Bookmark and Share

BioActivity Data for Compound carfilzomib (CID 11556711)

BioActivity Outcomes:
Active(80)
 
 
Inactive(60)
 
 
Inconclusive(41)
 
 
Unspecified(19)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
proteasome be..(5)
 
 
 
NR LBD Fxr(4)
 
 
 
BioAssay Types:
Confirmatory(114)
 
 
 
 
Literature(46)
 
 
 
 
Summary(24)
 
 
 
 
Screening(15)
 
 
 
BioActivity Types:
Potency(112)
 
 
 
 
IC50(22)
 
 
 
AC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 182    Data Row: 200   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID170466878]
IC50 0.00147SNU-C1 viability from Cell TiterGlo-IC50 [AID1117323, Type: confirmatory]
View
2
[SID170466878]
IC50 0.00173GSK3B-pretreated HCT116 viability from Cell TiterGlo-IC50 [AID1117339, Type: confirmatory]
View
3
[SID170466878]
IC50 0.00318HT-29 viability from Cell TiterGlo-IC50 [AID1117330, Type: confirmatory]
View
4
[SID124955654]
Potency 0.0033qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. [AID624479, Type: confirmatory]
View
5
[SID170466878]
IC50 0.00394RKO viability from Cell TiterGlo-IC50 [AID1117322, Type: confirmatory]
View
6
[SID144206630]
Potency 0.0042qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
7
[SID103652542]
IC50 0.0051Inhibition of chymotrypsin-like activity of 20S proteasome in human MOLT4 cells after 1 hr by CellTiter-Glo luminescent assay [AID353767, Type: Literature]
View
8
[SID103652542]
IC50 0.0052Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit by proteasome active site ELISA [AID353999, Type: Literature]
View
9
[SID170466878]
IC50 0.00558HCT116 viability from Cell TiterGlo-IC50 [AID1117332, Type: confirmatory]
View
10
[SID103652542]
IC50 0.0057Inhibition of chymotrypsin-like activity of human 20S proteasome by spectrofluorimetry [AID353766, Type: Literature]
View
11
[SID144206630]
Potency 0.0067qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
12
[SID170466878]
IC50 0.00696DLD-1 viability from Cell TiterGlo-IC50 [AID1117352, Type: confirmatory]
View
13
[SID170466878]
IC50 0.00761SW480 viability from Cell TiterGlo-IC50 [AID1117338, Type: confirmatory]
View
14
[SID170466878]
IC50 0.0099Decreased HeLa cell count-IC50 [AID1117347, Type: confirmatory]
View
15
[SID144206630]
Potency 0.0118qHTS Assay for Identifying Gametocytocidal Compounds [AID743244, Type: confirmatory]
View
16
[SID144206630]
Potency-Replicate_1 0.0119qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
17
[SID144206630]
Potency-Replicate_1 0.0119qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
View
18
[SID103652542]
IC50 0.014Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISA [AID354000, Type: Literature]
View
19
[SID170466878]
IC50 0.0152alkaline phosphatase stimulation in WNT3A conditioned C2C12 cells-IC50 [AID1117327, Type: confirmatory]
View
20
[SID144206630]
Potency-Replicate_1 0.0168qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View