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2-(2,6-diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione (CID 11723708) - Compound BioActivity Data
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BioActivity Outcomes:
Active(42)
 
 
Inactive(25)
 
 
Inconclusive(31)
 
 
Unspecified(22)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
NR LBD Fxr(4)
 
 
 
 
NR LBD GR(4)
 
 
 
BioAssay Types:
Confirmatory(62)
 
 
 
 
Literature(31)
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(80)
 
 
 
 
IC50(10)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 119    Data Row: 120   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144210948]
Potency-Replicate_1 0.3857qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID103297541]
IC50 0.53Inhibition of IL-1-alpha-induced NF-kappaB activation in HeLa cells assessed as blocking of p50/p65 nuclear translocation [AID309667, Type: Literature]
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3
[SID103297541]
IC50 0.53Inhibition of NF-kappaB activation [AID448438, Type: Literature]
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4
[SID144210948]
Ratio Potency (uM) 0.571044qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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5
[SID144210948]
Potency-Replicate_1 1.2197qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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6
[SID144210948]
Potency-Replicate_1 1.5355qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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7
[SID144210948]
Ratio Potency (uM) 1.72289qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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8
[SID144210948]
Potency-Replicate_1 1.7374qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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9
[SID144210948]
Ratio Potency (uM) 2.08733qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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10
[SID144210948]
TR Potency (uM) 4.67296qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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11
[SID144210948]
Potency-Replicate_1 4.8558qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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12
[SID103297541]
IC50 5.35Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition by MTS assay [AID1057530, Type: Literature]
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13
[SID103297541]
IC50 5.74Antiproliferative activity against human DU145 cells assessed as growth inhibition by MTS assay [AID1057531, Type: Literature]
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14
[SID103297541]
IC50 6.9Inhibition of tubulin polymerization in porcine brain [AID270728, Type: Literature]Tubulin alpha-1A chain [gi:135435]
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15
[SID103297541]
IC50 6.9Inhibition of tubulin polymerization in porcine brain [AID270728, Type: Literature]Tubulin beta chain [gi:135490]
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16
[SID144210948]
Potency-Replicate_1 7.6959qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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17
[SID103297541]
IC50 8.3Antiproliferative activity against human PC3 cells assessed as growth inhibition by MTS assay [AID1057532, Type: Literature]
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18
[SID144210948]
Potency-Replicate_1 8.6349qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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19
[SID144210948]
Potency-Replicate_1 8.6349qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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20
[SID144210948]
Potency-Replicate_1 9.6885qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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