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A-674563 (CID 11314340) - Compound BioActivity Data
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BioActivity Outcomes:
Active(170)
 
 
Inactive(13)
 
 
Inconclusive(1)
 
 
Unspecified(329)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(43)
 
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
BioAssay Types:
Literature(498)
 
 
 
 
 
Confirmatory(15)
 
 
 
BioActivity Types:
Kd(442)
 
 
 
Ki(20)
 
 
 
Potency(16)
 
 
 
 
IC50(5)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 509    Data Row: 513   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103491101]
Kd 0.00051Binding constant for CLK2 kinase domain [AID624932, Type: Literature]Dual specificity protein kinase CLK2 [gi:1705919]
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2
[SID103491101]
Kd 0.00053Binding constant for CLK4 kinase domain [AID625125, Type: Literature]Dual specificity protein kinase CLK4 [gi:34922132]
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3
[SID103491101]
Kd 0.0014Binding constant for CLK1 kinase domain [AID624764, Type: Literature]Dual specificity protein kinase CLK1 [gi:206729857]
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4
[SID103491101]
Kd 0.0021Binding constant for DYRK1A kinase domain [AID624712, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1A [gi:3219996]
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5
[SID103491101]
Kd 0.0039Binding constant for DYRK1B kinase domain [AID624964, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1B [gi:9296963]
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6
[SID103491101]
Kd 0.0095Binding constant for PRKCH kinase domain [AID625049, Type: Literature]Protein kinase C eta type [gi:281185512]
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7
[SID103491101]
Ki 0.011Inhibition of Akt1 in presence of 10 uM ATP [AID266586, Type: Literature]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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8
[SID103491101]
Kd 0.011Binding constant for PRKCE kinase domain [AID625014, Type: Literature]Protein kinase C epsilon type [gi:400135]
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9
[SID103491101]
Kd 0.012Binding constant for PRKCQ kinase domain [AID625051, Type: Literature]Protein kinase C theta type [gi:20141582]
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10
[SID103491101]
Kd 0.013Binding constant for CIT kinase domain [AID625065, Type: Literature]Citron Rho-interacting kinase [gi:57015279]
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11
[SID103491101]
IC50 0.014Inhibition of human Akt1 [AID290872, Type: Literature]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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12
[SID103491101]
Ki 0.016Inhibition of PKA [AID266592, Type: Literature]cAMP-dependent protein kinase catalytic subunit gamma [gi:33860173]
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13
[SID103491101]
Ki 0.016Inhibition of PKA [AID266592, Type: Literature]cAMP-dependent protein kinase catalytic subunit alpha [gi:125205]
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14
[SID103491101]
Ki 0.016Inhibition of PKA [AID266592, Type: Literature]cAMP-dependent protein kinase catalytic subunit beta [gi:125210]
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15
[SID103491101]
Kd 0.019Binding constant for PRKG2 kinase domain [AID625053, Type: Literature]cGMP-dependent protein kinase 2 [gi:6226833]
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16
[SID103491101]
Kd 0.027Binding constant for PRKCD kinase domain [AID625048, Type: Literature]Protein kinase C delta type [gi:205371776]
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17
[SID103491101]
Kd 0.037Binding constant for ROCK1 kinase domain [AID625015, Type: Literature]Rho-associated protein kinase 1 [gi:47605999]
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18
[SID103491101]
Kd 0.043Binding constant for AAK1 kinase domain [AID625089, Type: Literature]AP2-associated protein kinase 1 [gi:300669613]
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19
[SID103491101]
Kd 0.043Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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20
[SID103491101]
Ki 0.046Inhibition of CDK2 [AID266596, Type: Literature]Cyclin-dependent kinase 2 [gi:116051]
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21
[SID103491101]
Kd 0.056Binding constant for PKAC-alpha kinase domain [AID624881, Type: Literature]cAMP-dependent protein kinase catalytic subunit alpha [gi:125205]
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22
[SID103491101]
Kd 0.063Binding constant for DYRK2 kinase domain [AID624918, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 2 [gi:148887370]
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23
[SID103491101]
Kd 0.07Binding constant for CDK7 kinase domain [AID624845, Type: Literature]Cyclin-dependent kinase 7 [gi:1705722]
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24
[SID103491101]
Kd 0.076Binding constant for AKT1 kinase domain [AID624994, Type: Literature]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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25
[SID103491101]
Kd 0.078Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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26
[SID103491101]
IC50 0.079Inhibition of ROCK1 [AID454997, Type: Literature]
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27
[SID103491101]
Kd 0.083Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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28
[SID103491101]
Kd 0.089Binding constant for ERK8 kinase domain [AID624715, Type: Literature]Mitogen-activated protein kinase 15 [gi:74760462]
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29
[SID103491101]
Kd 0.09Binding constant for PKAC-beta kinase domain [AID624882, Type: Literature]cAMP-dependent protein kinase catalytic subunit beta [gi:125210]
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30
[SID103491101]
Kd 0.092Binding constant for DMPK kinase domain [AID624950, Type: Literature]Myotonin-protein kinase [gi:363548519]
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31
[SID103491101]
Kd 0.095Binding constant for MRCKB kinase domain [AID625031, Type: Literature]Serine/threonine-protein kinase MRCK beta [gi:92090617]
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32
[SID103491101]
Kd 0.097Binding constant for PRKX kinase domain [AID624976, Type: Literature]cAMP-dependent protein kinase catalytic subunit PRKX [gi:1709648]
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33
[SID103491101]
Kd 0.1Binding constant for MINK kinase domain [AID624813, Type: Literature]Misshapen-like kinase 1 [gi:296437370]
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34
[SID103491101]
Kd 0.11Binding constant for HIPK3 kinase domain [AID625023, Type: Literature]Homeodomain-interacting protein kinase 3 [gi:61213741]
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35
[SID103491101]
Ki 0.11Inhibition of GSK3-beta [AID266598, Type: Literature]Glycogen synthase kinase-3 beta [gi:20455502]
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36
[SID103491101]
Kd 0.12Binding constant for BIKE kinase domain [AID625109, Type: Literature]BMP-2-inducible protein kinase [gi:34222653]
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37
[SID103491101]
Kd 0.12Binding constant for CSNK1E kinase domain [AID624847, Type: Literature]Casein kinase I isoform epsilon [gi:1346369]
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38
[SID103491101]
IC50 0.125Inhibition of full length AKT1 [AID454995, Type: Literature]
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39
[SID103491101]
Kd 0.14Binding constant for MAP4K4 kinase domain [AID624756, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 4 [gi:29427585]
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40
[SID103491101]
Kd 0.14Binding constant for TNIK kinase domain [AID625093, Type: Literature]TRAF2 and NCK-interacting protein kinase [gi:29840818]
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41
[SID103491101]
Kd 0.14Binding constant for PIM3 kinase domain [AID624802, Type: Literature]Serine/threonine-protein kinase pim-3 [gi:215274221]
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42
[SID103491101]
Kd 0.16Binding constant for CLK3 kinase domain [AID624931, Type: Literature]Dual specificity protein kinase CLK3 [gi:148887358]
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43
[SID137275991]
Potency 0.1677qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. [AID624479, Type: confirmatory]
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44
[SID103491101]
Kd 0.18Binding constant for RET(V804M) kinase domain [AID625124, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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45
[SID103491101]
Kd 0.18Binding constant for GAK kinase domain [AID625012, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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46
[SID103491101]
Kd 0.18Binding constant for AKT3 kinase domain [AID625019, Type: Literature]RAC-gamma serine/threonine-protein kinase [gi:12643943]
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47
[SID103491101]
Kd 0.18Binding constant for CDK9 kinase domain [AID624830, Type: Literature]Cyclin-dependent kinase 9 [gi:68067660]
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48
[SID103491101]
Kd 0.18Binding constant for PIM1 kinase domain [AID624878, Type: Literature]Serine/threonine-protein kinase pim-1 [gi:83305339]
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49
[SID103491101]
Kd 0.2Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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50
[SID103491101]
Kd 0.2Binding constant for CDKL5 kinase domain [AID624905, Type: Literature]Cyclin-dependent kinase-like 5 [gi:6175070]
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