AST 487 (CID 11409972) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(482)
 
 
Inactive(186)
 
 
Unspecified(339)
 
 
Top Targets:
PKc(106)
 
 
 
 
PKc like(68)
 
 
 
 
STKc AGC(55)
 
 
 
 
PTKc Abl(32)
 
 
 
 
PTKc EGFR(31)
 
 
 
 
BioAssay Types:
Literature(843)
 
 
 
 
Confirmatory(163)
 
 
 
BioActivity Types:
Kd(761)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 764    Data Row: 1007   Total Pages: 21   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103694306]
Kd 0.00029Binding constant for TIE1 kinase domain [AID625017, Type: Literature]Tyrosine-protein kinase receptor Tie-1 [gi:549081]
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2
[SID103694306]
Kd 0.00029Binding constant for TIE1 kinase domain [AID625017, Type: Literature]Tyrosine-protein kinase receptor Tie-1 [gi:549081]
View
3
[SID103694306]
Kd 0.00029Binding constant for TIE1 kinase domain [AID435198, Type: Literature]Tyrosine-protein kinase receptor Tie-1 [gi:549081]
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4
[SID103694306]
Kd 0.00029Binding constant for TIE1 kinase domain [AID435198, Type: Literature]Tyrosine-protein kinase receptor Tie-1 [gi:549081]
View
5
[SID103694306]
Kd 0.00051Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
6
[SID103694306]
Kd 0.00051Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
7
[SID103694306]
Kd 0.00051Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
8
[SID103694306]
Kd 0.00052Binding constant for CDKL2 kinase domain [AID624928, Type: Literature]Cyclin-dependent kinase-like 2 [gi:74762639]
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9
[SID103694306]
Kd 0.00052Binding constant for CDKL2 kinase domain [AID624928, Type: Literature]Cyclin-dependent kinase-like 2 [gi:74762639]
View
10
[SID103694306]
Kd 0.00068Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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11
[SID103694306]
Kd 0.00068Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
12
[SID103694306]
Kd 0.00069Binding constant for DDR1 kinase domain [AID435400, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
View
13
[SID103694306]
Kd 0.00069Binding constant for DDR1 kinase domain [AID435400, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
View
14
[SID103694306]
Kd 0.00069Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
View
15
[SID103694306]
Kd 0.00069Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
View
16
[SID103694306]
Kd 0.00074Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
17
[SID103694306]
Kd 0.00074Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
18
[SID103694306]
Kd 0.00074Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
19
[SID103694306]
Kd 0.00077Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
20
[SID103694306]
Kd 0.00077Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
21
[SID103694306]
Kd 0.00079Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
22
[SID103694306]
Kd 0.00079Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
23
[SID103694306]
Kd 0.00079Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
24
[SID103694306]
Kd 0.00079Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
25
[SID103694306]
Kd 0.00079Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
26
[SID103694306]
Kd 0.00079Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
27
[SID103694306]
Kd 0.00092Binding constant for LOK kinase domain [AID625030, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
View
28
[SID103694306]
Kd 0.00092Binding constant for LOK kinase domain [AID625030, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
View
29
[SID103694306]
Kd 0.00092Binding constant for LOK kinase domain [AID435677, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
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30
[SID103694306]
Kd 0.00092Binding constant for LOK kinase domain [AID435677, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
View
31
[SID103694306]
Kd 0.00093Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
32
[SID103694306]
Kd 0.00093Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
33
[SID103694306]
Kd 0.00094Binding constant for CDC2L5 kinase domain [AID624761, Type: Literature]Cyclin-dependent kinase 13 [gi:66774048]
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34
[SID103694306]
Kd 0.0014Binding constant for CDK8 kinase domain [AID435903, Type: Literature]Cyclin-dependent kinase 8 [gi:1345718]
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35
[SID103694306]
Kd 0.0014Binding constant for CDK8 kinase domain [AID435903, Type: Literature]Cyclin-dependent kinase 8 [gi:1345718]
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36
[SID103694306]
Kd 0.0014Binding constant for CDK8 kinase domain [AID624829, Type: Literature]Cyclin-dependent kinase 8 [gi:1345718]
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37
[SID103694306]
Kd 0.0014Binding constant for CDK8 kinase domain [AID624829, Type: Literature]Cyclin-dependent kinase 8 [gi:1345718]
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38
[SID103694306]
Kd 0.0015Binding constant for CDK11 kinase domain [AID435522, Type: Literature]Cyclin-dependent kinase 19 [gi:60391917]
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39
[SID103694306]
Kd 0.0015Binding constant for CDK11 kinase domain [AID435522, Type: Literature]Cyclin-dependent kinase 19 [gi:60391917]
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40
[SID103694306]
Kd 0.0015Binding constant for CDK11 kinase domain [AID625094, Type: Literature]Cyclin-dependent kinase 19 [gi:60391917]
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41
[SID103694306]
Kd 0.0015Binding constant for CDK11 kinase domain [AID625094, Type: Literature]Cyclin-dependent kinase 19 [gi:60391917]
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42
[SID103694306]
Kd 0.0015Binding constant for TAK1 kinase domain [AID624724, Type: Literature]Mitogen-activated protein kinase kinase kinase 7 [gi:12643557]
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43
[SID103694306]
Kd 0.0015Binding constant for TAK1 kinase domain [AID624724, Type: Literature]Mitogen-activated protein kinase kinase kinase 7 [gi:12643557]
View
44
[SID103694306]
Kd 0.0019Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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45
[SID103694306]
Kd 0.0019Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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46
[SID103694306]
Kd 0.0021Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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47
[SID103694306]
Kd 0.0021Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
48
[SID103694306]
Kd 0.0023Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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49
[SID103694306]
Kd 0.0023Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
50
[SID103694306]
Kd 0.0023Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View