5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione (CID 11630874) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(18)
 
 
Top Targets:
PI3Kc IB gamm..(2)
 
 
Peptidase C19(2)
 
 
ChSh(1)
 
 
NR LBD VDR(1)
 
 
PI3Kc IA alph..(1)
 
 
BioAssay Types:
Literature(9)
 
 
Confirmatory(8)
 
 
BioActivity Types:
IC50(9)
 
 
Potency(8)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 18    Data Row: 18   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103492078]
IC50 0.02Inhibition of human CK2 [AID267038, Type: Literature]Casein kinase II subunit alpha' [gi:125266]
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2
[SID103492078]
IC50 0.02Inhibition of human CK2 [AID267038, Type: Literature]Casein kinase II subunit alpha' [gi:125266]
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3
[SID103492078]
IC50 0.03Inhibition of human PI3Kgamma [AID266953, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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4
[SID103492078]
IC50 0.03Inhibition of recombinant human PI3Kgamma by HTRF assay [AID630521, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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5
[SID103492078]
IC50 0.03Inhibition of human PI3Kgamma [AID266953, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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6
[SID103492078]
IC50 0.03Inhibition of recombinant human PI3Kgamma by HTRF assay [AID630521, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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7
[SID103492078]
IC50 0.23Inhibition of C5a-mediated PKB/Akt phosphorylation in mouse Raw264 macrophage [AID267040, Type: Literature]
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8
[SID103492078]
IC50 0.4Inhibition of MCP1-induced PKB/Akt phosphorylation in THP1 cells [AID267043, Type: Literature]
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9
[SID103492078]
IC50 0.94Inhibition of human PI3Kalpha [AID266954, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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10
[SID103492078]
IC50 0.94Inhibition of human PI3Kalpha [AID266954, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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11
[SID90340578]
Potency 4.6109qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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12
[SID103492078]
IC50 4.73Inhibition of SCF1-induced PKB/Akt phosphorylation in THP1 cells [AID267044, Type: Literature]
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13
[SID90340578]
Potency 12.5893Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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14
[SID90340578]
Potency 12.5893Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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15
[SID90340578]
Potency 12.5893Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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16
[SID90340578]
Potency 12.5893Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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17
[SID103492078]
IC50 20Inhibition of human PI3Kbeta [AID266956, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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18
[SID103492078]
IC50 20Inhibition of human PI3Kdelta [AID266957, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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19
[SID103492078]
IC50 20Inhibition of human PI3Kdelta [AID266957, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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20
[SID103492078]
IC50 20Inhibition of human PI3Kbeta [AID266956, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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21
[SID90340578]
Potency 21.1923Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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22
[SID90340578]
Potency 21.1923Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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23
[SID90340578]
Potency 21.1923Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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24
[SID90340578]
Potency 21.1923qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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25
[SID90340578]
Potency 26.6795qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1) [AID488816, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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26
[SID90340578]
Potency 39.8107qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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27
[SID90340578]
Potency 44.6684Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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28
[SID90340578]
Potency 52.6732Inhibitors of USP1/UAF1: Hit Validation in Primary Assay [AID540327, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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29
[SID99302785]
 A screen for compounds that inhibit liver stage malaria [AID624349, Type: other]
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