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zampanolide (CID 11454753) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(9)
 
 
Unspecified(14)
 
 
BioAssay Types:
Literature(23)
 
 
 
BioActivity Types:
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 23    Data Row: 23   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103699725]
IC50 0.0043Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID441619, Type: Literature]
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2
[SID103699725]
IC50 0.0071Cytotoxicity against human A2780 cells by MTT cell proliferation assay [AID441640, Type: Literature]
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3
[SID103699725]
IC50 0.0075Cytotoxicity against p-glycoprotein overexpressing human A2780AD cells by MTT cell proliferation assay [AID441641, Type: Literature]
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4
[SID103699725]
IC50 0.0143Cytotoxicity against human 1A9 cells after 72 hrs by MTT assay [AID441620, Type: Literature]
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5
[SID103699725]
Cytotoxicity against human HL60 cells at 2 nM after 24 hrs by Trypan blue exclusion test [AID441621, Type: Literature]
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6
[SID103699725]
Cytotoxicity against human HL60 cells assessed as cell death at 10 nM after 48 hrs by Trypan blue exclusion test [AID441622, Type: Literature]
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7
[SID103699725]
Cell cycle arrest in human HL60 cells assessed as accumulation in G2/M phase at 2 to 10 nM after 16 hrs by flow cytometry [AID441627, Type: Literature]
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8
[SID103699725]
Induction of tubulin polymerization in human 1A9 cells at 100 nM after 16 hrs by Western blotting [AID441637, Type: Literature]
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9
[SID103699725]
Induction of bovine tubulin polymerization at 10 uM after 1hr in presence of 1 mM GTP [AID441638, Type: Literature]
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10
[SID103699725]
Selectivity ratio of IC50 for p-glycoprotein overexpressing human A2780AD cells to IC50 for human A2780 cells [AID441639, Type: Literature]
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11
[SID103699725]
Cytotoxicity against human 1A9 cells assessed as interphase cells with microtubule bundles at 5 nM after 12 hrs by immunocytochemistry [AID441628, Type: Literature]
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12
[SID103699725]
Cytotoxicity against human 1A9 cells assessed as interphase cells with microtubule bundles at 8 nM after 12 hrs by immunocytochemistry [AID441629, Type: Literature]
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13
[SID103699725]
Cytotoxicity against human 1A9 cells assessed as interphase cells with microtubule bundles at 10 nM after 12 hrs by immunocytochemistry [AID441630, Type: Literature]
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14
[SID103699725]
Cytotoxicity against human 1A9 cells assessed as interphase cells with microtubule bundles at 20 nM after 12 hrs by immunocytochemistry [AID441631, Type: Literature]
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15
[SID103699725]
Cytotoxicity against human 1A9 cells assessed as mitotic cells with multiple asters at 5 nM after 12 hrs by immunocytochemistry [AID441632, Type: Literature]
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16
[SID103699725]
Cytotoxicity against human 1A9 cells assessed as mitotic cells with multiple asters at 8 nM after 12 hrs by immunocytochemistry [AID441633, Type: Literature]
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17
[SID103699725]
Cytotoxicity against human 1A9 cells assessed as mitotic cells with multiple asters at 10 nM after 12 hrs by immunocytochemistry [AID441634, Type: Literature]
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18
[SID103699725]
Cytotoxicity against human 1A9 cells assessed as mitotic cells with multiple asters at 20 nM after 12 hrs by immunocytochemistry [AID441635, Type: Literature]
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19
[SID103699725]
Induction of tubulin polymerization in human 1A9 cells after 16 hrs by Western blotting [AID441636, Type: Literature]
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20
[SID103699725]
Cytotoxicity against human HL60 cells assessed as increase in cell diameter after 48 hrs by Giemsa staining [AID441623, Type: Literature]
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21
[SID103699725]
Cytotoxicity against human HL60 cells assessed as increase in cell diameter at 2 nM after 48 hrs by Giemsa staining [AID441624, Type: Literature]
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22
[SID103699725]
Cytotoxicity against human HL60 cells assessed as increase in cell diameter at 4 nM after 48 hrs by Giemsa staining [AID441625, Type: Literature]
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23
[SID103699725]
Cytotoxicity against human HL60 cells assessed as increase in cell diameter at 8 nM after 48 hrs by Giemsa staining [AID441626, Type: Literature]
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