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crizotinib (CID 11626560) - Compound BioActivity Data
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BioActivity Outcomes:
Active(388)
 
 
Inactive(15)
 
 
Inconclusive(2)
 
 
Unspecified(1059)
 
 
Top Targets:
PTKc Abl(17)
 
 
PTKc ALK LTK(14)
 
 
PTKc EGFR(12)
 
 
 
Sema MET(10)
 
 
PI3Kc IA alph..(10)
 
 
BioAssay Types:
Literature(1081)
 
 
 
Confirmatory(380)
 
 
 
 
 
BioActivity Types:
IC50(471)
 
 
 
Kd(442)
 
 
 
Potency(20)
 
 
 
 
EC50(3)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1463    Data Row: 1464   Total Pages: 74   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103728028]
Kd 0.00055Binding constant for MET(M1250T) kinase domain [AID624795, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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2
[SID103728028]
IC50 0.00078Inhibition of recombinant MET using biotinylated-poly(GT) peptide as substrate after 60 mins [AID608694, Type: Literature]
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3
[SID103728028]
IC50 0.001Inhibition of c-MET [AID617232, Type: Literature]
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4
[SID103728028]
IC50 0.001Inhibition of ALK [AID617235, Type: Literature]
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5
[SID103728028]
IC50 0.001Inhibition of AXL [AID617240, Type: Literature]
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6
[SID103728028]
IC50 0.001Inhibition of TRKA [AID617246, Type: Literature]
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7
[SID103728028]
IC50 0.001Inhibition of LCK [AID617346, Type: Literature]
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8
[SID103728028]
IC50 0.0011Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA [AID778852, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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9
[SID103728028]
Kd 0.0015Binding constant for MET(Y1235D) kinase domain [AID624796, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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10
[SID103728028]
IC50 0.0016Inhibition of c-Met incubated for 60 mins at spectrophotometry [AID678093, Type: Literature]
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11
[SID103728028]
IC50 0.002Inhibition of TRKB [AID617337, Type: Literature]
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12
[SID103728028]
Ki 0.002Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay [AID617229, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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13
[SID103728028]
Kd 0.0021Binding constant for MET kinase domain [AID624794, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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14
[SID103728028]
Kd 0.0033Binding constant for ALK kinase domain [AID624944, Type: Literature]ALK tyrosine kinase receptor [gi:296439447]
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15
[SID103728028]
Kd 0.0036Binding constant for MERTK kinase domain [AID624767, Type: Literature]Tyrosine-protein kinase Mer [gi:160332297]
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16
[SID103728028]
IC50 0.004Inhibition of human c-MET [AID614836, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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17
[SID103728028]
Kd 0.0041Binding constant for ROS1 kinase domain [AID624899, Type: Literature]Proto-oncogene tyrosine-protein kinase ROS [gi:126302596]
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18
[SID103728028]
IC50 0.005Inhibition of TIE2 [AID617243, Type: Literature]
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19
[SID103728028]
IC50 0.00501Inhibition of ALK (unknown origin) [AID767456, Type: Literature]ALK tyrosine kinase receptor [gi:296439447]
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20
[SID103728028]
Kd 0.006Binding constant for EPHB6 kinase domain [AID624957, Type: Literature]Ephrin type-B receptor 6 [gi:294862532]
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