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GW682841X (CID 11717091) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(3)
 
 
Inconclusive(2)
 
 
Unspecified(456)
 
 
Top Targets:
PKc(43)
 
 
 
PKc like(42)
 
 
STKc AGC(16)
 
 
PTKc Abl(16)
 
 
PTKc Src like(11)
 
 
 
BioAssay Types:
Confirmatory(5)
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(6)
 
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 463    Data Row: 463   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103483604]
IC50 0.032Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assay [AID262766, Type: Literature]TGF-beta receptor type-1 [gi:547777]
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2
[SID124349940]
Potency 23.1881qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen [AID686947, Type: Literature]tyrosine-protein kinase Yes [Homo sapiens] [gi:4885661]
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3
[SID103483604]
GSK_PKIS: PRKG1 mean inhibition at 0.1 uM [Nanosyn] [AID651062, Type: other]cGMP-dependent protein kinase 1 [gi:6225588]
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4
[SID103483604]
GSK_PKIS: PRKG1 mean inhibition at 1 uM [Nanosyn] [AID651063, Type: other]cGMP-dependent protein kinase 1 [gi:6225588]
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5
[SID103483604]
GSK_PKIS: PRKG2 mean inhibition at 0.1 uM [Nanosyn] [AID651064, Type: other]cGMP-dependent protein kinase 2 [gi:6226833]
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6
[SID103483604]
GSK_PKIS: PRKG2 mean inhibition at 1 uM [Nanosyn] [AID651065, Type: other]cGMP-dependent protein kinase 2 [gi:6226833]
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7
[SID103483604]
GSK_PKIS: CHEK2 mean inhibition at 0.1 uM [Nanosyn] [AID651106, Type: other]Serine/threonine-protein kinase Chk2 [gi:6685284]
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8
[SID103483604]
GSK_PKIS: CHEK2 mean inhibition at 1 uM [Nanosyn] [AID651107, Type: other]Serine/threonine-protein kinase Chk2 [gi:6685284]
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9
[SID103483604]
GSK_PKIS: P38delta mean inhibition at 0.1 uM [Nanosyn] [AID651206, Type: other]Mitogen-activated protein kinase 13 [gi:6685642]
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10
[SID103483604]
GSK_PKIS: P38delta mean inhibition at 1 uM [Nanosyn] [AID651207, Type: other]Mitogen-activated protein kinase 13 [gi:6685642]
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11
[SID103483604]
GSK_PKIS: BRK mean inhibition at 0.1 uM [Nanosyn] [AID651394, Type: other]Protein-tyrosine kinase 6 [gi:8928302]
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12
[SID103483604]
GSK_PKIS: BRK mean inhibition at 1 uM [Nanosyn] [AID651395, Type: other]Protein-tyrosine kinase 6 [gi:8928302]
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13
[SID103483604]
GSK_PKIS: KDR mean inhibition at 0.1 uM [Nanosyn] [AID651266, Type: other]Vascular endothelial growth factor receptor 2 [gi:9087218]
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14
[SID103483604]
GSK_PKIS: KDR mean inhibition at 1 uM [Nanosyn] [AID651267, Type: other]Vascular endothelial growth factor receptor 2 [gi:9087218]
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15
[SID103483604]
GSK_PKIS: DYRK1B mean inhibition at 0.1 uM [Nanosyn] [AID651182, Type: other]Dual specificity tyrosine-phosphorylation-regulated kinase 1B [gi:9296963]
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16
[SID103483604]
GSK_PKIS: DYRK1B mean inhibition at 1 uM [Nanosyn] [AID651183, Type: other]Dual specificity tyrosine-phosphorylation-regulated kinase 1B [gi:9296963]
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17
[SID103483604]
GSK_PKIS: RSK4 mean inhibition at 0.1 uM [Nanosyn] [AID651078, Type: other]Ribosomal protein S6 kinase alpha-6 [gi:11133131]
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18
[SID103483604]
GSK_PKIS: RSK4 mean inhibition at 1 uM [Nanosyn] [AID651079, Type: other]Ribosomal protein S6 kinase alpha-6 [gi:11133131]
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19
[SID103483604]
GSK_PKIS: PRKD3 mean inhibition at 0.1 uM [Nanosyn] [AID651060, Type: other]Serine/threonine-protein kinase D3 [gi:12230239]
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20
[SID103483604]
GSK_PKIS: PRKD3 mean inhibition at 1 uM [Nanosyn] [AID651061, Type: other]Serine/threonine-protein kinase D3 [gi:12230239]
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21
[SID103483604]
GSK_PKIS: PAK5 mean inhibition at 0.1 uM [Nanosyn] [AID651366, Type: other]Serine/threonine-protein kinase PAK 7 [gi:12585290]
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22
[SID103483604]
GSK_PKIS: PAK5 mean inhibition at 1 uM [Nanosyn] [AID651367, Type: other]Serine/threonine-protein kinase PAK 7 [gi:12585290]
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23
[SID103483604]
GSK_PKIS: LOK mean inhibition at 0.1 uM [Nanosyn] [AID651344, Type: other]Serine/threonine-protein kinase 10 [gi:12643358]
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24
[SID103483604]
GSK_PKIS: LOK mean inhibition at 1 uM [Nanosyn] [AID651345, Type: other]Serine/threonine-protein kinase 10 [gi:12643358]
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25
[SID103483604]
GSK_PKIS: JAK2 mean inhibition at 0.1 uM [Nanosyn] [AID651262, Type: other]Tyrosine-protein kinase JAK2 [gi:12643404]
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26
[SID103483604]
GSK_PKIS: JAK2 mean inhibition at 1 uM [Nanosyn] [AID651263, Type: other]Tyrosine-protein kinase JAK2 [gi:12643404]
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27
[SID103483604]
GSK_PKIS: AKT3 mean inhibition at 0.1 uM [Nanosyn] [AID651022, Type: other]RAC-gamma serine/threonine-protein kinase [gi:12643943]
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28
[SID103483604]
GSK_PKIS: AKT3 mean inhibition at 1 uM [Nanosyn] [AID651023, Type: other]RAC-gamma serine/threonine-protein kinase [gi:12643943]
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29
[SID103483604]
GSK_PKIS: IRR mean inhibition at 0.1 uM [Nanosyn] [AID651256, Type: other]Insulin receptor-related protein [gi:12644000]
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30
[SID103483604]
GSK_PKIS: IRR mean inhibition at 1 uM [Nanosyn] [AID651257, Type: other]Insulin receptor-related protein [gi:12644000]
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31
[SID103483604]
GSK_PKIS: GSK3A mean inhibition at 0.1 uM [Nanosyn] [AID651186, Type: other]Glycogen synthase kinase-3 alpha [gi:12644292]
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32
[SID103483604]
GSK_PKIS: GSK3A mean inhibition at 1 uM [Nanosyn] [AID651187, Type: other]Glycogen synthase kinase-3 alpha [gi:12644292]
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33
[SID103483604]
GSK_PKIS: MST1 mean inhibition at 0.1 uM [Nanosyn] [AID651354, Type: other]Serine/threonine-protein kinase 4 [gi:13124559]
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34
[SID103483604]
GSK_PKIS: MST1 mean inhibition at 1 uM [Nanosyn] [AID651355, Type: other]Serine/threonine-protein kinase 4 [gi:13124559]
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35
[SID103483604]
GSK_PKIS: FGFR4 mean inhibition at 0.1 uM [Nanosyn] [AID651438, Type: other]Fibroblast growth factor receptor 4 [gi:13432140]
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36
[SID103483604]
GSK_PKIS: FGFR4 mean inhibition at 1 uM [Nanosyn] [AID651439, Type: other]Fibroblast growth factor receptor 4 [gi:13432140]
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37
[SID103483604]
GSK_PKIS: IKKB mean inhibition at 0.1 uM [Nanosyn] [AID651226, Type: other]Inhibitor of nuclear factor kappa-B kinase subunit beta [gi:14285497]
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38
[SID103483604]
GSK_PKIS: IKKB mean inhibition at 1 uM [Nanosyn] [AID651227, Type: other]Inhibitor of nuclear factor kappa-B kinase subunit beta [gi:14285497]
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39
[SID103483604]
GSK_PKIS: IKK-beta % inhibition at 1 uM [UNC Frye lab] [AID651542, Type: other]Inhibitor of nuclear factor kappa-B kinase subunit beta [gi:14285497]
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40
[SID103483604]
GSK_PKIS: ARK5 mean inhibition at 0.1 uM [Nanosyn] [AID651090, Type: other]NUAK family SNF1-like kinase 1 [gi:14424095]
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41
[SID103483604]
GSK_PKIS: ARK5 mean inhibition at 1 uM [Nanosyn] [AID651091, Type: other]NUAK family SNF1-like kinase 1 [gi:14424095]
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42
[SID103483604]
GSK_PKIS: IKKE mean inhibition at 0.1 uM [Nanosyn] [AID651228, Type: other]Inhibitor of nuclear factor kappa-B kinase subunit epsilon [gi:14548079]
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43
[SID103483604]
GSK_PKIS: IKKE mean inhibition at 1 uM [Nanosyn] [AID651229, Type: other]Inhibitor of nuclear factor kappa-B kinase subunit epsilon [gi:14548079]
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44
[SID103483604]
GSK_PKIS: IKK-epsilon % inhibition at 1 uM [UNC Frye lab] [AID651543, Type: other]Inhibitor of nuclear factor kappa-B kinase subunit epsilon [gi:14548079]
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45
[SID103483604]
GSK_PKIS: SPHK1 mean inhibition at 0.1 uM [Nanosyn] [AID651218, Type: other]Sphingosine kinase 1 [gi:17369329]
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46
[SID103483604]
GSK_PKIS: SPHK1 mean inhibition at 1 uM [Nanosyn] [AID651219, Type: other]Sphingosine kinase 1 [gi:17369329]
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47
[SID103483604]
GSK_PKIS: CK1-g1 mean inhibition at 0.1 uM [Nanosyn] [AID651156, Type: other]Casein kinase I isoform gamma-1 [gi:18202957]
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48
[SID103483604]
GSK_PKIS: CK1-g1 mean inhibition at 1 uM [Nanosyn] [AID651157, Type: other]Casein kinase I isoform gamma-1 [gi:18202957]
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49
[SID103483604]
GSK_PKIS: EPHB4 mean inhibition at 0.1 uM [Nanosyn] [AID651422, Type: other]Ephrin type-B receptor 4 [gi:19860819]
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50
[SID103483604]
GSK_PKIS: EPHB4 mean inhibition at 1 uM [Nanosyn] [AID651423, Type: other]Ephrin type-B receptor 4 [gi:19860819]
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