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Uric Acid (CID 1175) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(79)
 
 
Inconclusive(1)
 
 
Unspecified(44)
 
 
Top Targets:
MFS(11)
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD GR(4)
 
 
GT1 Glycogen..(3)
 
 
BioAssay Types:
Confirmatory(54)
 
 
Literature(52)
 
 
 
 
 
Summary(15)
 
 
Screening(2)
 
 
BioActivity Types:
Potency(67)
 
 
IC50(6)
 
 
Ki(3)
 
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 128    Data Row: 129   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103209253]
Ki 4.34Inhibition of GDA by colorimetric assay [AID502390, Type: Literature]
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2
[SID46392403]
Kd 550Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Human Liver Glycogen Phosphorylase Complexed With Uric Acid, N-Acetyl- Beta-D-Glucopyranosylamine, And Cp-403,700 [gi:27065325]
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3
[SID46392403]
Kd 550Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Human Liver Glycogen Phosphorylase Complexed With Uric Acid, N-Acetyl- Beta-D-Glucopyranosylamine, And Cp-403,700 [gi:27065325]
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4
[SID103209253]
Reducing activity to scavenge 10 uM 1, 1-diphenylpicrylhydrazyl (DPPH) [AID230361, Type: Literature]
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5
[SID46392403]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Human Liver Glycogen Phosphorylase Complexed With Uric Acid, N-Acetyl- Beta-D-Glucopyranosylamine, And Cp-403,700 [gi:27065325]
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6
[SID103209253]
IC50 60Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453745, Type: Literature]
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7
[SID103209253]
IC50 96Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453743, Type: Literature]
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8
[SID103209253]
IC50 100Inhibition of N-terminal His6-tagged Trypanosoma brucei CTPS assessed as NH3-dependent CTP formation by continuous spectrophotometric assay [AID613867, Type: Literature]
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9
[SID103209253]
IC50 101Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in TAPS buffer at pH 8.5 by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453746, Type: Literature]
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10
[SID103209253]
IC50 113Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation in Hepes buffer at pH 8 by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453742, Type: Literature]
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11
[SID103209253]
Ki 275TP_TRANSPORTER: inhibition of Estrone sulfate in Xenopus laevis oocytes [AID681040, Type: Literature]Solute carrier family 22 member 8 [gi:74730587]
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12
[SID103209253]
IC50 300Antioxidant activity against tert-butylhydroperoxide-induced lipid peroxidation in rat liver microsomes after 20 mins by TBARS method [AID1058625, Type: Literature]
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13
[SID103209253]
Km 947TP_TRANSPORTER: uptake in OAT1-expressing S2 cells [AID679379, Type: Literature]Solute carrier family 22 member 6 [gi:74762955]
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14
[SID103209253]
TP_TRANSPORTER: trans-stimulation in Xenopus laevis oocytes [AID678813, Type: Literature]Solute carrier family 22 member 8 [gi:74730587]
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15
[SID103209253]
TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID678986, Type: Literature]Solute carrier family 22 member 8 [gi:74730587]
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16
[SID103209253]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681141, Type: Literature]Solute carrier family 22 member 8 [gi:74730587]
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17
[SID103209253]
TP_TRANSPORTER: inhibition of PAH uptake (PAH: 2 uM, Urate: 2000 uM) in Xenopus laevis oocytes [AID679517, Type: Literature]Solute carrier family 22 member 6 [gi:74762955]
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18
[SID103209253]
TP_TRANSPORTER: inhibition of PAH uptake (PAH: 1 uM, Urate: 100 uM) in Xenopus laevis oocytes [AID679521, Type: Literature]Solute carrier family 22 member 6 [gi:74762955]
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19
[SID103209253]
TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679373, Type: Literature]Solute carrier family 22 member 6 [gi:74762955]
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20
[SID103209253]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681362, Type: Literature]Solute carrier family 22 member 6 [gi:81886651]
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