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BioActivity Data for Compound 5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione (CID 11630874)

BioActivity Outcomes:
Active(24)
 
 
Inactive(49)
 
 
Inconclusive(17)
 
 
Unspecified(112)
 
 
Top Targets:
CYCLIN(9)
 
 
7tm 4(5)
 
 
 
PIKKc TOR(4)
 
 
PI3Kc IB gamm..(4)
 
 
 
Pyr redox dim(4)
 
 
 
BioAssay Types:
Literature(127)
 
 
 
 
Confirmatory(70)
 
 
 
 
Screening(2)
 
 
BioAssay Categories:
In vivo(6)
 
 
Biochemical(112)
 
 
 
 
Toxicity(2)
 
 
 
ADME(10)
 
 
Cell-based(10)
 
 
 
 
BioActivity Types:
Potency(67)
 
 
 
 
IC50(18)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 176    Data Row: 202   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103492078]
IC50 0.02Inhibition of human CK2 [AID267038, Type: Literature]Casein kinase II subunit alpha' [gi:125266]
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2
[SID103492078]
IC50 0.02Inhibition of human CK2 [AID267038, Type: Literature]Casein kinase II subunit beta [gi:54037520]
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3
[SID103492078]
IC50 0.02Inhibition of human CK2 [AID267038, Type: Literature]Casein kinase II subunit alpha [gi:55977123]
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4
[SID103492078]
IC50 0.03Inhibition of human PI3Kgamma [AID266953, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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5
[SID103492078]
IC50 0.03Inhibition of PI3Kgamma (unknown origin) by lipid kinase assay [AID1120064, Type: confirmatory]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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6
[SID103492078]
IC50 0.03Inhibition of recombinant human PI3Kgamma by HTRF assay [AID630521, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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7
[SID103492078]
IC50 0.23Inhibition of C5a-mediated PKB/Akt phosphorylation in mouse Raw264 macrophage [AID267040, Type: Literature]
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8
[SID103492078]
IC50 0.4Inhibition of MCP1-induced PKB/Akt phosphorylation in THP1 cells [AID267043, Type: Literature]
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9
[SID103492078]
IC50 0.94Inhibition of PI3Kalpha (unknown origin) by lipid kinase assay [AID1120061, Type: confirmatory]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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10
[SID103492078]
IC50 0.94Inhibition of human PI3Kalpha [AID266954, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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11
[SID90340578]
Potency 4.6109qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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12
[SID103492078]
IC50 4.73Inhibition of SCF1-induced PKB/Akt phosphorylation in THP1 cells [AID267044, Type: Literature]
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13
[SID90340578]
Potency 12.5893Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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14
[SID103492078]
IC50 20Inhibition of PI3Kdelta (unknown origin) by lipid kinase assay [AID1120063, Type: confirmatory]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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15
[SID103492078]
IC50 20Inhibition of human PI3Kdelta [AID266957, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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16
[SID103492078]
IC50 20Inhibition of human PI3Kbeta [AID266956, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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17
[SID103492078]
IC50 20Inhibition of PI3Kbeta (unknown origin) by lipid kinase assay [AID1120062, Type: confirmatory]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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18
[SID90340578]
Potency 21.1923Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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19
[SID90340578]
Potency 21.1923qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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20
[SID90340578]
Potency 26.6795qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1) [AID488816, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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