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carfilzomib (CID 11556711) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(59)
 
 
Inactive(42)
 
 
Inconclusive(41)
 
 
Unspecified(19)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
proteasome be..(5)
 
 
 
NR LBD Fxr(4)
 
 
 
BioAssay Types:
Confirmatory(89)
 
 
 
 
Literature(27)
 
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(108)
 
 
 
 
IC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 143    Data Row: 161   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124955654]
Potency 0.0033qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. [AID624479, Type: confirmatory]
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2
[SID144206630]
Potency 0.0042qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID103652542]
IC50 0.0051Inhibition of chymotrypsin-like activity of 20S proteasome in human MOLT4 cells after 1 hr by CellTiter-Glo luminescent assay [AID353767, Type: Literature]
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4
[SID103652542]
IC50 0.0052Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit by proteasome active site ELISA [AID353999, Type: Literature]
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5
[SID103652542]
IC50 0.0057Inhibition of chymotrypsin-like activity of human 20S proteasome by spectrofluorimetry [AID353766, Type: Literature]
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6
[SID144206630]
Potency 0.0067qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID144206630]
Potency-Replicate_1 0.0119qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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8
[SID144206630]
Potency-Replicate_1 0.0119qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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9
[SID103652542]
IC50 0.014Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISA [AID354000, Type: Literature]
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10
[SID144206630]
Potency-Replicate_1 0.0168qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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11
[SID103652542]
IC50 0.018Cytotoxicity against human MESSA cells assessed as cell viability after 72 hrs by CellTiter-Glo luminescent assay [AID353771, Type: Literature]
View
12
[SID144206630]
Potency-Replicate_1 0.0298qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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13
[SID144206630]
Potency-Replicate_1 0.0335qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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14
[SID144206630]
Ratio Potency (uM) 0.0337801qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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15
[SID144206630]
Potency-Replicate_1 0.0422qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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16
[SID170466878]
Ratio Potency (uM) 0.0446581qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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17
[SID144206630]
Potency-Replicate_1 0.0473qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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18
[SID144206630]
Ratio Potency (uM) 0.0600704qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID170466878]
Potency-Replicate_1 0.0668qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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20
[SID144206630]
Potency-Replicate_1 0.0668qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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21
[SID144206630]
Ratio Potency (uM) 0.0817399qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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22
[SID144206630]
Potency-Replicate_1 0.1059qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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23
[SID144206630]
Potency-Replicate_1 0.1059qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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24
[SID144206630]
ATAD5 Potency (uM) 0.114358qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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25
[SID144206630]
AR Potency (uM) 0.138548qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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26
[SID124955654]
Potency 0.1482Cytotoxicity counterscreen for NFkB agonists and antagonists [AID624476, Type: confirmatory]
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27
[SID144206630]
ER Potency (uM) 0.174422qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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28
[SID144206630]
Potency-Replicate_1 0.1883qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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29
[SID170466878]
Ratio Potency (uM) 0.188322qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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30
[SID144206630]
Potency-Replicate_1 0.2113qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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31
[SID170466878]
Potency-Replicate_1 0.2371qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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32
[SID170466878]
Potency-Replicate_1 0.266qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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33
[SID144206630]
Potency-Replicate_1 0.3349qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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34
[SID103652542]
IC50 0.413Cytotoxicity against multidrug resistance transporter expressing doxorubicin resistant human MESSA cells assessed as cell viability after 72 hrs by CellTiter-Glo luminescent assay [AID353772, Type: Literature]
View
35
[SID144206630]
Potency-Replicate_1 0.6007qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
36
[SID170466878]
Potency-Replicate_1 3.0107qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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37
[SID144206630]
Potency-Replicate_1 5.3538qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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38
[SID144206630]
Potency 11.2202qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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39
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit alpha type-7 [gi:12643540]
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40
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit beta type-7 [gi:17380263]
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41
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit beta type-10 [gi:730376]
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42
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit beta type-2 [gi:1709762]
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43
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit beta type-1 [gi:130853]
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44
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit alpha type-3 [gi:130859]
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45
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit alpha type-4 [gi:130861]
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46
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit alpha type-1 [gi:130848]
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47
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit alpha type-2 [gi:130850]
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48
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit beta type-9 [gi:417529]
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49
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit alpha type-7-like [gi:108936006]
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50
[SID103652542]
26S proteosome inhibitor [AID742590, Type: other]Proteasome subunit beta type-4 [gi:116242733]
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