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crizotinib (CID 11626560) - Compound BioActivity Data
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BioActivity Outcomes:
Active(343)
 
 
Inactive(12)
 
 
Inconclusive(2)
 
 
Unspecified(1043)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
PTKc Abl(17)
 
 
STKc AGC(17)
 
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Literature(1021)
 
 
 
Confirmatory(15)
 
 
 
 
BioActivity Types:
Kd(442)
 
 
 
IC50(433)
 
 
 
Potency(16)
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1400    Data Row: 1400   Total Pages: 28   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103728028]
Kd 0.00055Binding constant for MET(M1250T) kinase domain [AID624795, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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2
[SID103728028]
IC50 0.00078Inhibition of recombinant MET using biotinylated-poly(GT) peptide as substrate after 60 mins [AID608694, Type: Literature]
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3
[SID103728028]
IC50 0.001Inhibition of c-MET [AID617232, Type: Literature]
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4
[SID103728028]
IC50 0.001Inhibition of ALK [AID617235, Type: Literature]
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5
[SID103728028]
IC50 0.001Inhibition of TRKA [AID617246, Type: Literature]
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6
[SID103728028]
IC50 0.001Inhibition of AXL [AID617240, Type: Literature]
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7
[SID103728028]
IC50 0.001Inhibition of LCK [AID617346, Type: Literature]
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8
[SID103728028]
Kd 0.0015Binding constant for MET(Y1235D) kinase domain [AID624796, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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9
[SID103728028]
IC50 0.0016Inhibition of c-Met incubated for 60 mins at spectrophotometry [AID678093, Type: Literature]
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10
[SID103728028]
IC50 0.002Inhibition of TRKB [AID617337, Type: Literature]
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11
[SID103728028]
Ki 0.002Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay [AID617229, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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12
[SID103728028]
Kd 0.0021Binding constant for MET kinase domain [AID624794, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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13
[SID103728028]
Kd 0.0033Binding constant for ALK kinase domain [AID624944, Type: Literature]ALK tyrosine kinase receptor [gi:296439447]
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14
[SID103728028]
Kd 0.0036Binding constant for MERTK kinase domain [AID624767, Type: Literature]Tyrosine-protein kinase Mer [gi:160332297]
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15
[SID103728028]
IC50 0.004Inhibition of human c-MET [AID614836, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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16
[SID103728028]
Kd 0.0041Binding constant for ROS1 kinase domain [AID624899, Type: Literature]Proto-oncogene tyrosine-protein kinase ROS [gi:126302596]
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17
[SID103728028]
IC50 0.005Inhibition of TIE2 [AID617243, Type: Literature]
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18
[SID103728028]
Kd 0.006Binding constant for EPHB6 kinase domain [AID624957, Type: Literature]Ephrin type-B receptor 6 [gi:294862532]
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19
[SID103728028]
Kd 0.0078Binding constant for AXL kinase domain [AID624840, Type: Literature]Tyrosine-protein kinase receptor UFO [gi:239938818]
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20
[SID103728028]
IC50 0.008Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method [AID617225, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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21
[SID103728028]
IC50 0.008Inhibition of c-Met [AID383065, Type: Literature]
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22
[SID103728028]
IC50 0.008Inhibition of recombinant c-Met by TR-FRET assay [AID460491, Type: Literature]
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23
[SID103728028]
IC50 0.01Cytotoxicity against human SU-DHL1 cells expressing ALK coexpressing NPM [AID642897, Type: Literature]
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24
[SID103728028]
Kd 0.01Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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25
[SID103728028]
Kd 0.012Binding constant for ABL1(T315I)-nonphosphorylated kinase domain [AID624988, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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26
[SID103728028]
Kd 0.012Binding constant for LTK kinase domain [AID624743, Type: Literature]Leukocyte tyrosine kinase receptor [gi:143811416]
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27
[SID103728028]
Kd 0.018Binding constant for SLK kinase domain [AID625086, Type: Literature]STE20-like serine/threonine-protein kinase [gi:74762732]
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28
[SID103728028]
IC50 0.02Inhibition of ALK in human KARPAS299 cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method [AID617233, Type: Literature]ALK tyrosine kinase receptor [gi:296439447]
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29
[SID103728028]
IC50 0.02Inhibition of ALK [AID383111, Type: Literature]
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30
[SID103728028]
IC50 0.024Inhibition of ABL [AID617340, Type: Literature]
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31
[SID103728028]
Kd 0.025Binding constant for MST1R kinase domain [AID624868, Type: Literature]Macrophage-stimulating protein receptor [gi:294862462]
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32
[SID103728028]
Kd 0.03Binding constant for LCK kinase domain [AID625013, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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33
[SID103728028]
Kd 0.031Binding constant for IRAK3 kinase domain [AID625066, Type: Literature]Interleukin-1 receptor-associated kinase 3 [gi:322510038]
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34
[SID103728028]
Kd 0.033Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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35
[SID103728028]
Kd 0.037Binding constant for TRKB kinase domain [AID625032, Type: Literature]BDNF/NT-3 growth factors receptor [gi:2497560]
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36
[SID103728028]
Kd 0.039Binding constant for HPK1 kinase domain [AID624816, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 1 [gi:29427916]
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37
[SID103728028]
Kd 0.044Binding constant for LOK kinase domain [AID625030, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
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38
[SID103728028]
Kd 0.049Binding constant for IRAK1 kinase domain [AID624837, Type: Literature]Interleukin-1 receptor-associated kinase 1 [gi:8928535]
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39
[SID103728028]
IC50 0.053Antiproliferative activity against human EBC1 cells expressing elevated levels of constitutively active c-Met after 72 hrs by SRB assay [AID678094, Type: Literature]
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40
[SID103728028]
Kd 0.06Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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41
[SID103728028]
Kd 0.065Binding constant for EPHA6 kinase domain [AID624748, Type: Literature]Ephrin type-A receptor 6 [gi:97048747]
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42
[SID103728028]
Kd 0.072Binding constant for MAP3K2 kinase domain [AID625062, Type: Literature]Mitogen-activated protein kinase kinase kinase 2 [gi:97536681]
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43
[SID103728028]
Kd 0.074Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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44
[SID103728028]
Kd 0.075Binding constant for MAP4K3 kinase domain [AID624921, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 3 [gi:29427817]
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45
[SID103728028]
Kd 0.076Binding constant for AURKB kinase domain [AID624772, Type: Literature]Aurora kinase B [gi:317373473]
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46
[SID103728028]
Kd 0.078Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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47
[SID103728028]
Kd 0.079Binding constant for MAP4K5 kinase domain [AID625061, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 5 [gi:30316147]
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48
[SID103728028]
Kd 0.08Binding constant for MAP4K2 kinase domain [AID624959, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 2 [gi:215274019]
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49
[SID103728028]
IC50 0.08Inhibition of RON in mouse 3T3 cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method [AID617236, Type: Literature]Macrophage-stimulating protein receptor [gi:341942147]
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50
[SID103728028]
Kd 0.082Binding constant for TRKC kinase domain [AID624765, Type: Literature]NT-3 growth factor receptor [gi:134035335]
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