type: Literature]
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19
[SID103503924]
IC50 370Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453742, Type: Literature]
View
20
[SID103503924]
Km 420Inhibition of Plasmodium falciparum HGXPRT at pH 8.5 [AID274563, Type: Literature]
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