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Uric Acid (CID 1175) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(77)
 
 
Unspecified(30)
 
 
Top Targets:
MFS(11)
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD GR(4)
 
 
NR LBD TR(3)
 
 
BioAssay Types:
Confirmatory(53)
 
 
Literature(23)
 
 
 
 
Summary(15)
 
 
Screening(2)
 
 
BioActivity Types:
Potency(66)
 
 
IC50(5)
 
 
Ki(3)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 110    Data Row: 110   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103209253]
Ki 4.34Inhibition of GDA by colorimetric assay [AID502390, Type: Literature]
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2
[SID46392403]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Human Liver Glycogen Phosphorylase Complexed With Uric Acid, N-Acetyl- Beta-D-Glucopyranosylamine, And Cp-403,700 [gi:27065325]
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3
[SID103209253]
Reducing activity to scavenge 10 uM 1, 1-diphenylpicrylhydrazyl (DPPH) [AID230361, Type: Literature]
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4
[SID103209253]
IC50 60Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453745, Type: Literature]
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5
[SID103209253]
IC50 96Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453743, Type: Literature]
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6
[SID103209253]
IC50 100Inhibition of N-terminal His6-tagged Trypanosoma brucei CTPS assessed as NH3-dependent CTP formation by continuous spectrophotometric assay [AID613867, Type: Literature]
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7
[SID103209253]
IC50 101Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453746, Type: Literature]
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8
[SID103209253]
IC50 113Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453742, Type: Literature]
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9
[SID103209253]
Ki 275TP_TRANSPORTER: inhibition of Estrone sulfate in Xenopus laevis oocytes [AID681040, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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10
[SID103209253]
Km 947TP_TRANSPORTER: uptake in OAT1-expressing S2 cells [AID679379, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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11
[SID103209253]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681141, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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12
[SID103209253]
TP_TRANSPORTER: inhibition of PAH uptake (PAH: 2 uM, Urate: 2000 uM) in Xenopus laevis oocytes [AID679517, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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13
[SID103209253]
TP_TRANSPORTER: inhibition of PAH uptake (PAH: 1 uM, Urate: 100 uM) in Xenopus laevis oocytes [AID679521, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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14
[SID103209253]
TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679373, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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15
[SID103209253]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681362, Type: other]Solute carrier family 22 member 6 [gi:81886651]
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16
[SID103209253]
TP_TRANSPORTER: inhibition of PAH uptake (PAH: 50 uM, Urate; 1000 uM) in Xenopus laevis oocytes [AID681749, Type: other]Solute carrier family 22 member 6 [gi:81886651]
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17
[SID103209253]
TP_TRANSPORTER: inhibition of benzylpenicillin uptake by Urate at a concentration of 1000uM in Oat3-expressing oocyte cells [AID679450, Type: other]Solute carrier family 22 member 8 [gi:124015184]
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18
[SID103209253]
Partition coefficient (logP) [AID23266, Type: Literature]
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19
[SID103209253]
Tested for antioxidant activity using bovine heart mitochondria and iron(II) / dihydroxy fumaric acid (DHF) at 100 uM [AID54305, Type: Literature]
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20
[SID103209253]
Binding affinity to DNA intercalator Acridine orange. [AID55471, Type: Literature]
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21
[SID103209253]
Percent inhibition at 100 uM against peroxidation of liposomal suspension of dilinoleoylphosphatidylcholine (DPLC) intiated by DMVN at 40 degree Centigrade [AID227565, Type: Literature]
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22
[SID103209253]
Percent inhibition at 100 uM against peroxidation of methyl linoleate / DMVN in TBA /methanol medium at 40 degree Centigrade [AID227566, Type: Literature]
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23
[SID103209253]
TP_TRANSPORTER: trans-stimulation in Xenopus laevis oocytes [AID678813, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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24
[SID103209253]
TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID678986, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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25
[SID103209253]
Acid dissociation constant was determined [AID239883, Type: Literature]
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26
[SID103209253]
Insulin release in rat pancreatic beta-cells after 15 minutes of administration at 1 mM was measured [AID252792, Type: Literature]
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27
[SID103209253]
Insulin release in rat pancreatic beta-cells after 15 minutes of administration of the K-salt of compound at 1 mM was measured [AID252793, Type: Literature]
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28
[SID103209253]
Insulin release in rat pancreatic beta-cells after 15 minutes of administration of the Na-salt of compound at 1 mM was measured [AID252794, Type: Literature]
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29
[SID103209253]
Insulin release in rat pancreatic beta-cells after 15 minutes of administration of the NH4-salt of compound at 1 mM was measured [AID252795, Type: Literature]
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30
[SID103209253]
Antioxidant activity assessed as oxygen radical scavenging activity in presence of human plasma by ORAC method relative to control [AID326215, Type: Literature]
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31
[SID103209253]
Antioxidant activity in human plasma assessed as inhibition of cholesteryl ester hydroperoxide formation after 60 mins relative to control [AID326216, Type: Literature]
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32
[SID103209253]
Antioxidant activity assessed as oxygen radical absorbance capacity index value by fluorescein protection assay [AID389190, Type: Literature]
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33
[SID103209253]
Antioxidant activity assessed as oxygen radical absorbance capacity index value by pyrogallol red protection assay [AID389192, Type: Literature]
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34
[SID70376]
NCI Yeast Anticancer Drug Screen. Data for the rad50 strain [AID155, Type: other]
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35
[SID70376]
NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain [AID157, Type: other]
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36
[SID70376]
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain [AID161, Type: other]
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37
[SID70376]
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain [AID165, Type: other]
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38
[SID70376]
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain [AID167, Type: other]
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39
[SID70376]
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain [AID175, Type: other]
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40
[SID103209253]
Ki Inhibition of Trypanosoma cruzi dihydroorotate dehydrogenase by isothermal titration calorimetry [AID545994, Type: Literature]
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41
[SID144207112]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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42
[SID144207112]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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43
[SID50125767]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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44
[SID50125767]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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45
[SID144207112]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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46
[SID144207112]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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47
[SID144207112]
Ratio Potency (uM) qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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48
[SID144207112]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cells [AID720674, Type: confirmatory]
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49
[SID144207112]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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50
[SID144207112]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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