SureCN412218 (CID 11717091) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1)
 
 
Inactive(1)
 
 
Inconclusive(2)
 
 
Unspecified(454)
 
 
Top Targets:
PKc(49)
 
 
 
PKc like(40)
 
 
STKc AGC(28)
 
 
PTKc Abl(16)
 
 
PTKc EGFR(10)
 
 
BioAssay Types:
Confirmatory(3)
 
 
 
Literature(1)
 
 
BioActivity Types:
Potency(3)
 
 
 
IC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 458    Data Row: 458   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103483604]
IC50 0.032Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assay [AID262766, Type: Literature]TGF-beta receptor type-1 [gi:547777]
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2
[SID103483604]
IC50 0.032Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assay [AID262766, Type: Literature]TGF-beta receptor type-1 [gi:547777]
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3
[SID103483604]
 GSK_PKIS: TTK mean inhibition at 1 uM [Nanosyn] [AID651337, Type: other]Dual specificity protein kinase TTK [gi:160112977]
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4
[SID103483604]
 GSK_PKIS: TTK mean inhibition at 1 uM [Nanosyn] [AID651337, Type: other]Dual specificity protein kinase TTK [gi:160112977]
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5
[SID103483604]
 GSK_PKIS: TTK mean inhibition at 0.1 uM [Nanosyn] [AID651242, Type: other]Dual specificity protein kinase TTK [gi:160112977]
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6
[SID103483604]
 GSK_PKIS: TTK mean inhibition at 0.1 uM [Nanosyn] [AID651242, Type: other]Dual specificity protein kinase TTK [gi:160112977]
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7
[SID103483604]
 GSK_PKIS: TXK mean inhibition at 0.1 uM [Nanosyn] [AID651334, Type: other]Tyrosine-protein kinase TXK [gi:116242835]
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8
[SID103483604]
 GSK_PKIS: TXK mean inhibition at 0.1 uM [Nanosyn] [AID651334, Type: other]Tyrosine-protein kinase TXK [gi:116242835]
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9
[SID103483604]
 GSK_PKIS: TXK mean inhibition at 1 uM [Nanosyn] [AID651335, Type: other]Tyrosine-protein kinase TXK [gi:116242835]
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10
[SID103483604]
 GSK_PKIS: TXK mean inhibition at 1 uM [Nanosyn] [AID651335, Type: other]Tyrosine-protein kinase TXK [gi:116242835]
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11
[SID103483604]
 GSK_PKIS: TYK2 mean inhibition at 0.1 uM [Nanosyn] [AID651336, Type: other]Non-receptor tyrosine-protein kinase TYK [gi:56405328]
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12
[SID103483604]
 GSK_PKIS: TYK2 mean inhibition at 0.1 uM [Nanosyn] [AID651336, Type: other]Non-receptor tyrosine-protein kinase TYK [gi:56405328]
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13
[SID103483604]
 GSK_PKIS: TYK2 mean inhibition at 0.1 uM [Nanosyn] [AID651336, Type: other]Non-receptor tyrosine-protein kinase TYK [gi:56405328]
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14
[SID103483604]
 GSK_PKIS: TYK2 mean inhibition at 1 uM [Nanosyn] [AID651447, Type: other]Non-receptor tyrosine-protein kinase TYK [gi:56405328]
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15
[SID103483604]
 GSK_PKIS: TYK2 mean inhibition at 1 uM [Nanosyn] [AID651447, Type: other]Non-receptor tyrosine-protein kinase TYK [gi:56405328]
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16
[SID103483604]
 GSK_PKIS: TYK2 mean inhibition at 1 uM [Nanosyn] [AID651447, Type: other]Non-receptor tyrosine-protein kinase TYK [gi:56405328]
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17
[SID103483604]
 GSK_PKIS: TYRO3 mean inhibition at 0.1 uM [Nanosyn] [AID651448, Type: other]Tyrosine-protein kinase receptor TYRO3 [gi:1717829]
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18
[SID103483604]
 GSK_PKIS: TYRO3 mean inhibition at 0.1 uM [Nanosyn] [AID651448, Type: other]Tyrosine-protein kinase receptor TYRO3 [gi:1717829]
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19
[SID103483604]
 GSK_PKIS: TYRO3 mean inhibition at 1 uM [Nanosyn] [AID651449, Type: other]Tyrosine-protein kinase receptor TYRO3 [gi:1717829]
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20
[SID103483604]
 GSK_PKIS: TYRO3 mean inhibition at 1 uM [Nanosyn] [AID651449, Type: other]Tyrosine-protein kinase receptor TYRO3 [gi:1717829]
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21
[SID103483604]
 GSK_PKIS: YES mean inhibition at 0.1 uM [Nanosyn] [AID651450, Type: other]Tyrosine-protein kinase Yes [gi:125870]
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22
[SID103483604]
 GSK_PKIS: YES mean inhibition at 0.1 uM [Nanosyn] [AID651450, Type: other]Tyrosine-protein kinase Yes [gi:125870]
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23
[SID103483604]
 GSK_PKIS: YES mean inhibition at 1 uM [Nanosyn] [AID651451, Type: other]Tyrosine-protein kinase Yes [gi:125870]
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24
[SID103483604]
 GSK_PKIS: YES mean inhibition at 1 uM [Nanosyn] [AID651451, Type: other]Tyrosine-protein kinase Yes [gi:125870]
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25
[SID103483604]
 GSK_PKIS: ZAP70 mean inhibition at 0.1 uM [Nanosyn] [AID651452, Type: other]Tyrosine-protein kinase ZAP-70 [gi:1177044]
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26
[SID103483604]
 GSK_PKIS: ZAP70 mean inhibition at 0.1 uM [Nanosyn] [AID651452, Type: other]Tyrosine-protein kinase ZAP-70 [gi:1177044]
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27
[SID103483604]
 GSK_PKIS: ZAP70 mean inhibition at 1 uM [Nanosyn] [AID651453, Type: other]Tyrosine-protein kinase ZAP-70 [gi:1177044]
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28
[SID103483604]
 GSK_PKIS: ZAP70 mean inhibition at 1 uM [Nanosyn] [AID651453, Type: other]Tyrosine-protein kinase ZAP-70 [gi:1177044]
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29
[SID103483604]
 GSK_PKIS: MAPKAPK3 mean inhibition at 0.1 uM [Nanosyn] [AID651114, Type: other]MAP kinase-activated protein kinase 3 [gi:74762148]
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30
[SID103483604]
 GSK_PKIS: MAPKAPK3 mean inhibition at 1 uM [Nanosyn] [AID651115, Type: other]MAP kinase-activated protein kinase 3 [gi:74762148]
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31
[SID103483604]
 GSK_PKIS: DYRK2 mean inhibition at 0.1 uM [Nanosyn] [AID651184, Type: other]Dual specificity tyrosine-phosphorylation-regulated kinase [gi:148887370]
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32
[SID103483604]
 GSK_PKIS: DYRK2 mean inhibition at 1 uM [Nanosyn] [AID651185, Type: other]Dual specificity tyrosine-phosphorylation-regulated kinase [gi:148887370]
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33
[SID103483604]
 GSK_PKIS: MRCKA mean inhibition at 0.1 uM [Nanosyn] [AID651028, Type: other]Serine/threonine-protein kinase MRCK alpha [gi:74746874]
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34
[SID103483604]
 GSK_PKIS: MRCKA mean inhibition at 0.1 uM [Nanosyn] [AID651028, Type: other]Serine/threonine-protein kinase MRCK alpha [gi:74746874]
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35
[SID103483604]
 GSK_PKIS: MRCKA mean inhibition at 1 uM [Nanosyn] [AID651029, Type: other]Serine/threonine-protein kinase MRCK alpha [gi:74746874]
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36
[SID103483604]
 GSK_PKIS: MRCKA mean inhibition at 1 uM [Nanosyn] [AID651029, Type: other]Serine/threonine-protein kinase MRCK alpha [gi:74746874]
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37
[SID103483604]
 GSK_PKIS: PRAK mean inhibition at 0.1 uM [Nanosyn] [AID651142, Type: other]MAP kinase-activated protein kinase 5 [gi:52000829]
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38
[SID103483604]
 GSK_PKIS: PRAK mean inhibition at 0.1 uM [Nanosyn] [AID651142, Type: other]MAP kinase-activated protein kinase 5 [gi:52000829]
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39
[SID103483604]
 GSK_PKIS: PRAK mean inhibition at 1 uM [Nanosyn] [AID651143, Type: other]MAP kinase-activated protein kinase 5 [gi:52000829]
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40
[SID103483604]
 GSK_PKIS: PRAK mean inhibition at 1 uM [Nanosyn] [AID651143, Type: other]MAP kinase-activated protein kinase 5 [gi:52000829]
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41
[SID103483604]
 GSK_PKIS: MKNK1 mean inhibition at 0.1 uM [Nanosyn] [AID651124, Type: other]MAP kinase-interacting serine/threonine-protein kinase 1 [gi:30316115]
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42
[SID103483604]
 GSK_PKIS: MKNK1 mean inhibition at 1 uM [Nanosyn] [AID651125, Type: other]MAP kinase-interacting serine/threonine-protein kinase 1 [gi:30316115]
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43
[SID103483604]
 GSK_PKIS: TNK1 mean inhibition at 0.1 uM [Nanosyn] [AID651324, Type: other]Non-receptor tyrosine-protein kinase TNK1 [gi:116242821]
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44
[SID103483604]
 GSK_PKIS: TNK1 mean inhibition at 0.1 uM [Nanosyn] [AID651324, Type: other]Non-receptor tyrosine-protein kinase TNK1 [gi:116242821]
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45
[SID103483604]
 GSK_PKIS: TNK1 mean inhibition at 1 uM [Nanosyn] [AID651325, Type: other]Non-receptor tyrosine-protein kinase TNK1 [gi:116242821]
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46
[SID103483604]
 GSK_PKIS: TNK1 mean inhibition at 1 uM [Nanosyn] [AID651325, Type: other]Non-receptor tyrosine-protein kinase TNK1 [gi:116242821]
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47
[SID103483604]
 GSK_PKIS: SPHK1 mean inhibition at 0.1 uM [Nanosyn] [AID651218, Type: other]Sphingosine kinase 1 [gi:17369329]
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48
[SID103483604]
 GSK_PKIS: SPHK1 mean inhibition at 1 uM [Nanosyn] [AID651219, Type: other]Sphingosine kinase 1 [gi:17369329]
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49
[SID103483604]
 GSK_PKIS: MSK2 mean inhibition at 0.1 uM [Nanosyn] [AID651034, Type: other]Ribosomal protein S6 kinase alpha-4 [gi:37999483]
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50
[SID103483604]
 GSK_PKIS: MSK2 mean inhibition at 0.1 uM [Nanosyn] [AID651034, Type: other]Ribosomal protein S6 kinase alpha-4 [gi:37999483]
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