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N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea (CID 11485656) - Compound BioActivity Data
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BioActivity Outcomes:
Active(300)
 
 
Inactive(179)
 
 
Inconclusive(1)
 
 
Unspecified(629)
 
 
Top Targets:
PTKc Abl(25)
 
 
 
 
PTKc EGFR(23)
 
 
 
 
ig(20)
 
 
 
 
PTKc Kit(20)
 
 
 
PKc like(15)
 
 
 
 
BioAssay Types:
Literature(1014)
 
 
 
 
Confirmatory(90)
 
 
 
 
BioActivity Types:
Kd(761)
 
 
 
IC50(34)
 
 
 
Potency(20)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 870    Data Row: 1109   Total Pages: 56   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103510213]
Kd 0.00063Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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2
[SID103510213]
Kd 0.00063Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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3
[SID103510213]
Kd 0.0013Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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4
[SID103510213]
Kd 0.0017Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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5
[SID103510213]
Kd 0.0017Binding constant for KIT(V559D) kinase domain [AID435167, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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6
[SID103510213]
Kd 0.0019Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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7
[SID103510213]
Kd 0.0019Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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8
[SID103510213]
Kd 0.0019Binding constant for PDGFRB kinase domain [AID435926, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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9
[SID103510213]
Kd 0.002Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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10
[SID103510213]
Kd 0.002Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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11
[SID103510213]
Kd 0.002Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
12
[SID103510213]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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13
[SID103510213]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID435162, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
14
[SID103510213]
Kd 0.0027Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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15
[SID103510213]
Kd 0.0027Binding constant for FLT3(D835H) kinase domain [AID435406, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
16
[SID103510213]
IC50 0.003Inhibition of FLT1 by HTRF assay [AID281038, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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17
[SID103510213]
IC50 0.003Inhibition of CSF1R by HTRF assay [AID281041, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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18
[SID103510213]
Kd 0.0034Binding constant for CSF1R kinase domain [AID435280, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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19
[SID103510213]
Kd 0.0034Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
View
20
[SID103510213]
Kd 0.0038Binding constant for KIT(V559D,T670I) kinase domain [AID435675, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View