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Xanthine (CID 1188) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(63)
 
 
Inconclusive(5)
 
 
Unspecified(24)
 
 
Top Targets:
NR LBD PPAR(5)
 
 
NR LBD TR(4)
 
 
 
HDc(4)
 
 
7TM GPCR Srsx(3)
 
 
NR LBD ER(2)
 
 
BioAssay Types:
Literature(34)
 
 
 
 
 
Confirmatory(32)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(31)
 
 
 
Ki(9)
 
 
 
IC50(7)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 84    Data Row: 96   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103503924]
Ki 1.96Inhibition of GDA by colorimetric assay [AID502390, Type: Literature]
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2
[SID103503924]
IC50 9Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method [AID759422, Type: Literature]Acetylcholinesterase [gi:113037]
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3
[SID103503924]
Km 21.4Activity of bovine xanthine oxidase [AID363291, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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4
[SID103503924]
Antiapicomplexan activity against Toxoplasma gondii THdhxgTRP tachyzoites harboring insertional mutation assessed as growth inhibition after 6 weeks [AID705460, Type: Literature]
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5
[SID103503924]
IC50 50Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method [AID759421, Type: Literature]Cholinesterase [gi:116353]
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6
[SID103503924]
EC50 100Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. [AID74022, Type: Literature]
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7
[SID103503924]
Ki 130Inhibition of adenosine stimulated accumulation of cyclic AMP at Adenosine A2 receptor of VA13 fibroblasts of rat [AID187182, Type: Literature]Adenosine receptor A2b [gi:112939]
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8
[SID103503924]
Ki 130Inhibition of adenosine stimulated accumulation of cyclic AMP at Adenosine A2 receptor of VA13 fibroblasts of rat [AID187182, Type: Literature]Adenosine receptor A2a [gi:8928539]
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9
[SID103503924]
IC50 160Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453746, Type: Literature]
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10
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4B [gi:729163]
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11
[SID103503924]
Ki 200Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]CPX. [AID32155, Type: Literature]Adenosine receptor A1 [gi:1351830]
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12
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4A [gi:116242706]
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13
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4D [gi:12644392]
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14
[SID103503924]
Ki 200Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4C [gi:20141263]
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15
[SID103503924]
IC50 220Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453743, Type: Literature]
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16
[SID103503924]
IC50 230Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453745, Type: Literature]
View
17
[SID103503924]
IC50 370Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453742, Type: Literature]
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18
[SID103503924]
Km 420Inhibition of Plasmodium falciparum HGXPRT at pH 8.5 [AID274563, Type: Literature]
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19
[SID103503924]
IC50 3600Inhibitory concentration against Enzymatic A chain of ricin (RTA) using Artemia salina ribosomes [AID66419, Type: Literature]Ricin [gi:132567]
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20
[SID103503924]
Positive chronotropic effect on isolated guinea pig right atrium (heart stimulation). [AID75917, Type: Literature]Adenosine receptor A1 [gi:1351830]
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