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protoapigenone (CID 11644907) - Compound BioActivity Data
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BioActivity Outcomes:
Active(134)
 
 
Inactive(625)
 
 
Inconclusive(42)
 
 
Unspecified(8)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(21)
 
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
Tryp SPc(8)
 
 
 
BioAssay Types:
Screening(515)
 
 
 
 
Confirmatory(244)
 
 
 
 
 
Literature(34)
 
 
 
 
BioActivity Types:
Potency(157)
 
 
 
 
 
IC50(63)
 
 
 
 
AC50(14)
 
 
 
 
EC50(13)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 740    Data Row: 809   Total Pages: 41   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID22405515]
Potency 0.3663qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID22405515]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID103525477]
IC50 0.71Antitumor activity against human SKOV3 cells assessed as cell proliferation after 24 hrs by MTT assay [AID597750, Type: Literature]
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4
[SID103525477]
IC50 1.43Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method [AID296683, Type: Literature]
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5
[SID22405515]
Potency 1.4581A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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6
[SID22405515]
IC50_Mean 1.62Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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7
[SID103525477]
IC50 1.7Antitumor activity against human MDA-MB-231 cells assessed as cell proliferation after 24 hrs by MTT assay [AID597749, Type: Literature]
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8
[SID22405515]
EC50 1.842Dose Response Cell-based Assay for Inhibitors of Wee1 Degradation [AID1412, Type: confirmatory]WEE1 homolog (S. pombe) [Homo sapiens] [gi:47123300]
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9
[SID22405515]
EC50 1.842Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation [AID1414, Type: confirmatory]cyclin B1 [Homo sapiens] [gi:119571691]
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10
[SID22405515]
IC50_Mean 2.21Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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11
[SID103525477]
IC50 2.27Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method [AID296682, Type: Literature]
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12
[SID22405515]
Absolute IC50 (CHOP) 2.58CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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13
[SID22405515]
CC50 2.605A Cell Based Secondary Assay to Explore Cytotoxicity in THP-1 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID489025, Type: confirmatory]
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14
[SID22405515]
IC50 2.61Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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15
[SID22405515]
Potency 2.8184VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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16
[SID22405515]
IC50 3.02A Cell Based Secondary Assay to Explore Compounds that Modulate Non-Replicating, Drug-tolerant Compounds in Replicating H37Rv TB of Mycobacterium tuberculosis [AID492952, Type: confirmatory]
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17
[SID22405515]
Potency 3.1623qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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18
[SID22405515]
Potency 3.2643qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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19
[SID22405515]
CC50 3.28A Cell Based Secondary Assay to Explore Cytotoxicity in Vero E6 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID492998, Type: confirmatory]
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20
[SID103525477]
IC50 3.74Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method [AID296684, Type: Literature]
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