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N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea (CID 11485656) - Compound BioActivity Data
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BioActivity Outcomes:
Active(295)
 
 
Inactive(175)
 
 
Inconclusive(1)
 
 
Unspecified(629)
 
 
Top Targets:
PKc(87)
 
 
 
 
PKc like(67)
 
 
 
 
STKc AGC(36)
 
 
 
 
PTKc Abl(25)
 
 
 
 
PTKc EGFR(23)
 
 
 
 
BioAssay Types:
Literature(1009)
 
 
 
 
Confirmatory(87)
 
 
 
 
BioActivity Types:
Kd(761)
 
 
 
IC50(30)
 
 
 
Potency(16)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 861    Data Row: 1100   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103510213]
Kd 0.00063Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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2
[SID103510213]
Kd 0.00063Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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3
[SID103510213]
Kd 0.0013Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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4
[SID103510213]
Kd 0.0017Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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5
[SID103510213]
Kd 0.0017Binding constant for KIT(V559D) kinase domain [AID435167, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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6
[SID103510213]
Kd 0.0019Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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7
[SID103510213]
Kd 0.0019Binding constant for PDGFRB kinase domain [AID435926, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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8
[SID103510213]
Kd 0.0019Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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9
[SID103510213]
Kd 0.002Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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10
[SID103510213]
Kd 0.002Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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11
[SID103510213]
Kd 0.002Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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12
[SID103510213]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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13
[SID103510213]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID435162, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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14
[SID103510213]
Kd 0.0027Binding constant for FLT3(D835H) kinase domain [AID435406, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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15
[SID103510213]
Kd 0.0027Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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16
[SID103510213]
IC50 0.003Inhibition of FLT1 by HTRF assay [AID281038, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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17
[SID103510213]
IC50 0.003Inhibition of CSF1R by HTRF assay [AID281041, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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18
[SID103510213]
Kd 0.0034Binding constant for CSF1R kinase domain [AID435280, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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19
[SID103510213]
Kd 0.0034Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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20
[SID103510213]
Kd 0.0038Binding constant for KIT(V559D,T670I) kinase domain [AID435675, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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21
[SID103510213]
Kd 0.0038Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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22
[SID103510213]
IC50 0.004Inhibition of KDR by HTRF assay [AID316725, Type: Literature]
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23
[SID103510213]
IC50 0.004Inhibition of KDR by HTRF assay [AID281030, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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24
[SID103510213]
IC50 0.004Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA [AID281033, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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25
[SID103510213]
Kd 0.0042Binding constant for PDGFRA kinase domain [AID435827, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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26
[SID103510213]
Kd 0.0042Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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27
[SID103510213]
IC50 0.005Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay [AID608698, Type: Literature]
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28
[SID103510213]
IC50 0.005Inhibition of FLT3 by HTRF assay [AID281031, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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29
[SID103510213]
IC50 0.007Inhibition of VEGFR2 [AID674404, Type: Literature]
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30
[SID103510213]
Kd 0.0075Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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31
[SID103510213]
Kd 0.0075Binding constant for FLT1 kinase domain [AID435429, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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32
[SID103510213]
Kd 0.0081Binding constant for VEGFR2 kinase domain [AID435327, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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33
[SID103510213]
Kd 0.0081Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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34
[SID103510213]
Kd 0.0088Binding constant for FLT3(ITD) kinase domain [AID435310, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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35
[SID103510213]
Kd 0.0088Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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36
[SID103510213]
Kd 0.01Binding constant for MUSK kinase domain [AID625022, Type: Literature]Muscle, skeletal receptor tyrosine-protein kinase [gi:50400806]
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37
[SID103510213]
Kd 0.01Binding constant for MUSK kinase domain [AID435678, Type: Literature]Muscle, skeletal receptor tyrosine-protein kinase [gi:50400806]
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38
[SID103510213]
Kd 0.011Binding constant for FLT3(D835Y) kinase domain [AID435407, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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39
[SID103510213]
Kd 0.011Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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40
[SID103510213]
Kd 0.016Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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41
[SID103510213]
Kd 0.016Binding constant for FLT4 kinase domain [AID436018, Type: Literature]Vascular endothelial growth factor receptor 3 [gi:357529070]
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42
[SID103510213]
Kd 0.016Binding constant for FLT4 kinase domain [AID624854, Type: Literature]Vascular endothelial growth factor receptor 3 [gi:357529070]
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43
[SID103510213]
IC50 0.016Inhibition of c-Kit by HTRF method [AID471496, Type: Literature]
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44
[SID103510213]
IC50 0.016Inhibition of c-Kit by HTRF assay [AID281032, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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45
[SID103510213]
Kd 0.017Binding constant for KIT(A829P) kinase domain [AID624787, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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46
[SID103510213]
IC50 0.02Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assay [AID608702, Type: Literature]
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47
[SID103510213]
IC50 0.02Inhibition of wild type FLT3 [AID674402, Type: Literature]
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48
[SID103510213]
Kd 0.021Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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49
[SID103510213]
Kd 0.021Binding constant for KIT(V559D,V654A) kinase domain [AID435802, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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50
[SID103510213]
IC50 0.028Inhibition of KDR by HTRF assay [AID344329, Type: Literature]
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