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protoapigenone (CID 11644907) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(134)
 
 
Inactive(619)
 
 
Inconclusive(42)
 
 
Unspecified(8)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(21)
 
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
Tryp SPc(8)
 
 
 
BioAssay Types:
Screening(515)
 
 
 
 
Confirmatory(244)
 
 
 
 
 
Literature(28)
 
 
 
 
BioActivity Types:
Potency(157)
 
 
 
 
 
IC50(63)
 
 
 
 
AC50(14)
 
 
 
 
EC50(13)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 740    Data Row: 803   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID22405515]
Potency 0.3663qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID22405515]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID103525477]
IC50 0.71Antitumor activity against human SKOV3 cells assessed as cell proliferation after 24 hrs by MTT assay [AID597750, Type: Literature]
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4
[SID103525477]
IC50 1.43Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method [AID296683, Type: Literature]
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5
[SID22405515]
Potency 1.4581A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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6
[SID22405515]
IC50_Mean 1.62Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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7
[SID103525477]
IC50 1.7Antitumor activity against human MDA-MB-231 cells assessed as cell proliferation after 24 hrs by MTT assay [AID597749, Type: Literature]
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8
[SID22405515]
EC50 1.842Dose Response Cell-based Assay for Inhibitors of Wee1 Degradation [AID1412, Type: confirmatory]WEE1 homolog (S. pombe) [Homo sapiens] [gi:47123300]
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9
[SID22405515]
EC50 1.842Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation [AID1414, Type: confirmatory]cyclin B1 [Homo sapiens] [gi:119571691]
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10
[SID22405515]
IC50_Mean 2.21Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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11
[SID103525477]
IC50 2.27Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method [AID296682, Type: Literature]
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12
[SID22405515]
Absolute IC50 (CHOP) 2.58CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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13
[SID22405515]
CC50 2.605A Cell Based Secondary Assay to Explore Cytotoxicity in THP-1 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID489025, Type: confirmatory]
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14
[SID22405515]
IC50 2.61Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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15
[SID22405515]
Potency 2.8184VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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16
[SID22405515]
IC50 3.02A Cell Based Secondary Assay to Explore Compounds that Modulate Non-Replicating, Drug-tolerant Compounds in Replicating H37Rv TB of Mycobacterium tuberculosis [AID492952, Type: confirmatory]
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17
[SID22405515]
Potency 3.1623qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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18
[SID22405515]
Potency 3.2643qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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19
[SID22405515]
CC50 3.28A Cell Based Secondary Assay to Explore Cytotoxicity in Vero E6 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID492998, Type: confirmatory]
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20
[SID103525477]
IC50 3.74Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method [AID296684, Type: Literature]
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21
[SID22405515]
Absolute IC50 (XBP1) 3.84XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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22
[SID22405515]
IC50 3.874High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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23
[SID103525477]
IC50 3.93Antitumor activity against human RPMI8226 cells assessed as cell proliferation after 24 hrs by MTT assay [AID597807, Type: Literature]
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24
[SID22405515]
Potency 3.9811qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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25
[SID22405515]
Potency 4.1095A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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26
[SID22405515]
EC50 4.281Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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27
[SID22405515]
AC50_uM 4.47Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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28
[SID22405515]
AC50_uM 5.12Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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29
[SID22405515]
AC50_uM 5.13HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Antagonist_Dose_CherryPick_Activity [AID743446, Type: confirmatory]
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30
[SID103525477]
IC50 5.5Antitumor activity against human MCF7 cells assessed as cell proliferation after 24 hrs by MTT assay [AID597748, Type: Literature]
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31
[SID22405515]
CC50 5.735A Cell Based Secondary Assay to Explore Cytotoxicity in HepG2 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID489018, Type: confirmatory]
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32
[SID22405515]
IC50_Mean 5.903Concentration-Response Confirmation Assays for HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules [AID463136, Type: confirmatory]
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33
[SID103525477]
IC50 6.13Antitumor activity against human PC3 cells assessed as cell proliferation after 24 hrs by MTT assay [AID597751, Type: Literature]
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34
[SID22405515]
Potency 6.3096qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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35
[SID22405515]
AC50_uM 6.31A549 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-06_Antagonist_Dose_CherryPick_Activity [AID743412, Type: confirmatory]
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36
[SID103525477]
IC50 6.79Cytotoxicity against human HEK293 cells assessed as cell proliferation after 24 hrs by MTT assay [AID597809, Type: Literature]
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37
[SID22405515]
AC50_uM 7.09HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Antagonist_Dose_CherryPick_Activity [AID743416, Type: confirmatory]
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38
[SID22405515]
Potency 7.3078qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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39
[SID22405515]
Potency 7.3078qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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40
[SID103525477]
IC50 7.66Antitumor activity against human U266 cells assessed as cell proliferation after 24 hrs by MTT assay [AID597808, Type: Literature]
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41
[SID103525477]
IC50 7.77Antitumor activity against human HepG2 cells assessed as cell proliferation after 24 hrs by MTT assay [AID597752, Type: Literature]
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42
[SID22405515]
Potency 7.8976qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen [AID651813, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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43
[SID103525477]
IC50 8.11Cytotoxicity against human PBMC assessed as cell proliferation after 24 hrs by MTT assay [AID597810, Type: Literature]
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44
[SID103525477]
IC50 8.11Cytotoxicity against human HepG2 cells after 72 hrs by MTT colorimetric method [AID296681, Type: Literature]
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45
[SID22405515]
AbsAC35_uM 8.15HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Other_Dose_CherryPick_Activity_Set2 [AID743395, Type: confirmatory]
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46
[SID22405515]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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47
[SID22405515]
IC50_Mean 10.101Identify inhibitors of Caspase inhibitor (zVAD) Induced Cell Death in L929 Cells: Concentration-response Confirmation Assays [AID463181, Type: confirmatory]
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48
[SID22405515]
Potency 11.2202qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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49
[SID22405515]
Potency 11.2202qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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50
[SID22405515]
Potency 12.5893qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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