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CHEMBL192518 (CID 11335874) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Unspecified(5)
 
 
Top Targets:
NR LBD PPAR(10)
 
 
 
BioAssay Types:
Literature(12)
 
 
 
BioActivity Types:
EC50(7)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 12    Data Row: 12   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103460087]
EC50 0.00027Effective concentration against murine PPARalpha in transactivation assay [AID240162, Type: Literature]
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2
[SID103460087]
EC50 0.5Effective concentration against human PPARalpha expressed in HepG2 cells [AID240267, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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3
[SID103460087]
EC50 0.5Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay [AID648525, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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4
[SID103460087]
EC50 0.50119Agonist activity at GAL4-fused PPARalpha (unknown origin) expressed in human HepG2 cells by transactivation assay [AID744325, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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5
[SID103460087]
EC50 0.89125Agonist activity at GAL4-fused PPARgamma (unknown origin) expressed in human HepG2 cells by transactivation assay [AID744324, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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6
[SID103460087]
EC50 0.9Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay [AID648526, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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7
[SID103460087]
EC50 0.9Effective concentration against human PPARgamma expressed in HepG2 cells [AID240268, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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8
[SID103460087]
Efficacy against human PPARgamma expressed in HepG2 cells relative to rosiglitazone [AID243396, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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9
[SID103460087]
Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay relative to Wy-14643 [AID648529, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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10
[SID103460087]
Efficacy against murine PPARalpha relative to Wy-14,643 [AID243394, Type: Literature]
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11
[SID103460087]
Efficacy against human PPARalpha expressed in HepG2 cells relative to Wy-14,643 [AID243395, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
12
[SID103460087]
Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay relative to pioglitazone [AID648530, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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