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BioActivity Data for Compound trimethylamine (CID 1146)

BioActivity Outcomes:
Inactive(93)
 
 
Inconclusive(10)
 
 
Unspecified(4)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
NR LBD AR(7)
 
 
 
NR LBD ER(7)
 
 
NR LBD Fxr(4)
 
 
NR LBD GR(4)
 
 
BioAssay Types:
Confirmatory(72)
 
 
 
Summary(28)
 
 
 
Literature(7)
 
 
 
BioAssay Categories:
Biochemical(4)
 
 
 
Toxicity(6)
 
 
BioActivity Types:
Potency(94)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 107    Data Row: 107   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179282]
Ki 340.017Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosome [AID494749, Type: Literature]High affinity choline transporter 1 [gi:56404887]
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2
[SID103179282]
pKa (acid-base dissociation constant) as determined by Morgenthaler ref: ChemMedChem 2007 [AID781327, Type: Literature]
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3
[SID103179282]
Aqueous solubility [AID19262, Type: Literature]
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4
[SID103179282]
Dissociation constant, pKa of the compound [AID1132810, Type: Literature]
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5
[SID144212672]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the NFkB signaling pathway - cell viability counter screen [AID1159515, Type: confirmatory]
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6
[SID144212672]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway - cell viability counter screen [AID1159517, Type: confirmatory]
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7
[SID144212672]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen [AID1159520, Type: confirmatory]
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8
[SID144212672]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the AP-1 signaling pathway [AID1159526, Type: confirmatory]
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9
[SID144212672]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the AP-1 signaling pathway - cell viability counter screen [AID1159525, Type: confirmatory]
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10
[SID144212672]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the RXR signaling pathway - cell viability counter screen [AID1159529, Type: confirmatory]
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11
[SID144212672]
Potency-Replicate_1 qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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12
[SID144212672]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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13
[SID144212672]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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14
[SID144212672]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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15
[SID144212672]
Ratio Potency (uM) qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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16
[SID144212672]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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17
[SID144212672]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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18
[SID144212672]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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19
[SID144212672]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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20
[SID144212672]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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