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Toluene (CID 1140) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(534)
 
 
Inconclusive(25)
 
 
Unspecified(25)
 
 
Top Targets:
NR LBD PPAR(20)
 
 
 
NR LBD ER(18)
 
 
 
NR LBD AR(18)
 
 
 
NR LBD TR(14)
 
 
 
NR LBD GR(12)
 
 
BioAssay Types:
Confirmatory(437)
 
 
 
Literature(88)
 
 
 
 
Summary(39)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(394)
 
 
 
Kd(6)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 297    Data Row: 590   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179264]
IC50 0.00525Inhibition of acetylcholinesterase. [AID32248, Type: Literature]
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2
[SID103179264]
IC50 4.9IC50 against acetylcholinesterase; value ranges from 1-4900 nM. [AID32280, Type: Literature]
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3
[SID48414549]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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4
[SID48414549]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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5
[SID48414549]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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6
[SID48415083]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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7
[SID103179264]
Kd 71Binding affinity to Enterobacteria phage T4 lysozyme L99A/M102E double mutant expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry [AID728447, Type: Literature]
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8
[SID103179264]
Kd 102Binding affinity to Enterobacteria phage T4 lysozyme L99A mutant expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry [AID728449, Type: Literature]
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9
[SID103179264]
Kd 102Dissociation constant against T4 lysozyme mutant L99A [AID238119, Type: Literature]Lysozyme [gi:126605]
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10
[SID103179264]
Kd 156Dissociation constant against T4 lysozyme mutant L99A/M102Q [AID238124, Type: Literature]Lysozyme [gi:126605]
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11
[SID103179264]
Kd 156Binding affinity to Enterobacteria phage T4 lysozyme L99A/M102Q double mutant expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry [AID728448, Type: Literature]
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12
[SID103179264]
Kd 905Binding affinity to Enterobacteria phage T4 lysozyme L99A/M102H double mutant expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry [AID728450, Type: Literature]
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13
[SID103179264]
LC50 7.4131e+08Toxicity determined using Konemann's Industrial Pollutants Toxicity Test [AID162229, Type: Literature]
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14
[SID103179264]
Eye irritation potential accessed using Draize in vivo rabbit eye irritation test [AID167125, Type: Literature]
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15
[SID103179264]
Inhibition of Rana pipiens muscle activity. [AID168703, Type: Literature]
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16
[SID103179264]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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17
[SID103179264]
Binding affinity to beta cyclodextrin [AID346025, Type: Literature]
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18
[SID103179264]
Binding affinity to Enterobacteria phage T4 lysozyme L99A/M102H double mutant expressed in Escherichia coli BL21(DE3) assessed as change in melting temperature at 5 mM at pH 5.4 by circular dichroism analysis [AID728441, Type: Literature]
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19
[SID103179264]
Selectivity ratio of Kd for Enterobacteria phage T4 lysozyme L99A/M102H double mutant to Kd for Enterobacteria phage T4 lysozyme L99A/M102Q double mutant [AID728445, Type: Literature]
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20
[SID17389706]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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21
[SID103179264]
Aqueous solubility [AID19262, Type: Literature]
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22
[SID103179264]
Partition coefficient (logP) [AID24226, Type: Literature]
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23
[SID103179264]
logBB, log(C brain / C blood) [AID26047, Type: Literature]
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24
[SID103179264]
Toxicity determined using Microtox Test [AID159270, Type: Literature]
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25
[SID103179264]
In-vitro air to lung partition coefficients of the compound, logK(lung) (human/rat) [AID603950, Type: Literature]
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26
[SID103179264]
In-vitro air to blood partition coefficients of the compound, logK(blood) (human/rat) [AID603951, Type: Literature]
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27
[SID103179264]
In-vitro blood to lung partition coefficients of the compound, logP(lung) (human/rat) [AID603952, Type: Literature]
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28
[SID103179264]
Octanol-water partition coefficient, log P of the compound [AID603957, Type: Literature]
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29
[SID103179264]
Lipophilicity, log D of the compound in octanol-water at pH 7.4 by reverse-phase HPLC analysis [AID644414, Type: Literature]
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30
[SID17388690]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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31
[SID17388690]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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32
[SID17389706]
Potency 12.5893qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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33
[SID17388690]
Potency qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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34
[SID17388690]
Potency qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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35
[SID17388690]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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36
[SID17389706]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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37
[SID17388690]
Potency qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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38
[SID17389706]
Potency qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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39
[SID17389706]
Potency qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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40
[SID144204593]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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41
[SID144204593]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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42
[SID144208422]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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43
[SID144208422]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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44
[SID17388690]
Potency qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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45
[SID17388690]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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46
[SID17388690]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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47
[SID17388690]
Potency qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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48
[SID17388690]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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49
[SID17388690]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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50
[SID17389706]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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