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carfilzomib (CID 11556711) - Compound BioActivity Data
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BioActivity Outcomes:
Active(59)
 
 
Inactive(46)
 
 
Inconclusive(41)
 
 
Unspecified(19)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
NR LBD ER(7)
 
 
 
NR LBD AR(7)
 
 
 
 
proteasome be..(5)
 
 
 
NR LBD Fxr(4)
 
 
 
BioAssay Types:
Confirmatory(92)
 
 
 
 
Literature(46)
 
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(112)
 
 
 
 
IC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 147    Data Row: 165   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124955654]
Potency 0.0033qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. [AID624479, Type: confirmatory]
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2
[SID144206630]
Potency 0.0042qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID103652542]
IC50 0.0051Inhibition of chymotrypsin-like activity of 20S proteasome in human MOLT4 cells after 1 hr by CellTiter-Glo luminescent assay [AID353767, Type: Literature]
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4
[SID103652542]
IC50 0.0052Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit by proteasome active site ELISA [AID353999, Type: Literature]
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5
[SID103652542]
IC50 0.0057Inhibition of chymotrypsin-like activity of human 20S proteasome by spectrofluorimetry [AID353766, Type: Literature]
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6
[SID144206630]
Potency 0.0067qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID144206630]
Potency 0.0118qHTS Assay for Identifying Gametocytocidal Compounds [AID743244, Type: confirmatory]
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8
[SID144206630]
Potency-Replicate_1 0.0119qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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9
[SID144206630]
Potency-Replicate_1 0.0119qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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10
[SID103652542]
IC50 0.014Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISA [AID354000, Type: Literature]
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11
[SID144206630]
Potency-Replicate_1 0.0168qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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12
[SID103652542]
IC50 0.018Cytotoxicity against human MESSA cells assessed as cell viability after 72 hrs by CellTiter-Glo luminescent assay [AID353771, Type: Literature]
View
13
[SID144206630]
Potency-Replicate_1 0.0298qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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14
[SID144206630]
Potency-Replicate_1 0.0335qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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15
[SID144206630]
Ratio Potency (uM) 0.0337801qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144206630]
Potency-Replicate_1 0.0422qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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17
[SID170466878]
Ratio Potency (uM) 0.0446581qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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18
[SID144206630]
Potency-Replicate_1 0.0473qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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19
[SID144206630]
Ratio Potency (uM) 0.0600704qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID170466878]
Potency-Replicate_1 0.0668qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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