CHEMBL364748 (CID 11460087) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Unspecified(7)
 
 
Top Targets:
NR LBD PPAR(12)
 
 
 
BioAssay Types:
Literature(14)
 
 
 
BioActivity Types:
EC50(7)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 14    Data Row: 14   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103460282]
EC50 0.0013Effective concentration against murine PPARalpha in transactivation assay [AID240162, Type: Literature]
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2
[SID103460282]
EC50 2.7Effective concentration against human PPARgamma expressed in HepG2 cells [AID240268, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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3
[SID103460282]
EC50 2.7Effective concentration against human PPARgamma expressed in HepG2 cells [AID240268, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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4
[SID103460282]
EC50 2.7Effective concentration against human PPARgamma expressed in HepG2 cells [AID240268, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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5
[SID103460282]
EC50 2.7Effective concentration against human PPARgamma expressed in HepG2 cells [AID240268, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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6
[SID103460282]
EC50 3.9Effective concentration against human PPARalpha expressed in HepG2 cells [AID240267, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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7
[SID103460282]
EC50 3.9Effective concentration against human PPARalpha expressed in HepG2 cells [AID240267, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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8
[SID103460282]
EC50 4.9Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay [AID648525, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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9
[SID103460282]
EC50 4.9Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay [AID648525, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
10
[SID103460282]
EC50 7.94Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay [AID344819, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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11
[SID103460282]
EC50 7.94Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay [AID344819, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
12
[SID103460282]
EC50 7.94Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay [AID344819, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
13
[SID103460282]
EC50 7.94Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay [AID344819, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
14
[SID103460282]
EC50 9.6Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay [AID648526, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
15
[SID103460282]
EC50 9.6Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay [AID648526, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
16
[SID103460282]
EC50 9.6Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay [AID648526, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
17
[SID103460282]
EC50 9.6Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay [AID648526, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
18
[SID103460282]
EC50 14.46Agonist activity at human PPARalpha ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay [AID344821, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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19
[SID103460282]
EC50 14.46Agonist activity at human PPARalpha ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay [AID344821, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
20
[SID103460282]
 Agonist activity at human PPARalpha ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay relative to Wy-14,643 [AID344822, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
21
[SID103460282]
 Agonist activity at human PPARalpha ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay relative to Wy-14,643 [AID344822, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
22
[SID103460282]
 Efficacy against human PPARalpha expressed in HepG2 cells relative to Wy-14,643 [AID243395, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
23
[SID103460282]
 Efficacy against human PPARalpha expressed in HepG2 cells relative to Wy-14,643 [AID243395, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
24
[SID103460282]
 Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay relative to Wy-14643 [AID648529, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
25
[SID103460282]
 Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay relative to Wy-14643 [AID648529, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
26
[SID103460282]
 Efficacy against human PPARgamma expressed in HepG2 cells relative to rosiglitazone [AID243396, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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27
[SID103460282]
 Efficacy against human PPARgamma expressed in HepG2 cells relative to rosiglitazone [AID243396, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
28
[SID103460282]
 Efficacy against human PPARgamma expressed in HepG2 cells relative to rosiglitazone [AID243396, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
29
[SID103460282]
 Efficacy against human PPARgamma expressed in HepG2 cells relative to rosiglitazone [AID243396, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
30
[SID103460282]
 Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay relative to rosiglitazone [AID344820, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
31
[SID103460282]
 Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay relative to rosiglitazone [AID344820, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
32
[SID103460282]
 Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay relative to rosiglitazone [AID344820, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
33
[SID103460282]
 Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay relative to rosiglitazone [AID344820, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
34
[SID103460282]
 Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay relative to pioglitazone [AID648530, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
35
[SID103460282]
 Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay relative to pioglitazone [AID648530, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
36
[SID103460282]
 Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay relative to pioglitazone [AID648530, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
37
[SID103460282]
 Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay relative to pioglitazone [AID648530, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
38
[SID103460282]
 Efficacy against murine PPARalpha relative to Wy-14,643 [AID243394, Type: Literature]
View