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5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione (CID 11630874) - Compound BioActivity Data
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BioActivity Outcomes:
Active(20)
 
 
Inactive(48)
 
 
Inconclusive(17)
 
 
Unspecified(112)
 
 
Top Targets:
CYCLIN(9)
 
 
PKc like(7)
 
 
 
Pyr redox dim(4)
 
 
 
PIKKc TOR(4)
 
 
7TM GPCR Srx(4)
 
 
 
BioAssay Types:
Literature(129)
 
 
 
 
Confirmatory(65)
 
 
 
 
BioActivity Types:
Potency(66)
 
 
 
 
IC50(14)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 171    Data Row: 197   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103492078]
IC50 0.02Inhibition of human CK2 [AID267038, Type: Literature]Casein kinase II subunit alpha' [gi:125266]
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2
[SID103492078]
IC50 0.02Inhibition of human CK2 [AID267038, Type: Literature]Casein kinase II subunit beta [gi:54037520]
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3
[SID103492078]
IC50 0.02Inhibition of human CK2 [AID267038, Type: Literature]Casein kinase II subunit alpha [gi:55977123]
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4
[SID103492078]
IC50 0.03Inhibition of human PI3Kgamma [AID266953, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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5
[SID103492078]
IC50 0.03Inhibition of recombinant human PI3Kgamma by HTRF assay [AID630521, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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6
[SID103492078]
IC50 0.23Inhibition of C5a-mediated PKB/Akt phosphorylation in mouse Raw264 macrophage [AID267040, Type: Literature]
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7
[SID103492078]
IC50 0.4Inhibition of MCP1-induced PKB/Akt phosphorylation in THP1 cells [AID267043, Type: Literature]
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8
[SID103492078]
IC50 0.94Inhibition of human PI3Kalpha [AID266954, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [gi:126302584]
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9
[SID90340578]
Potency 4.6109qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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10
[SID103492078]
IC50 4.73Inhibition of SCF1-induced PKB/Akt phosphorylation in THP1 cells [AID267044, Type: Literature]
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11
[SID90340578]
Potency 12.5893Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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12
[SID103492078]
IC50 20Inhibition of human PI3Kdelta [AID266957, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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13
[SID103492078]
IC50 20Inhibition of human PI3Kbeta [AID266956, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [gi:1171955]
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14
[SID90340578]
Potency 21.1923Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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15
[SID90340578]
Potency 21.1923qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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16
[SID90340578]
Potency 26.6795qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1) [AID488816, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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17
[SID90340578]
Potency 39.8107qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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18
[SID90340578]
Potency 44.6684Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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19
[SID90340578]
Potency 52.6732Inhibitors of USP1/UAF1: Hit Validation in Primary Assay [AID540327, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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20
[SID99302785]
A screen for compounds that inhibit liver stage malaria [AID624349, Type: other]
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21
[SID103492078]
IC50 10Inhibition of human MKK7beta [AID267039, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 7 [gi:6831583]
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22
[SID103492078]
IC50 53Inhibition of MCP1-induced chemotaxis of THP1 cells [AID267045, Type: Literature]
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23
[SID103492078]
IC50 53Inhibition of MCP1-induced chemotaxis of mouse primary monocytes [AID267046, Type: Literature]
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24
[SID103492078]
Reduction of neutrophil recruitment in mouse at 10 mg/kg, po [AID267047, Type: Literature]
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25
[SID103492078]
Clearance in rat at 10 mg/kg, iv [AID267048, Type: Literature]
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26
[SID103492078]
AUC in rat at 10 mg/kg, iv [AID267049, Type: Literature]
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27
[SID103492078]
AUC in rat at 10 mg/kg, po [AID267050, Type: Literature]
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28
[SID103492078]
Cmax in rat at 10 mg/kg, iv [AID267051, Type: Literature]
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29
[SID103492078]
Cmax in rat at 10 mg/kg, po [AID267052, Type: Literature]
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30
[SID103492078]
Half life in rat at 10 mg/kg, iv [AID267053, Type: Literature]
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31
[SID103492078]
Half life in rat at 10 mg/kg, po [AID267054, Type: Literature]
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32
[SID103492078]
Volume of distribution in rat at 10 mg/kg, iv [AID267055, Type: Literature]
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33
[SID103492078]
Metabolism in rat microsome after 1 hr [AID267056, Type: Literature]
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34
[SID103492078]
Metabolism in human microsome after 1 hr [AID267057, Type: Literature]
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35
[SID103492078]
Dissociation constant, pKa of the compound [AID267058, Type: Literature]
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36
[SID103492078]
Residual activity at rat AMPK at 10 uM in presence of 10 uM ATP relative to control [AID266958, Type: Literature]
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37
[SID103492078]
Residual activity at yeast CK1 at 10 uM in presence of 10 uM ATP relative to control [AID266975, Type: Literature]
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38
[SID103492078]
Residual activity at human CDK2/CyclinA at 10 uM in presence of 10 uM ATP relative to control [AID266967, Type: Literature]Cyclin-dependent kinase 2 [gi:116051]
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39
[SID103492078]
Residual activity at human CDK2/CyclinE at 10 uM in presence of 10 uM ATP relative to control [AID266968, Type: Literature]Cyclin-dependent kinase 2 [gi:116051]
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40
[SID103492078]
Residual activity at human CDK1/CyclinB at 10 uM in presence of 10 uM ATP relative to control [AID266966, Type: Literature]G2/mitotic-specific cyclin-B1 [gi:116176]
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41
[SID103492078]
Residual activity at human MAPK1 at 10 uM in presence of 10 uM ATP relative to control [AID266995, Type: Literature]Mitogen-activated protein kinase 1 [gi:119554]
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42
[SID103492078]
Residual activity at human FGFR3 at 10 uM in presence of 10 uM ATP relative to control [AID266981, Type: Literature]Fibroblast growth factor receptor 3 [gi:120050]
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43
[SID103492078]
Residual activity at human IGF1R at 10 uM in presence of 10 uM ATP relative to control [AID266986, Type: Literature]Insulin-like growth factor 1 receptor [gi:124240]
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44
[SID103492078]
Residual activity at human PKA at 10 uM in presence of 10 uM ATP relative to control [AID267008, Type: Literature]cAMP-dependent protein kinase catalytic subunit alpha [gi:125205]
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45
[SID103492078]
Residual activity at human PKA at 10 uM in presence of 10 uM ATP relative to control [AID267008, Type: Literature]cAMP-dependent protein kinase catalytic subunit beta [gi:125210]
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46
[SID103492078]
Residual activity at human CK2 at 10 uM in presence of 10 uM ATP relative to control [AID266976, Type: Literature]Casein kinase II subunit alpha' [gi:125266]
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47
[SID103492078]
Residual activity at human Syk at 10 uM in presence of 10 uM ATP relative to control [AID267033, Type: Literature]Tyrosine-protein kinase SYK [gi:1174527]
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48
[SID103492078]
Residual activity at human ZAP70 at 10 uM in presence of 10 uM ATP relative to control [AID267036, Type: Literature]Tyrosine-protein kinase ZAP-70 [gi:1177044]
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49
[SID103492078]
Residual activity at human MAPKAPK2 at 10 uM in presence of 10 uM ATP relative to control [AID266996, Type: Literature]MAP kinase-activated protein kinase 2 [gi:1346538]
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50
[SID103492078]
Residual activity at human Bmx at 10 uM in presence of 10 uM ATP relative to control [AID266963, Type: Literature]Cytoplasmic tyrosine-protein kinase BMX [gi:1705489]
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