CHEMBL1253499 (CID 11549135) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Unspecified(4)
 
 
Top Targets:
DUF1856(2)
 
 
BioAssay Types:
Literature(12)
 
 
 
BioActivity Types:
Ki(8)
 
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 13    Data Row: 13   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123096000]
Ki 0.0005Displacement of [3H]-oxytocin from human oxytocin receptor expressed in CHO cells [AID513698, Type: Literature]Oxytocin receptor [gi:143811431]
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2
[SID123096000]
Ki 0.0005Displacement of [3H]-oxytocin from human oxytocin receptor expressed in CHO cells [AID513698, Type: Literature]Oxytocin receptor [gi:143811431]
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3
[SID123096000]
Ki 0.0005Displacement of [3H]-oxytocin from human oxytocin receptor expressed in CHO cells [AID513698, Type: Literature]Oxytocin receptor [gi:143811431]
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4
[SID123096000]
Ki 0.0016Displacement of [3H]-oxytocin from rat oxytocin receptor expressed in CHO cells [AID513702, Type: Literature]Oxytocin receptor [gi:18269702]
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5
[SID123096000]
Kd 0.00339Antagonist activity at oxytocin receptor in rat uterine strips assessed as inhibition of oxytocin-induced contraction [AID513707, Type: Literature]Oxytocin receptor [gi:18269702]
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6
[SID123096000]
ED50 0.0047Inhibition of oxytocin-induced uterine contraction in po dosed rat after 24 hrs [AID513721, Type: Literature]
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7
[SID123096000]
ED50 0.014Inhibition of oxytocin-induced uterine contraction in po dosed rat after 1 hr [AID513719, Type: Literature]
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8
[SID123096000]
ED50 0.024Inhibition of oxytocin-induced uterine contraction in po dosed rat after 5 hrs [AID513720, Type: Literature]
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9
[SID123096000]
Ki 0.046Displacement of [3H]vasopressin from rat vasopressin V1b receptor expressed in CHO cells [AID513718, Type: Literature]Vasopressin V1b receptor [gi:1351393]
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10
[SID123096000]
Ki 0.099Displacement of [3H]vasopressin from rat vasopressin V1a receptor expressed in CHO cells [AID513703, Type: Literature]Vasopressin V1a receptor [gi:108935913]
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11
[SID123096000]
Ki 0.143Displacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cells [AID513699, Type: Literature]Vasopressin V1a receptor [gi:586197]
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12
[SID123096000]
Ki 0.143Displacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cells [AID513699, Type: Literature]Vasopressin V1a receptor [gi:586197]
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13
[SID123096000]
Ki 0.143Displacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cells [AID513699, Type: Literature]Vasopressin V1a receptor [gi:586197]
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14
[SID123096000]
Ki 0.000501GRAC: human OT selective antagonist [AID540542, Type: other]Oxytocin receptor [gi:143811431]
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15
[SID123096000]
Ki 0.000501GRAC: human OT selective antagonist [AID540542, Type: other]Oxytocin receptor [gi:143811431]
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16
[SID123096000]
Ki 0.000501GRAC: human OT selective antagonist [AID540542, Type: other]Oxytocin receptor [gi:143811431]
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17
[SID123096000]
Ki 1Displacement of [3H]vasopressin from human vasopressin V2 receptor expressed in CHO cells [AID513705, Type: Literature]Vasopressin V2 receptor [gi:267256]
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18
[SID123096000]
Ki 1Displacement of [3H]vasopressin from human vasopressin V2 receptor expressed in CHO cells [AID513705, Type: Literature]Vasopressin V2 receptor [gi:267256]
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19
[SID123096000]
Ki 1Displacement of [3H]vasopressin from human vasopressin V2 receptor expressed in CHO cells [AID513705, Type: Literature]Vasopressin V2 receptor [gi:267256]
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20
[SID123096000]
Ki 1Displacement of [3H]vasopressin from rat vasopressin V2 receptor expressed in CHO cells [AID513704, Type: Literature]Vasopressin V2 receptor [gi:465020]
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21
[SID123096000]
 Selectivity ratio of Ki for human oxytocin receptor Ki for human vasopressin V2 receptor [AID513693, Type: Literature]
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