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BioActivity Data for Compound Thymine (CID 1135)

BioActivity Outcomes:
Active(1)
 
 
Inactive(25)
 
 
Inconclusive(5)
 
 
Unspecified(7)
 
 
Top Targets:
NR LBD RXR li..(2)
 
 
 
BioAssay Types:
Literature(13)
 
 
 
 
Confirmatory(6)
 
 
 
Summary(3)
 
 
BioAssay Categories:
In vivo(10)
 
 
 
 
Biochemical(1)
 
 
Toxicity(5)
 
 
 
ADME(1)
 
 
Cell-based(10)
 
 
 
BioActivity Types:
Potency(9)
 
 
 
IC50(3)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 38    Data Row: 38   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID78806]
NCI In Vivo Anticancer Drug Screen. Data for tumor model Mammary Adenocarcinoma CD8F1 (subcutaneous) in CD8F1 [AID220, Type: other]
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2
[SID103263715]
IC50 100Cytotoxicity was determined in PBM cells, relative to RVT [AID155299, Type: Literature]
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3
[SID103263715]
IC50 100Cytotoxicity was determined in Vero cells, relative to RVT [AID217732, Type: Literature]
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4
[SID103263715]
IC50 100Cytotoxicity was determined in CEM cells, relative to RVT [AID47311, Type: Literature]
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5
[SID103263715]
Ki 347000Inhibitory activity against mouse liver thymidine phosphorylase at 0.15 mM thymidine substrate [AID211081, Type: Literature]
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6
[SID103263715]
Cytotoxicity against MDCK cells [AID501988, Type: Literature]
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7
[SID103263715]
Antiviral activity against Influenza A virus H5N1 Vietnam/1203/2004H infected in MDCK cells [AID501986, Type: Literature]
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8
[SID103263715]
Antiviral activity against Influenza B virus Florida/4/2006 infected in MDCK cells [AID501987, Type: Literature]
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9
[SID103263715]
Cytotoxicity against human KB cells at 30 uM [AID477229, Type: Literature]
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10
[SID251919935]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the RXR signaling pathway - cell viability counter screen [AID1159529, Type: confirmatory]
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11
[SID251919935]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the AP-1 signaling pathway [AID1159526, Type: confirmatory]
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12
[SID251919935]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the AP-1 signaling pathway - cell viability counter screen [AID1159525, Type: confirmatory]
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13
[SID251919935]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen [AID1159520, Type: confirmatory]
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14
[SID103263715]
Antitumor activity against mouse B16 cells allografted in C57Bl/6 mouse at 25 mg/kg/day, ip administered for 2 weeks relative to control [AID1149715, Type: Literature]
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15
[SID103263715]
Antitumor activity against mouse P388 cells allografted in DBA/2 mouse at 25 mg/kg/day, ip administered for 2 weeks relative to control [AID1149714, Type: Literature]
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16
[SID103263715]
Antitumor activity against rat Walker 256 cells allografted in Sprague-Dawley rat at 2.5 mg/kg/day, ip relative to control [AID1149713, Type: Literature]
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17
[SID251919935]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID1159521, Type: confirmatory]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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18
[SID251919935]
Antagonist Potency (uM) qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway: Summary [AID1159523, Type: summary]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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19
[SID251919935]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the AP-1 signaling pathway: Summary [AID1159528, Type: summary]v-jun sarcoma virus 17 oncogene homolog (avian) [Homo sapiens] [gi:119627033]
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20
[SID251919935]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the RXR signaling pathway: Summary [AID1159531, Type: summary]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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