N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea (CID 11485656) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(294)
 
 
Inactive(168)
 
 
Inconclusive(1)
 
 
Unspecified(629)
 
 
Top Targets:
PKc(97)
 
 
 
 
PKc like(63)
 
 
 
 
STKc AGC(51)
 
 
 
 
PTKc Abl(26)
 
 
 
 
PTKc EGFR(23)
 
 
 
 
BioAssay Types:
Literature(1008)
 
 
 
 
Confirmatory(80)
 
 
 
 
BioActivity Types:
Kd(761)
 
 
 
IC50(30)
 
 
 
Potency(8)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 853    Data Row: 1092   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103510213]
Kd 0.00063Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
2
[SID103510213]
Kd 0.00063Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
3
[SID103510213]
Kd 0.00063Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
4
[SID103510213]
Kd 0.00063Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
5
[SID103510213]
Kd 0.00063Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
6
[SID103510213]
Kd 0.00063Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
7
[SID103510213]
Kd 0.0013Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
8
[SID103510213]
Kd 0.0013Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
9
[SID103510213]
Kd 0.0013Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
10
[SID103510213]
Kd 0.0017Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
11
[SID103510213]
Kd 0.0017Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
12
[SID103510213]
Kd 0.0017Binding constant for KIT(V559D) kinase domain [AID435167, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
13
[SID103510213]
Kd 0.0017Binding constant for KIT(V559D) kinase domain [AID435167, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
14
[SID103510213]
Kd 0.0019Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
15
[SID103510213]
Kd 0.0019Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
16
[SID103510213]
Kd 0.0019Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
View
17
[SID103510213]
Kd 0.0019Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
View
18
[SID103510213]
Kd 0.0019Binding constant for PDGFRB kinase domain [AID435926, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
View
19
[SID103510213]
Kd 0.0019Binding constant for PDGFRB kinase domain [AID435926, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
View
20
[SID103510213]
Kd 0.002Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
21
[SID103510213]
Kd 0.002Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
22
[SID103510213]
Kd 0.002Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
23
[SID103510213]
Kd 0.002Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
24
[SID103510213]
Kd 0.002Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
25
[SID103510213]
Kd 0.002Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
26
[SID103510213]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
27
[SID103510213]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
28
[SID103510213]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
29
[SID103510213]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID435162, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
30
[SID103510213]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID435162, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
31
[SID103510213]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID435162, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
32
[SID103510213]
Kd 0.0027Binding constant for FLT3(D835H) kinase domain [AID435406, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
33
[SID103510213]
Kd 0.0027Binding constant for FLT3(D835H) kinase domain [AID435406, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
34
[SID103510213]
Kd 0.0027Binding constant for FLT3(D835H) kinase domain [AID435406, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
35
[SID103510213]
Kd 0.0027Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
36
[SID103510213]
Kd 0.0027Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
37
[SID103510213]
Kd 0.0027Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
38
[SID103510213]
IC50 0.003Inhibition of FLT1 by HTRF assay [AID281038, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
View
39
[SID103510213]
IC50 0.003Inhibition of FLT1 by HTRF assay [AID281038, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
View
40
[SID103510213]
IC50 0.003Inhibition of CSF1R by HTRF assay [AID281041, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
View
41
[SID103510213]
IC50 0.003Inhibition of CSF1R by HTRF assay [AID281041, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
View
42
[SID103510213]
Kd 0.0034Binding constant for CSF1R kinase domain [AID435280, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
View
43
[SID103510213]
Kd 0.0034Binding constant for CSF1R kinase domain [AID435280, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
View
44
[SID103510213]
Kd 0.0034Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
View
45
[SID103510213]
Kd 0.0034Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
View
46
[SID103510213]
Kd 0.0038Binding constant for KIT(V559D,T670I) kinase domain [AID435675, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
47
[SID103510213]
Kd 0.0038Binding constant for KIT(V559D,T670I) kinase domain [AID435675, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
48
[SID103510213]
Kd 0.0038Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
49
[SID103510213]
Kd 0.0038Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
50
[SID103510213]
IC50 0.004Inhibition of KDR by HTRF assay [AID281030, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
View