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A-674563 (CID 11314340) - Compound BioActivity Data
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BioActivity Outcomes:
Active(170)
 
 
Inactive(16)
 
 
Inconclusive(2)
 
 
Unspecified(329)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(43)
 
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
BioAssay Types:
Literature(498)
 
 
 
 
 
Confirmatory(18)
 
 
 
 
BioActivity Types:
Kd(442)
 
 
 
Ki(20)
 
 
 
Potency(20)
 
 
 
 
IC50(5)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 513    Data Row: 517   Total Pages: 26   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103491101]
Kd 0.00051Binding constant for CLK2 kinase domain [AID624932, Type: Literature]Dual specificity protein kinase CLK2 [gi:1705919]
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2
[SID103491101]
Kd 0.00053Binding constant for CLK4 kinase domain [AID625125, Type: Literature]Dual specificity protein kinase CLK4 [gi:34922132]
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3
[SID103491101]
Kd 0.0014Binding constant for CLK1 kinase domain [AID624764, Type: Literature]Dual specificity protein kinase CLK1 [gi:206729857]
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4
[SID103491101]
Kd 0.0021Binding constant for DYRK1A kinase domain [AID624712, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1A [gi:3219996]
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5
[SID103491101]
Kd 0.0039Binding constant for DYRK1B kinase domain [AID624964, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1B [gi:9296963]
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6
[SID103491101]
Kd 0.0095Binding constant for PRKCH kinase domain [AID625049, Type: Literature]Protein kinase C eta type [gi:281185512]
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7
[SID103491101]
Ki 0.011Inhibition of Akt1 in presence of 10 uM ATP [AID266586, Type: Literature]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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8
[SID103491101]
Kd 0.011Binding constant for PRKCE kinase domain [AID625014, Type: Literature]Protein kinase C epsilon type [gi:400135]
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9
[SID103491101]
Kd 0.012Binding constant for PRKCQ kinase domain [AID625051, Type: Literature]Protein kinase C theta type [gi:20141582]
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10
[SID103491101]
Kd 0.013Binding constant for CIT kinase domain [AID625065, Type: Literature]Citron Rho-interacting kinase [gi:57015279]
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11
[SID103491101]
IC50 0.014Inhibition of human Akt1 [AID290872, Type: Literature]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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12
[SID103491101]
Ki 0.016Inhibition of PKA [AID266592, Type: Literature]cAMP-dependent protein kinase catalytic subunit gamma [gi:33860173]
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13
[SID103491101]
Ki 0.016Inhibition of PKA [AID266592, Type: Literature]cAMP-dependent protein kinase catalytic subunit alpha [gi:125205]
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14
[SID103491101]
Ki 0.016Inhibition of PKA [AID266592, Type: Literature]cAMP-dependent protein kinase catalytic subunit beta [gi:125210]
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15
[SID103491101]
Kd 0.019Binding constant for PRKG2 kinase domain [AID625053, Type: Literature]cGMP-dependent protein kinase 2 [gi:6226833]
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16
[SID103491101]
Kd 0.027Binding constant for PRKCD kinase domain [AID625048, Type: Literature]Protein kinase C delta type [gi:205371776]
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17
[SID103491101]
Kd 0.037Binding constant for ROCK1 kinase domain [AID625015, Type: Literature]Rho-associated protein kinase 1 [gi:47605999]
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18
[SID103491101]
Kd 0.043Binding constant for AAK1 kinase domain [AID625089, Type: Literature]AP2-associated protein kinase 1 [gi:300669613]
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19
[SID103491101]
Kd 0.043Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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20
[SID103491101]
Ki 0.046Inhibition of CDK2 [AID266596, Type: Literature]Cyclin-dependent kinase 2 [gi:116051]
View